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981.
Nobuo Kanazawa Atsushi Ono Gaku Nitou Ei Ueno Masachika Fujiwara Hiroshi Kamma Naotaka Izumiya Katashi Fukao 《Surgery today》1999,29(9):939-944
A 70-year-old woman presented with a huge tumor in her left breast, which had rapidly increased in size causing cutaneous
erosion. She underwent a simple mastectomy, at which time the tumor was found to be an encapsulated multilocular cystic lesion
containing dark fluid. Histological examination disclosed the characteristic features of malignant hemangiopericytoma, including
the perivascular lamellar growth of atypical mesenchymal cells with vimentin-positive cytoplasm. Multiple irregular vascular
luminal formation was also conspicuous. The characteristics of this lesion are discussed together with a review of the previous
literature on this unusual neoplasm. 相似文献
982.
Shinya Uchino Shiro Noguchi Mari Sato Mitsuo Adachi Hiroyuki Yamashita Shin Watanabe Tsukasa Murakami Masakatsu Toda Nobuo Murakami Hiroto Yamashita 《Surgery today》1999,29(9):862-867
DNA extracted from the peripheral blood leukocytes of 36 members of five families with multiple endocrine neoplasia (MEN)
type 2A was analyzed for mutations of exons 10, 11, 13, 14, and 16 of theRET proto-oncogene by nonisotopic polymerase chain reaction-single-strand conformation polymorphism analysis and automated DNA
sequencing. Germline mutations were found in all 9 of the affected individuals and in 6 of the 27 individuals of unknown status.
A 70-year-old man who had been completely asymptomatic before genetic diagnosis underwent left adrenalectomy and total thyroidectomy,
and was found to have pheochromocytoma and multifocal micromedullary thyroid carcinoma (MTC), A 32-year-old man and a 15-year-old
boy, with elevated calcitonin levels detected by the C-cell-stimulation test, but no evident thyroid tumor, underwent total
thyroidectomy. Histopathological diagnosis revealed multiple micro MTCs. A 7-year-old girl without evidence of a thyroid tumor
or an elevated calcitonin level is being followed up. The remaining two subjects with an evident thyroid tumor and elevated
calcitonin levels refused surgery. These results suggest that genetic screening for MEN type 2 afflicted family members can
facilitate the presymptomatic detection of gene carriers. Thus, we must carefully evaluate whether immediate prophylactic
total thyroidectomy is indicated for gene carriers of MEN 2A without an evident thyroid tumor or elevated calcitonin levels. 相似文献
983.
Saya Tamura Takuma Hayashi Tomoyuki Ichimura Nobuo Yaegashi Kaoru Abiko Ikuo Konishi 《Current oncology (Toronto, Ont.)》2022,29(4):2350
Background/Aim: Patients with uterine sarcoma comprise 2–5% of all patients with uterine malignancies; however, the morbidity of uterine sarcoma is low compared with that of other gynecological cancers. For many cases, malignant uterine tumors are diagnosed during follow-up of benign uterine leiomyoma. Of the uterine sarcomas, rhabdomyosarcoma is considered a mixed tumor containing components of epithelial cells and mesenchymal cells. Therefore, the onset of primary uterine rhabdomyosarcoma during follow-up of uterine leiomyoma is extremely rare. Rhabdomyosarcoma is a relatively common malignant tumor in children, but rhabdomyosarcoma in adults is extremely rare, accounting for approximately 3% of all patients with soft tissue sarcoma. Rhabdomyosarcoma in children is highly sensitive to chemotherapy and radiation therapy; however, the response to chemotherapy and radiation therapy in adult rhabdomyosarcoma is low and survival in adult rhabdomyosarcoma with metastatic lesions to other organs is approximately 14 months. We experienced a case of pleomorphic rhabdomyosarcoma during the follow-up of a uterine leiomyoma. Materials and Methods: We examined the oncological properties of uterine rhabdomyosarcoma in adults using molecular pathological techniques on tissue excised from patients with uterine leiomyoma. Result: A differential diagnosis was made for this case by molecular pathology, which included candidate biomarkers for uterine smooth muscle tumors. The oncological nature of uterine rhabdomyosarcoma was found to be similar to the oncological properties of uterine leiomyosarcoma. However, in uterine rhabdomyosarcoma, LMP2/β1i-positive cells were clearly observed. Conclusion: It is expected that establishing a diagnostic and treatment method targeting characteristics of mesenchymal tumor cells will lead to the treatment of malignant tumors with a low risk of recurrence and metastasis. 相似文献
984.
