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971.
Nobuo Adachi Mitsuo Ochi Yuji Uchio Junji Iwasa Masakazu Ishikawa Rikuo Shinomiya 《Knee surgery, sports traumatology, arthroscopy》2007,15(1):2-8
A total of 29 patients who had undergone posterior cruciate ligament (PCL) reconstruction using multi-stranded hamstring tendons
were prospectively followed-up for joint stability and proprioceptive function at a minimum of 24 months after surgery. We
measured temporal changes of the posterior laxity by stress radiography and the KT-2000 arthrometer, and we also measured
joint position sense for an average of 42 months (range 24–78 months). In terms of results, improvement of joint stability
was observed postoperatively and maintained over 2 years after PCL reconstruction, although posterior stability in the reconstructed
knee was not identical to the contralateral normal knee. Although joint position sense worsened just after reconstruction,
it gradually recovered from 18 months after surgery. However, proprioceptive function after PCL reconstruction did not recover
to the same level as in the contralateral normal knee even over 24 months after surgery. 相似文献
972.
Hiroaki Naritomi Toshiro Fujita Sadayoshi Ito Toshio Ogihara Kazuyuki Shimada Kazuaki Shimamoto Heizo Tanaka Nobuo Yoshiike 《Hypertension research》2007,30(9):807-814
The Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) study is a nationwide, prospective, multicenter observational study that was designed to enroll hypertensive Japanese patients (>30,000 subjects). The patients in this study received treatment with open-label losartan, an angiotensin II receptor antagonist, for a maximum of 5 years. This report summarizes the study protocol and the baseline characteristics of the patients. Between June 2000 and May 2002, patients were screened in all 47 prefectures around Japan. Among the 31,515 patients screened, 31,048 patients were enrolled in this study and treated with losartan at a daily dose of 25-50 mg. These patients were 62.4 +/- 12.1 years old (mean +/- SD) and the mean clinic systolic/diastolic blood pressure (BP) values were 165.3 +/- 17.3/94.3 +/- 11.7 mmHg (mean +/- SD). The complications of hyperlipidemia, diabetes mellitus, cardiovascular disease, and cerebrovascular disease were also present in 38.5%, 13.1%, 8.0%, and 4.4% of patients, respectively. Regarding the World Health Organization classification, grade 2 hypertension was most frequent in this patient cohort. Nearly 10,000 patients agreed to perform home BP monitoring and report details regarding their lifestyles at baseline. Among the patients, 4.2% had white coat hypertension at the baseline. The J-HEALTH study is expected to provide valuable information about the significance of clinic and home BP control and home BP monitoring for the management of hypertension in Japanese patients. 相似文献
973.
974.
975.
Hiroshi Yoshimura Shigeto Morimoto Masashi Okuro Natsuki Segami Nobuo Kato 《The journal of physiological sciences : JPS》2010,60(5):383-388
In order to evaluate the stage of dementia, we focused attention on EEG rhythms and Hasegawa-dementia-rating scale (HDS-R).
Frontal EEGs were recorded from dementia patients and normal controls during music and photo-image stimulations, and frequency
analysis was performed. In the controls, profiles of rhythm pattern during music stimulation seemed to be markedly different
from those during photo-image stimulation. In contrast, in dementia patients, it was difficult to find those differences.
Interestingly, as HDS-R decreases, the variability of rhythm patterns also decreases. These results suggest that a decrease
in cognitive function might be related to a decrease in the ability to generate various cortical rhythm patterns. 相似文献
976.
Koji Okudela Tetsukan Woo Hideaki Mitsui Takuya Yazawa Hiroaki Shimoyamada Michihiko Tajiri Nobuo Ogawa Munetaka Masuda Hitoshi Kitamura 《International journal of clinical and experimental pathology》2010,3(4):348-366
We have established a concise sub-typing system suitable for predicting the postoperative outcome in cases of stage I lung adenocarcinoma (ADC), using morphometric profiling. The association between postoperative disease recurrence and a variety of morphological features including histological architecture, cell type, cytoplasmic color/internal structure, nuclear shape/size, chromatin pattern, and nucleoli count/remarkableness, was analyzed. Histological architecture had the most prognostic value and could be subdivided into low-grade (bronchioloalveolar, papillary and tubular: “tubular” in this paper is defined as a tubular or glandular structure lined with single-layered neoplastic cells) and high-grade (acinar and solid: “acinar” is defined as a tubular or glandular structure lined with poly-layered neoplastic cells or as a fused glandular structure such as the cribriform pattern) components. The subgroups separated based on a cut-off value, 71.5% of the high-grade component comprised by a tumor, which was calculated according to a relative operating characteristic curve, exhibited a significant difference in disease recurrence [estimated 5-year disease-free survival rate, 95.3% in the low-grade group versus 66.7% in the high-grade group, hazard ratio 7.35, Log-rank test p = 0.002]. The sub-grouping system is concise and suitable for practical use. It will improve the histological classification of ADC. 相似文献
977.
