全文获取类型
收费全文 | 544篇 |
免费 | 32篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 19篇 |
妇产科学 | 20篇 |
基础医学 | 55篇 |
口腔科学 | 54篇 |
临床医学 | 25篇 |
内科学 | 149篇 |
皮肤病学 | 3篇 |
神经病学 | 54篇 |
特种医学 | 3篇 |
外科学 | 53篇 |
综合类 | 1篇 |
预防医学 | 47篇 |
眼科学 | 9篇 |
药学 | 38篇 |
中国医学 | 7篇 |
肿瘤学 | 23篇 |
出版年
2023年 | 4篇 |
2022年 | 3篇 |
2021年 | 16篇 |
2020年 | 8篇 |
2019年 | 7篇 |
2018年 | 17篇 |
2017年 | 13篇 |
2016年 | 19篇 |
2015年 | 13篇 |
2014年 | 21篇 |
2013年 | 31篇 |
2012年 | 40篇 |
2011年 | 57篇 |
2010年 | 24篇 |
2009年 | 14篇 |
2008年 | 36篇 |
2007年 | 49篇 |
2006年 | 49篇 |
2005年 | 45篇 |
2004年 | 32篇 |
2003年 | 27篇 |
2002年 | 23篇 |
2001年 | 9篇 |
2000年 | 5篇 |
1999年 | 2篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1988年 | 1篇 |
1985年 | 1篇 |
1982年 | 1篇 |
1914年 | 1篇 |
1907年 | 1篇 |
排序方式: 共有577条查询结果,搜索用时 15 毫秒
91.
Torres MC das Chagas L Pinto F Braz-Filho R Silveira ER Pessoa OD Jorge RJ Ximenes RM Monteiro HS Monteiro Evangelista JS Diz-Filho EB Toyama MH 《Journal of natural products》2011,74(10):2168-2173
Three new solanidane alkaloids bearing a 22,23-epoxy ring (1-3) and four known compounds were isolated from leaves of Solanum campaniforme. The structures were determined using spectroscopic techniques, including 1D and 2D NMR, and HRESIMS experiments. The antiophidic activity of the alkaloids was tested against Bothrops pauloensis venom. Compounds 1-3 completely inhibited myotoxicity without inhibiting phospholipase A2 activity of the venom, while hemorrhage and skin necrosis were significantly reduced in the presence of alkaloids 1 and 2. 相似文献
92.
Hajjar LA Nakamura RE de Almeida JP Fukushima JT Hoff PM Vincent JL Auler JO Galas FR 《Clinics (S?o Paulo, Brazil)》2011,66(12):2037-2042
OBJECTIVE:
Cancer patients frequently require admission to intensive care unit. However, there are a few data regarding predictive factors for mortality in this group of patients. The aim of this study was to evaluate whether arterial lactate or standard base deficit on admission and after 24 hours can predict mortality for patients with cancer.METHODS:
We evaluated 1,129 patients with severe sepsis, septic shock, or postoperative after high-risk surgery. Lactate and standard base deficit collected at admission and after 24 hours were compared between survivors and non-survivors. We evaluated whether these perfusion markers are independent predictors of mortality.RESULTS:
There were 854 hospital survivors (76.5%). 24 h lactate >1.9 mmol/L and standard base deficit < -2.3 were independent predictors of intensive care unit mortality. 24 h lactate >1.9 mmol/L and 24 h standard base deficit < -2.3 mmol/Lwere independent predictors of hospital death.CONCLUSION:
Our findings suggest that lactate and standard base deficit measurement should be included in the routine assessment of patients with cancer admitted to the intensive care unit with sepsis, septic shock or after high-risk surgery. These markers may be useful in the adequate allocation of resources in this population. 相似文献93.
