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911.
912.
Rodolfo Morales-Avalos Arlette Gabriela Santos-Martínez Cesia Gisela Ávalos-Fernández Karim Mohamed-Noriega Gabriela Sánchez-Mejorada Adolfo Montemayor-Alatorre David A. Martínez-Fernández Abraham G. Espinosa-Uribe Jibran Mohamed-Noriega Edgar E. Cuervo-Lozano Jesús Mohamed-Hamsho Oscar Quiroga-García Roberto A. Lugo-Guillen Santos Guzmán-López Rodrigo E. Elizondo-Omaña 《European archives of oto-rhino-laryngology》2016,273(9):2785-2793
913.
Jaime Ruiz-Tovar Lorea Zubiaga Maria Diez Ana Murcia Evangelina Boix José Luis Muñoz Carolina Llavero OBELCHE group 《Obesity surgery》2016,26(6):1221-1227
Background
Between 2 and 8 weeks before surgery, most bariatric surgery groups establish strict dietary treatments with a total caloric intake of less than 1,000 kcal/day in order to maximize weight loss during this period of time.Methods
A prospective randomized clinical trial of all the patients undergoing laparoscopic sleeve gastrectomy (LSG) was performed. Patients were randomly assigned into 3 groups: those patients receiving a preoperative regular diet of 900 kcal/day (group 1), those receiving a preoperative balanced energy high-protein formula (group 2) and those receiving preoperative Immunonutrition (group 3). Preoperative weight loss, postoperative pain, complications and analytical acute phase reactants were investigated.Results
Sixty patients were included in the study, 20 in each group. Preoperative excess weight loss was 7.7 % in group 1, 12.3 % in group 2 and 15.3 % in group 3 (p?=?0.014). Median postoperative pain was 3.5 in group 1, 3 in group 2 and 2 in group 3 (p?=?0.048). C-reactive protein determined 24 h after surgery was significantly lower in group 3 than in the other groups. AST and ALT values were significantly lower in group 3 than in the other groups, without significant differences between groups 1 and 2.Conclusions
Preoperative diet with Immunonutrition formulas during 2 weeks achieves a greater preoperative weight loss, lower postoperative pain and lower values of CRP and liver enzymes than high-protein formulas or regular diet, all of them with similar caloric intake.914.
915.
The Effect of High‐Mobility Group Box 1 in Rat Steatotic and Nonsteatotic Liver Transplantation From Donors After Brain Death 下载免费PDF全文
M. E. Cornide‐Petronio E. Negrete‐Sánchez M. Mendes‐Braz A. Casillas‐Ramírez E. Bujaldon N. Meroño L. Martínez‐Carreres J. Gracia‐Sancho J. Rodés M. B. Jiménez‐Castro C. Peralta 《American journal of transplantation》2016,16(4):1148-1159
High‐mobility group box 1 (HMGB1) has been described in different inflammatory disorders, and the deleterious effects of brain death (BD) may counteract the protection conferred by ischemic preconditioning (IP), the only surgical strategy that is being applied in clinical liver transplantation. Our study examined how HMGB1 may affect preconditioned and unpreconditioned steatotic and nonsteatotic liver grafts from donors after BD (DBDs) for transplantation. HMGB1 was pharmacologically modulated in liver grafts from DBDs, and HMGB1‐underlying mechanisms were characterized. We found that BD decreased HMGB1 in preconditioned and unpreconditioned livers and was associated with inflammation and damage. Exogenous HMGB1 in DBDs activates phosphoinositide‐3‐kinase and Akt and reduces hepatic inflammation and damage, increasing the survival of recipients. Combination of IP and exogenous HMGB1 shows additional benefits compared with HMGB1 alone. This study provides new mechanistic insights into the pathophysiology of BD‐derived liver graft damage and contributes to the development of novel and efficient strategies to ultimately improve liver graft quality. 相似文献
916.
The Relationship Between Verified Organ Donor Designation and Patient Demographic and Medical Characteristics 下载免费PDF全文
N. K. R. Sehgal C. Scallan C. Sullivan M. Cedeño J. Pencak J. Kirkland K. Scott J. D. Thornton 《American journal of transplantation》2016,16(4):1294-1297
Previous studies on the correlates of organ donation consent have focused on self‐reported willingness to donate and on self‐reported medical suitability to donate. However, these may be subject to social desirability bias and inaccurate assessments of medical suitability. The authors sought to overcome these limitations by directly verifying donor designation on driver's licenses and by abstracting comorbid conditions from electronic health records. Using a cross‐sectional study design, they reviewed the health records of 2070 randomly selected primary care patients at a large urban safety‐net medical system to obtain demographic and medical characteristics. They also examined driver's licenses that were scanned into electronic health records as part of the patient registration process for donor designation. Overall, 943 (46%) patients were designated as a donor on their driver's license. On multivariate analysis, donor designation was positively associated with age 35–54 years, female sex, nonblack race, speaking English or Spanish, being employed, having private insurance, having an income >$45 000, and having fewer comorbid conditions. These demographic and medical characteristics resulted in patient subgroups with donor designation rates ranging from 21% to 75%. In conclusion, patient characteristics are strongly related to verified donor designation. Further work should tailor organ donation efforts to specific subgroups. 相似文献
917.
Diego García-González Verónica Murcia-Belmonte Pedro F. Esteban Felipe Ortega David Díaz Irene Sánchez-Vera Rafael Lebrón-Galán Laura Escobar-Castañondo Luis Martínez-Millán Eduardo Weruaga José Manuel García-Verdugo Benedikt Berninger Fernando de Castro 《Brain structure & function》2016,221(1):239-260
New subventricular zone (SVZ)-derived neuroblasts that migrate via the rostral migratory stream are continuously added to the olfactory bulb (OB) of the adult rodent brain. Anosmin-1 (A1) is an extracellular matrix protein that binds to FGF receptor 1 (FGFR1) to exert its biological effects. When mutated as in Kallmann syndrome patients, A1 is associated with severe OB morphogenesis defects leading to anosmia and hypogonadotropic hypogonadism. Here, we show that A1 over-expression in adult mice strongly increases proliferation in the SVZ, mainly with symmetrical divisions, and produces substantial morphological changes in the normal SVZ architecture, where we also report the presence of FGFR1 in almost all SVZ cells. Interestingly, for the first time we show FGFR1 expression in the basal body of primary cilia in neural progenitor cells. Additionally, we have found that A1 over-expression also enhances neuroblast motility, mainly through FGFR1 activity. Together, these changes lead to a selective increase in several GABAergic interneuron populations in different OB layers. These specific alterations in the OB would be sufficient to disrupt the normal processing of sensory information and consequently alter olfactory memory. In summary, this work shows that FGFR1-mediated A1 activity plays a crucial role in the continuous remodelling of the adult OB 相似文献
918.
919.
920.
Retrospective cohort study of prognostic factors in patients with oral cavity and oropharyngeal squamous cell carcinoma 下载免费PDF全文