Hiroyuki Sugiura Nobuo Sezaki Tatsunori Ishikawa Taiga Kuroi Sachiyo Okamoto Naho Nomura Taro Masunari Yukio Nakasako Toru Kiguchi Mitsune Tanimoto 《Clinical Case Reports》2022,10(4)
Venetoclax is a promising new drug for relapsed or refractory chronic lymphocytic leukemia (CLL). However, venetoclax use had not been reported in severe chronic kidney disease (CKD) patients. We report the first case of relapsed CLL in a severe CKD patient that was successfully treated with venetoclax. 相似文献
985.
Kaji K Yoshida S Nagata N Yamashita T Mizukoshi E Honda M Kojima Y Kaneko S 《Journal of gastroenterology》2004,39(9):873-878
Background In this study, we examined the effect of EH0202, a mixture of four herbal extracts that are known to induce interferons, on hepatitis C virus (HCV)-RNA levels in patients with chronic hepatitis C.Methods This was an open-label uncontrolled study. The study subjects ingested food containing EH0202 daily for 3 months, which was equivalent to 1g of desiccated herbs daily. Clinical symptoms, hematology and biochemical examinations, urine, and HCV-RNA levels were examined before, during (1 month), and after the EH0202 treatment (3 months).Results Among the 35 patients who successfully completed the study, there were improvements in malaise (seen in 6 patients before and in 2 after EH0202 treatment), bloating sensation in the abdomen (seen in 2 before and in none after treatment), and nausea and vomiting (seen in 2 before and in 1 after treatment). There were no changes in hematology or biochemical examination parameters. There was a statistically significant decrease in HCV-RNA levels in patients with high viral titers after 3 months of EH0202 administration. No serious adverse events were observed with the EH0202 treatment.Conclusions These findings suggest that EH0202 may be safe and useful in the treatment of patients with chronic hepatitis C. Further studies are, however, needed to obtain a definitive conclusion. 相似文献
986.
Ulinastatin for pancreatitis after endoscopic retrograde cholangiopancreatography: a randomized, controlled trial. 总被引:5,自引:0,他引:5
Takeshi Tsujino Yutaka Komatsu Hiroyuki Isayama Kenji Hirano Naoki Sasahira Natsuyo Yamamoto Nobuo Toda Yukiko Ito Yousuke Nakai Minoru Tada Masayuki Matsumura Haruhiko Yoshida Takao Kawabe Yasushi Shiratori Masao Omata 《Clinical gastroenterology and hepatology》2005,3(4):376-383
BACKGROUND & AIMS: Pancreatitis remains the major complication of endoscopic retrograde cholangiopancreatography (ERCP), and hyperenzymemia after ERCP is common. Because ulinastatin, a protease inhibitor, has proved effective in the treatment of acute pancreatitis, the aim of this study was to assess the efficacy of ulinastatin for the prevention of post-ERCP pancreatitis and hyperenzymemia. METHODS: In a multicenter, randomized, double-blind, placebo-controlled trial, patients undergoing a first ERCP were randomized to receive ulinastatin (150,000 U) or placebo by intravenous infusion for 10 minutes starting immediately before ERCP. All patients were hospitalized at least 24 hours after ERCP for evaluation of clinical symptoms. Serum pancreatic enzyme levels were measured before and at 4 and 18 hours after ERCP. The primary end point was the incidence of post-ERCP pancreatitis and the secondary objective was the occurrence of hyperenzymemia. RESULTS: A total of 406 patients were enrolled (204 in the ulinastatin group and 202 in the placebo group). There were no differences between the 2 groups regarding baseline characteristics, details of fluoroscopic findings, or endoscopic procedure. The incidence of hyperenzymemia was significantly lower in the ulinastatin group than in the placebo group (amylase, P = .011; lipase, P = .008). Six patients in the ulinastatin group and 15 patients in the placebo group developed pancreatitis (2.9% vs. 7.4%, P = .041). There was no case of severe pancreatitis in either group. Patients who received ulinastatin did not present any side effects related to the medication. CONCLUSIONS: Prophylactic short-term administration of ulinastatin decreases the incidence of pancreatitis and hyperenzymemia after ERCP. 相似文献
987.
