全文获取类型
收费全文 | 3921篇 |
免费 | 187篇 |
国内免费 | 86篇 |
专业分类
耳鼻咽喉 | 42篇 |
儿科学 | 89篇 |
妇产科学 | 54篇 |
基础医学 | 411篇 |
口腔科学 | 157篇 |
临床医学 | 300篇 |
内科学 | 955篇 |
皮肤病学 | 60篇 |
神经病学 | 196篇 |
特种医学 | 333篇 |
外科学 | 581篇 |
综合类 | 26篇 |
一般理论 | 1篇 |
预防医学 | 219篇 |
眼科学 | 69篇 |
药学 | 268篇 |
中国医学 | 4篇 |
肿瘤学 | 429篇 |
出版年
2023年 | 24篇 |
2022年 | 39篇 |
2021年 | 56篇 |
2020年 | 28篇 |
2019年 | 50篇 |
2018年 | 62篇 |
2017年 | 44篇 |
2016年 | 49篇 |
2015年 | 52篇 |
2014年 | 93篇 |
2013年 | 114篇 |
2012年 | 129篇 |
2011年 | 154篇 |
2010年 | 112篇 |
2009年 | 93篇 |
2008年 | 153篇 |
2007年 | 191篇 |
2006年 | 158篇 |
2005年 | 168篇 |
2004年 | 159篇 |
2003年 | 145篇 |
2002年 | 176篇 |
2001年 | 153篇 |
2000年 | 178篇 |
1999年 | 150篇 |
1998年 | 90篇 |
1997年 | 74篇 |
1996年 | 54篇 |
1995年 | 61篇 |
1994年 | 57篇 |
1993年 | 46篇 |
1992年 | 98篇 |
1991年 | 95篇 |
1990年 | 64篇 |
1989年 | 98篇 |
1988年 | 76篇 |
1987年 | 69篇 |
1986年 | 74篇 |
1985年 | 69篇 |
1984年 | 50篇 |
1983年 | 40篇 |
1982年 | 25篇 |
1981年 | 25篇 |
1979年 | 33篇 |
1978年 | 27篇 |
1977年 | 30篇 |
1976年 | 27篇 |
1975年 | 28篇 |
1974年 | 21篇 |
1972年 | 21篇 |
排序方式: 共有4194条查询结果,搜索用时 0 毫秒
11.
S Nakata K Imai T Uchida H Yamanaka K Hashimoto H Ogura K Nakano M Kurita Y Saito Y Ono 《Hinyokika kiyo. Acta urologica Japonica》1991,37(10):1261-9; discussion 1269-70
Prostatic cancer is one of the most common malignant tumors in the field of urology. The number of patients is increasing rapidly and its importance as a mortal disease is gathering attention. In 1985, we organized a registration system for prostatic cancer patients found in and around Gunma prefecture. In this study, we analyzed the clinical characteristics of the 730 patients registered from 1985 to 1989. The results were as follows. Mean age was 74.0 years old and the number of the patients was the greatest in the eighth decade. Voiding disturbance was the most common chief complaint, followed by pollakisuria, gross hematuria and miction pain. Stage and grade distribution were as follows. Stage A 16.2%, B 21.1%, C 17.0%, D 45.7%, well differentiated 27.4%, moderately differentiated 48.2% and poorly differentiated 24.5%, respectively. A statistically significant relationship between stage and grade was observed. Bone was the most common metastatic site. The highest incidence of bone metastasis was in lumbar vertebra, followed by ribs, ilium, thoracic vertebra and ischium. The value of PAP, ALP and ESR tended to be higher in high stage patients, and that of Hb was lower. Fifty two patients were detected by mass screening. Most of these patients were in an early stage. Most of the patients were treated by hormonal therapy. LH-RH agonists constituted 39.2% of the cases given hormonal therapy. 相似文献
12.
13.
This study was undertaken into rats to investigate changes in the hepatic lymph vessels and the space of Disse in endotoxaemia and to examine their relationship with the development of endotoxin-induced hepatic injury. Lymph stasis, namely dilatation of the lymph vessels and oedema, developed rapidly in the medium-sized portal canals, the large portal canals, and the liver hilum after endotoxin injection, but not in the small portal canals. Such changes reached their maximum 4-8 h after endotoxin injection and had recovered markedly by 16 h after the injection. The space of Disse remained within normal limits during this period. These findings suggest that the intrahepatic lymph stasis in endotoxaemia may be caused by a reduction in the pumping activity of the extrahepatic and the intrahepatic large lymph vessels rather than by an increase of lymph formation in the liver lobules. There was no evidence suggesting a direct relationship between the disturbance of hepatic lymph flow and the development of hepatic injury in endotoxaemia. 相似文献
14.
G Tanaka J Shojima I Matsushita H Nagai A Kurashima K Nakata E Toyota N Kobayashi K Kudo N Keicho 《The European respiratory journal》2007,30(1):90-96
The present study aimed to elucidate risk factors for nonimmunocompromised pulmonary Mycobacterium avium complex (MAC) infection. Epidemiological data and variations of candidate genes for mycobacterial diseases were analysed in 111 patients with pulmonary MAC infection. Four polymorphisms of the human natural resistance-associated macrophage protein (NRAMP)1 gene, the 5'(GT)n, 469+14 G/C, D543N and the 3'untranslated region (3'TGTG) insertion/deletion, were genotyped using PCR-based methods. Fok I and Taq I polymorphisms of the vitamin D receptor gene and -221 X/Y and codon 54 A/B polymorphisms of the mannose binding lectin gene were also evaluated. Females were more susceptible to MAC infection mainly affecting the right middle lobe or lingular segment of the lung. Patients' residence at the onset of the disease was distributed evenly irrespective of a waterfront or city water supply system. As compared with homozygotes for major alleles of the D543N and TGTG insertion/deletion polymorphism of the NRAMP1 gene, heterozygotes containing minor alleles were less often observed in MAC cases than in controls. This genetic effect was more significant in patients without comorbidity but not in patients with comorbidity. Other polymorphisms did not show any association with the MAC infection. The human natural resistance-associated macrophage protein 1 gene might be involved in susceptibility to pulmonary Mycobacterium avium complex infection. 相似文献
15.