Tobias Engel Ayer Botrel Otávio Augusto C. Clark Luciana Clark Luciano Paladini Enéas Faleiros Bruna Pegoretti 《Supportive care in cancer》2011,19(6):823-832
Objective
The objective of this work is to perform a systematic review and meta-analysis of all randomized controlled trials comparing a single intravenous dose of palonosetron (PAL) 0.25 mg with other 5-HT3R in patients receiving moderately or highly emetogenic (MoHE) chemotherapy. 相似文献94.
Centeno RS Yacubian EM Caboclo LO Júnior HC Cavalheiro S 《Arquivos de neuro-psiquiatria》2011,69(4):693-698
The advent of modern image-guided surgery has revolutionized depth electrode implantation techniques. Stereoelectroencephalography (SEEG), introduced by Talairach in the 1950s, is an invasive method for three-dimensional analysis on the epileptogenic zone based on the technique of intracranial implantation of depth electrodes. The aim of this article is to discuss the principles of SEEG and their evolution from the Talairach era to the image-guided surgery of today, along with future prospects. Although the general principles of SEEG have remained intact over the years, the implantation of depth electrodes, i.e. the surgical technique that enables this method, has undergone tremendous evolution over the last three decades, due the advent of modern imaging techniques, computer systems and new stereotactic techniques. The use of robotic systems, the constant evolution of imaging and computing techniques and the use of depth electrodes together with microdialysis probes will open up enormous prospects for applying depth electrodes and SEEG both for investigative use and for therapeutic use. Brain stimulation of deep targets and the construction of "smart" electrodes may, in the near future, increase the need to use this method. 相似文献
95.
Varella PP Santiago JF Carrete H Higa EM Yacubian EM Centeno RS Caboclo LO Castro Neto EF Canzian M Amado D Cavalheiro EA Naffah-Mazzacoratti Mda G 《Arquivos de neuro-psiquiatria》2011,69(1):91-99
We investigated a relationship between the FLAIR signal found in mesial temporal sclerosis (MTS) and inflammation. Twenty nine patients were selected through clinical and MRI analysis and submitted to cortico-amygdalo-hippocampectomy to seizure control. Glutamate, TNFα, IL1, nitric oxide (NO) levels and immunostaining against IL1β and CD45 was performed. Control tissues (n=10) were obtained after autopsy of patients without neurological disorders. The glutamate was decreased in the temporal lobe epilepsy (TLE) -MTS group (p<0.001), suggesting increased release of this neurotransmitter. The IL1β and TNFα were increased in the hippocampus (p<0.05) demonstrating an active inflammatory process. A positive linear correlation between FLAIR signal and NO and IL1β levels and a negative linear correlation between FLAIR signal and glutamate concentration was found. Lymphocytes infiltrates were present in hippocampi of TLE patients. These data showed an association between hippocampal signal alteration and increased inflammatory markers in TLE-MTS. 相似文献
96.
Ferrari TP Hamad AP Caboclo LO Centeno RS Zaninotto AL Scattolin M Carrete Junior H Lancellotti CL Yacubian EM 《Epileptic Disord》2011,13(3):321-325
A five-and-a-half-year-old girl started experiencing progressive left hemiparesis at age two and a half years. At age five years and four months she started presenting clusters of asymmetric periodic epileptic spasms with no hypsarrhythmia. The ictal EEG showed periodic, constant and stereotyped complexes. Serial brain imaging revealed progressive atrophy of the right hemisphere with increased T2 signal on MRI. She underwent a right hemispherotomy, and histological examination showed signs of inflammation and features of focal cortical dysplasia (FCD). She has been seizure-free for 16 months. This case is unique in the following aspects: the presence of typical Rasmussen encephalitis features of progressive unilateral brain involvement without seizures, a delay of almost three years prior to seizure onset; an atypical seizure type presentation with periodic epileptic spasms and the presence of FCD associated with inflammatory changes. [Published with video sequences]. 相似文献
97.