Relationship between airborne Cry j 1 and the onset time of the symptoms of Japanese cedar pollinosis patients. 总被引:1,自引:0,他引:1
Yuichi Takahashi Masaaki Aoyama Masanori Yoshitake Etsuko Abe Nobuo Ohta Masahiro Sakaguchi 《Allergology international》2007,56(3):277-283
BACKGROUND: Some patients with Japanese cedar (JC) pollinosis already show pollinosis symptoms before the first day of the pollen season as determined by microscopic pollen counts. METHODS: Airborne pollen allergen (Cry j 1) levels were measured by electron spin resonance radical immunoassay, a highly-sensitive method for Cry j 1 with a sensitivity 10-100-fold higher than conventional enzyme-linked immunosorbent assay. The symptom data from patients with JC pollinosis were collected from a mobile phone site, "pollen check sheet", and the onset times of the patients' symptoms were analyzed. RESULTS: The relationship between airborne Cry j 1 levels and the onset time of pollinosis symptoms was investigated. The symptoms of some patients began at the time airborne Cry j 1 levels fluctuated at 1 to 3 pg/m3 and symptom scores increased at the time of sudden increase in Cry j 1 levels. About 40% of patients began to show symptoms until the first day of the pollen season and the time nearly corresponds to the time of sudden increase in Cry j 1 levels. CONCLUSIONS: Pollinosis symptoms of some patients began at the time airborne Cry j 1 levels fluctuated at 1 to 3 pg/m3 and symptom scores increased at the time of sudden increase in Cry j 1 levels. The latter time nearly corresponds to the first day of the pollen season. 相似文献
988.
Hiroyuki Isayama Takao Kawabe Yousuke Nakai Takeshi Tsujino Naoki Sasahira Natsuyo Yamamoto Toshihiko Arizumi Osamu Togawa Saburou Matsubara Yukiko Ito Takashi Sasaki Kenji Hirano Nobuo Toda Yutaka Komatsu Minoru Tada Haruhiko Yoshida Masao Omata 《Clinical gastroenterology and hepatology》2006,4(9):1148-1153
BACKGROUND & AIMS: Cholecystitis after metallic stent (MS) placement is an issue requiring attention. From our experience, cholecystitis seemed to occur mainly in patients with tumor involvement to the cystic duct orifice. The aim of the present study was to identify risk factors for cholecystitis in patients treated with covered or uncovered MS. METHODS: We analyzed 246 patients who received MS placement (covered MS in 171 and uncovered in 75) between August 1997 and May 2005 for the treatment of unresectable distal malignant biliary obstruction. Causative diseases were as follows: pancreatic cancer in 162, papillary cancer in 10, bile duct cancer in 41, and metastatic nodes in 33 patients. Tumor involvement to orifice of the cystic duct (OCD) was diagnosed based on cholangiography and intraductal ultrasonography. RESULTS: Cholecystitis after MS placement was found in 13 patients (5.3%). There was no significant difference in the incidence of cholecystitis between covered (5.8%) and uncovered (4.0%) MS. By univariate analysis, tumor involvement of the OCD, MS placed above the papilla, and stricture located at midportion were associated significantly with cholecystitis. By multivariate analysis, only tumor involvement of the OCD was a risk factor, with an odds ratio of 47.206 (95% confidence interval, 5.84-381.60). CONCLUSIONS: Cholecystitis after MS placement is associated with tumor involvement to the orifice of the cystic duct, regardless of the type of stent. 相似文献
989.
Sugita J Tanaka J Kurosawa M Fukuhara T Hashino S Torimoto E Koizumi K Masauji N Nishimura S Koda K Imamura M Kasai M;Hokkaido Hematology Study Group 《European journal of haematology》2008,80(2):160-163
In this study, we retrospectively analyzed 213 Japanese patients with chronic myeloid leukemia (CML) treated with imatinib mesylate. In 150 evaluable patients, mean daily doses were 400 mg or more in 42 patients, 300–400 mg in 42 patients, 200–300 mg in 44 patients and <200 mg in 22 patients. Complete hematologic response was observed in all the 84 patients treated with mean daily doses of 300 mg or more and complete cytogenetic response was achieved in 94.8% of those patients. In comparison with the effects of 300 mg or more, mean daily doses of 200–300 mg led to less complete cytogenetic response (78.6% vs. 94.8%, P < 0.01), shorter complete cytogenetic remission duration (81.3% vs. 95.6% at 24 months, P = 0.01), and lower overall survival (90.0% vs. 98.8% at 36 months, P = 0.03). This study suggests that the mean daily doses of 300 mg (roughly equivalent to 100,000 mg/yr) or more may improve overall survival and that mean daily doses of imatinib during the first year may be one of the prognostic factors for CML in Japan. 相似文献