Takashi Murakami Hitoshi Horigome Kiyoji Tanaka Yoshio Nakata Yasutomi Katayama Akira Matsui 《Blood coagulation & fibrinolysis》2007,18(5):389-394
Obesity is a risk factor for cardiovascular disease and thromboembolic events. We investigated the effects of weight reduction by a 12-week calorie-restricted diet with or without aerobic exercise (diet group and diet plus exercise group) on leptin and anticoagulation proteins levels. Forty-two obese nondiabetic individuals were evaluated for blood levels of leptin, protein C activity, free protein S antigen and for body fat area calculated on computerized tomography before and after intervention. Before intervention, serum levels of leptin and free protein S antigen correlated positively with several adiposity-related parameters. After the program, body weight and fat area were significantly decreased in both groups. Body mass index and leptin levels decreased in both groups, with a larger change in the diet plus exercise group than in the diet group. Although protein C activity levels did not change in both groups, free protein S antigen levels decreased significantly in the diet plus exercise group. In conclusion, the 12-week programs had significant effects on the initial weight reduction and body fat mass, decreasing lepin levels in obese nondiabetic individuals. To clarify whether aerobic exercise has additional or direct effects on the anticoagulation system, a study in a large number of individuals is needed. 相似文献
16.
17.
Aim: This study aims to establish a pressure ulcers model that visualizes the microcirculation, and to examine the participation of ischemia‐reperfusion injury in the pathophysiology of pressure ulcers.
Methods: An original system composed of a new skinfold chamber and compression device allowed loading quantitative vertical stress to the skin. An intravital microscopic technique enabled direct visualization of the microcirculation in the physiological condition and in response to pressure application. To estimate the effect of ischemia‐reperfusion injury, animals were divided into two groups: the compression‐release group in which the animals received four cycles of compression‐release which consisted of 2 hours of compression followed by 1 hour of pressure release; and the compression alone group in which the animals underwent continuous compression for 8 hours. Functional capillary density was quantified before the compression procedure and on day1 (35 hours) after the first evaluation.
Results and Conclusions: The cyclic compression‐release procedure significantly decreased functional capillary density as compared to continuous compression, indicating that in our experimental setting repetition of ischemia‐reperfusion cycle more severely damaged the microcirculation than single prolonged ischemic insult. The finding supports the significant contribution of ischemia‐reperfusion injury to the pathophysiology of pressure ulcers at the level of dynamic in vivo microcirculation. 相似文献
Methods: An original system composed of a new skinfold chamber and compression device allowed loading quantitative vertical stress to the skin. An intravital microscopic technique enabled direct visualization of the microcirculation in the physiological condition and in response to pressure application. To estimate the effect of ischemia‐reperfusion injury, animals were divided into two groups: the compression‐release group in which the animals received four cycles of compression‐release which consisted of 2 hours of compression followed by 1 hour of pressure release; and the compression alone group in which the animals underwent continuous compression for 8 hours. Functional capillary density was quantified before the compression procedure and on day1 (35 hours) after the first evaluation.
Results and Conclusions: The cyclic compression‐release procedure significantly decreased functional capillary density as compared to continuous compression, indicating that in our experimental setting repetition of ischemia‐reperfusion cycle more severely damaged the microcirculation than single prolonged ischemic insult. The finding supports the significant contribution of ischemia‐reperfusion injury to the pathophysiology of pressure ulcers at the level of dynamic in vivo microcirculation. 相似文献
18.
Y. Watanabe M. Sato T. Lee Y. Abe Y. Nakata H. Kashu S. Iseki Y. Mizukami S. Kimura 《HPB surgery》1996,9(2):107-111
A 75-year-old man who was diagnosed as having mucin-producing pancreatic cystic lesion ofthe
main pancreatic duct by duodenoscopic examination was reported. Because of the low
malignant potential of such lesions, duodenum-preserving resection of the head of the pancreas
was performed, and the intra-operative histological examination showed no malig-nancy of the
resected pancreatic head and no other surgical procedures, such as lymph-adenectomy nor
pancreato-duodenectomy were necessary. The significance of this case report lies in that a less
invasive operation should be selected at first to diagnose whether the lesion is malignant or not,
and als0 that the selected operation itself must be sufficient to resect an adequate part of the
pancreatic tissue involving the cystic lesion, ifnot malignant. Here, we report the process to select
the procedure and the surgical technique. 相似文献
19.
20.
Electrocardiogram in a 15-year-old girl showed persistent supraventricular tachycardia at rates of 130 to 140 bpm. Electrophysiological study confirmed left atrial automatic tachycardia, which was transferred to sinus rhythm by intravenous infusion of aprindine (100 mg/10 min). Therefore, aprindine (60 mg/day) was administered orally, and neither recurrence of left atrial automatic tachycardia nor side effects were observed during subsequent follow-up period of 16 months. 相似文献