Michito Murayama Taisei Mikami Sanae Kaga Kazunori Okada Takuma Hioka Nobuo Masauzi Masahiro Nakabachi Hisao Nishino Shinobu Yokoyama Mutsumi Nishida Hiroyuki Iwano Mamoru Sakakibara Satoshi Yamada Hiroyuki Tsutsui 《Ultrasound in medicine & biology》2017,43(5):958-966
In our new echocardiographic method, pulmonary regurgitant velocity immediately before right atrial (RA) contraction is used to estimate pulmonary artery diastolic pressure (PADP) and mean PA wedge pressure (MPAWP). Our aim here was to compare the usefulness of this new method with that of the conventional method, which uses pulmonary regurgitant velocity at end diastole. We studied 55 consecutive patients who underwent echocardiography and right-sided heart catheterization. The pulmonary regurgitant velocities just before RA contraction and at end diastole were measured to obtain echocardiographic estimates of PADP (EPADPpreA and EPADPED, respectively) by adding the pressure gradients to the echocardiographically estimated RA pressure. Compared with EPADPED, EPADPpreA correlated better with PADP (r = 0.87) and MPAWP (r = 0.80), and direct fixed biases were detected for EPADPED but not for EPADPpreA. The area under the receiver operating characteristic curve distinguishing patients with MPAWP ≥18 mm Hg was greater for EPADPpreA (0.97) than for E/e′ (0.94) and E/A (0.83). EPADPpreA is thus useful in estimating PADP and MPAWP in patients with heart disease. 相似文献
978.
Radek Gažák Kateřina Purchartová Petr Marhol Lucie Živná Petr Sedmera Kateřina Valentová Nobuo Kato Hiroyo Matsumura Kunihiro Kaihatsu Vladimír Křen 《European journal of medicinal chemistry》2010,45(3):1059-1067
Two selective acylation methods for silybin esterification with long-chain fatty acids were developed, yielding a series of silybin 7-O- and 23-O-acyl-derivatives of varying acyl chain lengths. These compounds were tested for their antioxidant (inhibition of lipid peroxidation and DPPH-scavenging) and anti-influenza virus activities. The acyl chain length is an important prerequisite for both biological activities, as they improved with increasing length of the acyl moiety. 相似文献
979.
Aortopulmonary Artery Fistula: Ruptured Aneurysm of the Distal Aortic Arch into the Pulmonary Artery
Osamu Sasaki M.D. Toshihiko Nishioka M.D. Yoshiro Inoue M.D. Hideki Sasaki M.D. Hiroyuki Ito M.D. Nobuo Yoshimoto M.D. 《Echocardiography (Mount Kisco, N.Y.)》2013,30(3):E67-E69
Aortopulmonary artery fistula is uncommon, but the clinical outcome is often lethal. A 76‐year‐old man with a history of acute thoracic aortic dissection 6 years previously was admitted with dyspnea. A chest x‐ray showed pleural effusion and pulmonary congestion. Transthoracic echocardiography revealed preserved systolic function, but continuous and abnormal flow from the distal aortic arch into the pulmonary artery (PA). Transesophageal echocardiography (TEE) in the Doppler color‐flow mode demonstrated a left‐to‐right shunt between a large distal aortic arch aneurysm and the left PA via an aortopulmonary fistula and a pressure gradient across the shunt of 56 mmHg. Contrast‐enhanced computed tomography showed that the aneurysm compressed the PA. Aortography also revealed a large distal aortic arch aneurysm and almost simultaneous contrast enhancement of the aorta and the PA. Right‐heart catheterization showed a significant increase in oxygen saturation between the right ventricle and the PA. A left‐to‐right shunt due to a distal aortic arch aneurysm rupturing into the left PA was diagnosed based on these findings. TEE was very helpful in confirming the presence and precise location of the fistula. 相似文献
980.
Yamada K Kawata T Wada M Mori K Tamai H Tanaka N Tadokoro T Tobimatsu T Toraya T Maekawa A 《Journal of nutritional science and vitaminology》2007,53(2):95-101
We have previously reported that rats fed on a vitamin B12 (B12)-deficient diet containing 180 g soybean protein per kg diet showed marked histologic damage in their testes. In this paper, we report the effect of B12-deficiency on B12-dependent methionine synthase in the rats' testes and the effect of methionine supplementation of the diet on testicular damage. Rats were fed the soybean protein-based B12-deficient diet for 120 d. We confirmed that those rats were in serious B12-deficiency by measuring urinary methylmalonic acid excretion and B12 content in tissues. Methionine synthase activity in the testis of the B12-deficient rats was less than 2% of that in B12-supplemented (control) rats. To complement disrupted methionine biosynthesis, methionine was supplied in the diet. A supplement of 5 g D,L-methionine per kg diet to the B12-deficient diet did not affect urinary methylmalonic acid excretion of B12-deficient rats. The testicular histology of rats fed the methionine-supplemented B12-deficient diet was almost indistinguishable from that of control rats. Thus, we conclude that the lowered testicular methionine synthase activity is the primary cause of the histologic damage due to B12-deficiency and that methionine supplementation to the diet can reduce the damage. These findings would indicate the importance of the methionine synthase activity, especially for testicular function. 相似文献