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61.
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Tsukasa Ohnishi Kiyoshi Mori Sei Ohta Kohei Yokoi Naoto Miyazawa Keigo Tominaga Mitsuru Adachi 《International journal of clinical oncology / Japan Society of Clinical Oncology》1997,2(4):235-237
Tumor lysis syndrome is a rare complication of nonhematologic malignancies that results from massive necrosis of neoplastic
cells after chemotherapy. This syndrome consists of life-threatening metabolic derangements, including severe hyperphosphatemia,
hyperkalemia, hyperuricemia, and hypocalcemia, and may result in renal failure and death if not recognized early and treated
appropriately. We report a case of tumor lysis syndrome after induction chemotherapy in a patient with widely metastatic smallcell
lung cancer. This case emphasizes the importance of awareness and early treatment of this syndrome. 相似文献
64.
There are no published data of manometric studies of pyloric motor function in patients with infantile hypertropic pyloric
stenosis (IHPS). The present study attempted to examine the characteristics of motor abnormality of the pylorus in five children
with IHPS. Using a transducer-built-in manometric catheter cannulated through the pylorus under fluoroscopy, the pressure
in the pyloric canal was recorded continuously over 3 h during fasting. Clusters of high-amplitude spastic contractions of
over 300 mmHg were recorded at intervals. The frequency was 1–3/min (mean 1.7 cpm) and the duration was 7–15 s. These periodic
spastic contractions were suppressed temporarily for 20–30 min after intravenous injection of 0.01 mg/kg atropine. After pyloromyotomy,
these spastic contractions decreased remarkably in amplitude, but there were no changes in frequency. It is concluded that
the underlying motor abnormality observed in hypertrophied pyloric muscle is clusters of high-amplitude contractions, although
more precise measurements of basal pyloric pressure are needed to explore the pathophysiology of IHPS in detail. The effect
of pyloromyotomy may be related to the decrease in high-amplitude contractions.
Accepted: 26 May 1998 相似文献
65.
Hironori Kikkawa Daisei Miyamoto Hidetoshi Imafuku Chieko Koike Yasuo Suzuki Shoji Okada Hideo Tsukada Tatsuro Irimura Naoto Oku 《Cancer science》1998,89(12):1296-1305
To elucidate the early events of blood-borne metastasis under actual blood flow, real-time trafficking of RAW117 large cell lymphoma cells, namely parental RAW117-P and liver-metastatic RAW117-H10 cells, was investigated using positron emission tomography (PET). Both types of cells accumulated in the liver immediately after injection via the portal vein, and were eliminated from the liver time-dependently. The elimination rate of RAW117-H10 cells, however, was slower than that of RAW117-P cells, suggesting that RAW117-H10 cells interact more strongly with hepatic sinusoidal endothelium than the parental cells. This result correlated with the metastatic potential of these cells: RAW117-H10 cells metastasized in the liver to a greater extent than RAW117-P cells after injection via this route. To investigate the role of sialylglycoconjugates in the interaction of RAW117-H10 cells with the hepatic endothelium after injection via the portal vein, the trafficking of RAW117-H10 cells was examined after the cells had been treated with sialidase. The elimination rate of RAW117-H10 cells from liver was observed to be greatly accelerated by sialidase treatment. To elucidate what kind of sialylglycoconjugates is related to this phenomenon, we analyzed the distribution of sialyl Lewis A and sialyl Lewis X antigens of both sublines of RAW117 by using flow cytometry. RAW117-H10 cells were found to express a much higher level of sialyl Lewis A than RAW117-P cells, whereas the amount of sialyl Lewis X did not differ significantly. These findings suggest that some sialylglycoconjugates, perhaps sialyl Lewis A in particular, play an important role in the initial interaction of RAW117-H10 cells with the hepatic endothelium, leading to metastasis. 相似文献
66.
67.
Statistical Analysis of Factors Affecting the Outcome of Patients with Ruptured Distal Anterior Cerebral Artery Aneurysms 总被引:3,自引:0,他引:3
Miyazawa N Nukui H Yagi S Yamagata Z Horikoshi T Yagishita T Sugita M 《Acta neurochirurgica》2000,142(11):1241-1246
Summary
The clinical factors affecting the outcome of patients with ruptured distal anterior cerebral artery (ACA) aneurysms were
analyzed using multiple logistic regression analysis.
The medical records were reviewed of 52 patients (57 aneurysms) with ruptured distal ACA aneurysms operated on by the same
neurosurgeon over 25 years. The standard policy was early surgery for patients in Hunt and Kosnik grades I to IV. Age, sex,
Hunt and Kosnik grade, timing of operation, size of aneurysms, number of aneurysms, association of intracerebral haemorrhage
(ICH), intraventricular haemorrhage, and azygos ACA, use of temporary clipping , occurrence of premature rupture, and presence
of psychiatric change were investigated. Univariant analysis disclosed that clinical grade (P=0.0006), size of aneurysm (P=0.005),
and size of ICH (P=0.012) affected the outcome of patients. Multiple logistic regression analysis found that Hunt and Kosnik
grade (P=0.010) and timing of operation (P=0.033) affected the outcome. There was no significant relationship between long-term
outcome and clinical factors, although a close relationship was found with Hunt and Kosnik grade (P=0.071).
