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Long-term follow-up of autoantibody profiles in black female lupus patients and clinical comparison with Caucasian and Asian patients 总被引:5,自引:4,他引:1
The aim was to determine whether the autoantibody profile in Black female
lupus patients is associated with clinical subsets, fluctuates over time
and/or reflects disease activity. A clinical comparison with Caucasian and
Asian patients matched for age of onset and disease duration was also
undertaken. Up to seven serial bleeds from Black female lupus patients who
had been followed up for periods of 3.15 yr were tested for antibodies to
Ro/SSA, La SSB. Sm, RNP and ribosomal P using ELISA research assays.
Significant differences in both clinical and serological profiles between
the ethnic groups were found. Varying aspects of disease activity were
linked to anti-DNA (renal, cardiovascular, global score), anti-ribosomal P
(musculoskeletal, haematology) and anti-Sm (general) antibodies. There are
differences in clinical and serological profiles amongst systemic lupus
erythematosus patients of different ethnic origin. However, using the BILAG
system, relatively few antibodies were found to reflect disease activity
accurately in serial measurements.
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Matson GB; Twieg DB; Karczmar GS; Lawry TJ; Gober JR; Valenza M; Boska MD; Weiner MW 《Radiology》1988,169(2):541-547
Localized phosphorus-31 magnetic resonance (MR) spectroscopy in humans has previously been accomplished with surface coils by means of depth-resolved surface coil spectroscopy or rotating frame experiments, in which the extent of tissue sampled critically depends on surface coil placement. The authors' goal was to modify the surface coil image-selected in vivo spectroscopy (ISIS) experiment to accomplish three-dimensional volume selection through application of selective pulses in the presence of B0 gradients. Advantages of ISIS include the ability to use proton images to define the volume of interest (VOI) and reduced dependence on exact positioning of the surface coil. However, rapid replication of the surface coil ISIS experiment can cause spectral contamination from signals originating outside the VOI. A modified version of the ISIS experiment was developed to alleviate contamination under conditions of rapid replication. Applications of localized P-31 MR spectroscopy for observation of high-energy phosphorus metabolites are presented in human liver, heart, and transplanted and normal kidney. 相似文献
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