de Marcos Ortega L Barchino Plata R Jiménez Rodríguez ML Hilera González JR Martínez Herráiz JJ Gutiérrez de Mesa JA Gutiérrez Martínez JM Otón Tortosa S 《Computers, informatics, nursing : CIN》2011,29(5):311-317
Modern handheld devices and wireless communications foster new kinds of communication and interaction that can define new approaches to teaching and learning. Mobile learning (m-learning) seeks to use them extensively, exactly in the same way in which e-learning uses personal computers and wired communication technologies. In this new mobile environment, new applications and educational models need to be created and tested to confirm (or reject) their validity and usefulness. In this article, we present a mobile tool aimed at self-assessment, which allows students to test their knowledge at any place and at any time. The degree to which the students' achievement improved is also evaluated, and a survey on the students' opinion of the new tool was also conducted. An experimental group of 20- to 21-year-old nursing students was chosen to test the tool. Results show that this kind of tool improves students' achievement and does not make necessary to introduce substantial changes in current teaching activities and methodology. 相似文献
98.
Ribeiro AL Rocha MO Terranova P Cesarano M Nunes MD Lombardi F 《Journal of cardiovascular electrophysiology》2011,22(7):799-805
T‐Wave Amplitude Variability in Chagas Disease. Introduction: Measurement of beat‐to‐beat T‐wave amplitude variability (TWV) has been described as a promising new technique for the stratification of arrhythmic risk in postmyocardial infarction and dilated cardiomyopathy patients. Chagas disease (ChD) can lead to a potentially lethal cardiopathy that can present with ventricular arrhythmias, heart blocks, heart failure, and sudden death. The aim of the study was to evaluate the prognostic value of TWV in ChD patients in addition to traditional prognostic predictors. Methods and Results: The study enrolled 113 ambulatory ChD patients (62 men; age: 42 ± 9 years) in sinus rhythm and without other systemic diseases, evaluated by a standard clinical protocol. We computed TWV in 10‐minute ECG recordings obtained in controlled resting conditions. TWV was defined as the median values among 8 consecutive 50‐ms T‐wave segments and dichotomized as either ≤ or > 30 μV2. The association of TWV and death was evaluated by Cox proportional‐hazards analysis, considering other established predictors. During mean follow‐up time of 106 ± 28 months, 14 patients died. A value of median TWV > 30 μV2 predicts increased risk of death in a multivariate analysis (HR = 5.76, 95% CI 1.31–25.23, P = 0.014), in addition to depressed left ventricular function, presence of nonsustained ventricular tachycardia and QRS duration >133 ms. Conclusion: Repolarization variability, evaluated by TWV, is independently related to the risk of death in ChD. This noninvasive methodology could facilitate the identification of patients who may benefit from more aggressive therapeutic strategies. (J Cardiovasc Electrophysiol, Vol. 22, pp. 799‐805, July 2011) 相似文献
99.
Andréu JL Otón T Silva-Fernández L Sanz J 《Best Practice & Research: Clinical Rheumatology》2011,25(1):31-42
Some occupational factors have been implicated in the development of disorders manifested as hand pain. The associations seem to be well documented in processes such as hand-arm vibration syndrome (HAVS) or writer's cramp. There are contradictory data in the literature about the relationships of trigger finger, De Quervain's tenosynovitis (DQT) and tenosynovitis of the wrist with occupational factors. In this article, we review current knowledge about clinical manifestations, case definition, implicated occupational factors, diagnosis and treatment of the most relevant hand pain disorders that have been associated with occupational factors, excluding carpal tunnel syndrome (CTS). 相似文献
100.
No effective treatment has been documented for the glandular primary Sj?gren syndrome (PSS) despite the development of oral and biologic agents that have significant activity against other autoimmune disorders. Some disease-modifying agents have been empirically evaluated for the treatment of PSS. Targeting B cells also seems very promising in SSP because of the B-cell hyperactivity recognized in this desease. This article reviews existing data on the use of disease-modifying therapy for glandular of SSP. To date, published studies and trials of oral DMARDs for the treatment of SSP have shown disappointing results. B-cell modulation is clearly a promising therapy for PSS. Many challenges in trial design and execution are evident from the studies reviewed. 相似文献