Clinical grade and timing of the operation affected the outcome of patients with ruptured distal ACA aneurysms. Patients
harboring ICH of over 3 cm diameter in poor grades should also be carefully treated. 相似文献
68.
Total parenteral nutrition-associated intrahepatic cholestasis in infants: 25 years' experience 总被引:10,自引:0,他引:10
Kubota A Yonekura T Hoki M Oyanagi H Kawahara H Yagi M Imura K Iiboshi Y Wasa K Kamata S Okada A 《Journal of pediatric surgery》2000,35(7):1049-1051
BACKGROUND/PURPOSE: There are few long-term chronological reviews examining the incidence of total parenteral nutrition (TPN)-associated intrahepatic cholestasis (TPNAC) in infants. The authors therefore reviewed TPNAC in their 25-year series, and also looked at the current problems associated with TPN in infants. METHODS: Two hundred seventy-three surgical neonates who received TPN for more than 2 weeks were divided into 3 groups chronologically: group A (1971 through 1982, n = 77), group B (1983 through 1987, n = 72), and group C (1992 through 1996, n = 124). TPNAC was defined as serum direct bilirubin (DB) level greater than 2.0 mg/dL during the neonatal period. RESULTS: The incidence of TPNAC in groups A, B and C was 57%, 31%, and 25% (P< .01), respectively, and the mortality rate from TPN-associated complications was 13%, 3%, and 3% (P< .05), respectively. Over the last 5 years, severe TPNAC developed in 20 patients (16%). Four of 20 died of TPN-associated sepsis with hepatic failure; 2 had hypoganglionosis with intractable stagnant enteritis and subsequent sepsis, and 2 had fatal respiratory or cardiac disease. CONCLUSIONS: The incidence of TPNAC in surgical neonates and TPN-associated mortality rates have decreased significantly. The mortality rate, however, still remains at 3%. Two of 4 fatal cases had hypoganglionosis, which were totally dependent on TPN. In patients who require long-term TPN, TPN still has unsolved problems, and small bowel transplantation may be indicated. 相似文献
69.
Measurement of serum hyaluronic acid as a sensitive marker of liver fibrosis in biliary atresia 总被引:4,自引:0,他引:4
Hasegawa T Sasaki Kimura T Hoki M Okada A Mushiake S Yagi M Imura K 《Journal of pediatric surgery》2000,35(11):1643-1646
PURPOSE: The aim of this study was to clarify whether serum hyaluronic acid level (SHA) can reflect the degree of liver fibrosis in biliary atresia (BA). METHODS: SHA was measured in 44 postoperative BA patients at 7 months to 22 years of age, with sandwich enzyme method (Hy-A 100 kit). SHA was compared with T.Bil (group 1, T Bil < 2; group 2, 2 < or = T Bil < 5; group 3, T Bil > or = 5 mg/dL), fibrosis score (0-6, the number of abnormal values among Alb, PT, ChE, T Chol, Fischer's ratio, prealbumin), and histologic grading (0-IV). RESULTS: SHA was 499.8 +/- 332.5 in group 3, significantly higher than in the control, group 1, or group 2. As fibrosis score rose, SHA became higher, and SHA in Score 6 (430.1 +/- 366.1 ng/mL) and score-5 (172.9 +/- 141.8 ng/mL) was significantly higher than in the control and other scores, respectively. As the histologic grade rose, SHA became higher, and SHA in grade IV (444.8 +/- 323.5 ng/mL) and grade III (166.0 +/- 70.3 ng/mL) was significantly higher than in the control or other Grades. Serial change of SHA since before HPE was parallel to the clinical course in 8 patients. CONCLUSION: SHA may be a useful serum marker reflecting the degree of liver fibrosis in BA. 相似文献
70.
Serum interleukin-18 levels are elevated in schizophrenia 总被引:6,自引:0,他引:6
Interleukin-18 (IL-18) is a recently discovered proinflammatory cytokine which plays a pivotal role in T helper 1 (Th1) responses. IL-18 is produced by macrophage-like cells, and inappropriate IL-18 production has been known to be involved in immunological disturbances. Schizophrenia is a common disease whose pathogenesis is still unclear; however, an activation of the inflammatory response system, including the Th1 cytokine response, may be related to the pathophysiology of schizophrenia. We measured the serum IL-18 levels of 66 schizophrenics and age- and sex-matched control subjects by using an ELISA assay. We found significantly increased serum IL-18 levels in the schizophrenic patients (P=0.0002). This finding supports the hypothesis that immune activation is involved in the pathophysiology of schizophrenia. 相似文献