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肺移植后肺感染的发生率比其它器官移植后明显增高,这提示移植肺的免疫反应可能受损。为了研究肺淋巴引流中断对抗体反应的影响,我们用肺门剥脱鼠作为模型,设计了3个实验:(1)用着色淋巴造影术目视检查肺门淋巴管的再生;(2)在支气管内滴注碳粒子后观察粒子从肺到肺引流淋巴结的运输;(3)用羊红细胞使肺免疫后测定抗体反应。结果显示肺门淋巴管被肺门剥脱术所中断,在术后7天开始再生;在术后第1周粒子运输到肺引流淋巴结受阻,此后逐渐恢复正常;在肺门剥脱后7天和10天免疫的鼠血清抗体反应缺如或低下,其后1月内恢复。由此得出结论,只要抗原不能经淋巴管从肺运送到肺引流淋巴结,肺门剥脱肺内的抗原抗体反应就受到损害。该发现可部分地解释为什么在肺移植后最初几周内经常发生肺感染。 相似文献
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Walter JB; Brander C; Mammen M; Garboczi DN; Kalams SA; Whitesides GM; Walker BD; Eisen HN 《International immunology》1997,9(3):451-459
HLA-A2 heavy chain and beta 2-microglobulin were expressed in Escherichia
coli, and refolded in the presence of peptides derived from HIV-1 RT and
gag proteins. When recombinant HLA-A2 molecules were attached to cells
lacking HLA-A2, the cells became susceptible to lysis by HLA-A2-restricted
cytotoxic T lymphocyte (CTL) clones specific for peptides derived from RT
and gag proteins. Limiting dilution analyses of peripheral blood
mononuclear cells from HIV-1-infected individuals showed that the
recombinant HLA-A2 peptide complexes covalently immobilized on microspheres
stimulated the development of HLA-A2 peptide-specific CTL. Preformed
HLA-peptide complexes may provide an alternative to immunization procedures
that depend upon intracellular processing of antigen to elicit T cell
responses.
相似文献
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Doppman JL; Dedrick RL; Shook DR; Lutz RJ; Goldstein SR; Blacklock JB; Boretos JW; Paul RH; Austin HA d; Bowman RL 《Radiology》1986,159(2):477-483
Techniques have been developed for isolated perfusion of chemotherapeutic agents in patients with glioblastoma. Three catheters that facilitate crossing the carotid siphon have been developed; two are based on an everting or toposcopic principle, and one uses microjets for deflectability and improved mixing. Blood from the ipsilateral jugular vein is aspirated at high volumes (300 ml/min) for extracorporeal circulation through an adsorption column (for recovery of carmustine) or dialysers (for recovery of cisplatin). Preliminary experience in 10 patients suggests that high doses of chemotherapeutic agent can be administered using these catheters, with reduced retinal and systemic toxicity. 相似文献
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LUCIANO A FAVORITO CARLOS AB KLOJDA FRANCISCO JB SAMPAIO 《International journal of urology》2004,11(12):1110-1113
BACKGROUND: The aim of the present study is to make a comparative study in human fetuses and in patients with cryptorchidism, analyzing the incidence of a number anomalies of the testes for both populations. METHODS: We studied 326 testes from 163 human fetuses ranging in age from 10 to 35 weeks postconception (WPC) and 133 testes from 101 cryptorchid patients aged from 1 to 15 years old (mean, 6.4 years). The Fisher's exact test was used for comparison. RESULTS: Among 326 fetal testes, 224 (68.7%) were abdominal, 45 (13.8%) were inguinal and 55 (16.8%) were scrotal. In one fetus at 23 WPC, both testes (0.6%) were absent. Of the 133 cryptorchid testes, 17 (12.78%) were abdominal, 92 (69.1%) were inguinal and 24 (18%) were high scrotal. Of the 17 abdominal testes, three (17.6%) were atrophic and two were vanished (11.7%). Of the 92 inguinal testes, one (1.08%) was vanished. Twenty-eight (21%) of the cryptorchid testes were impalpable and among these, 17 were located in the abdomen (60.7%) and 11 (38.2%) in the inguinal region (internal ring). CONCLUSIONS: Testicular agenesis is a very rare anomaly, both in fetuses and patients with cryptorchidism. 相似文献
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鉴定γB-晶体蛋白非酶糖基化位点。方法用离子交换HPLC纯化小牛晶状体γB-晶体蛋白,与果糖保温后用糜蛋白酶水解。糖基化的肽用Affi-Gel601柱层析纯化,并用RP-HPLC分离各肽。 相似文献