全文获取类型
收费全文 | 5835篇 |
免费 | 379篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 73篇 |
儿科学 | 327篇 |
妇产科学 | 77篇 |
基础医学 | 761篇 |
口腔科学 | 176篇 |
临床医学 | 404篇 |
内科学 | 1329篇 |
皮肤病学 | 95篇 |
神经病学 | 428篇 |
特种医学 | 197篇 |
外科学 | 626篇 |
综合类 | 176篇 |
一般理论 | 1篇 |
预防医学 | 378篇 |
眼科学 | 114篇 |
药学 | 429篇 |
中国医学 | 52篇 |
肿瘤学 | 581篇 |
出版年
2023年 | 22篇 |
2022年 | 76篇 |
2021年 | 203篇 |
2020年 | 97篇 |
2019年 | 125篇 |
2018年 | 137篇 |
2017年 | 92篇 |
2016年 | 118篇 |
2015年 | 130篇 |
2014年 | 197篇 |
2013年 | 271篇 |
2012年 | 413篇 |
2011年 | 379篇 |
2010年 | 225篇 |
2009年 | 186篇 |
2008年 | 261篇 |
2007年 | 274篇 |
2006年 | 238篇 |
2005年 | 247篇 |
2004年 | 222篇 |
2003年 | 216篇 |
2002年 | 192篇 |
2001年 | 166篇 |
2000年 | 171篇 |
1999年 | 163篇 |
1998年 | 76篇 |
1997年 | 70篇 |
1996年 | 50篇 |
1995年 | 60篇 |
1994年 | 42篇 |
1993年 | 44篇 |
1992年 | 107篇 |
1991年 | 81篇 |
1990年 | 87篇 |
1989年 | 93篇 |
1988年 | 80篇 |
1987年 | 72篇 |
1986年 | 60篇 |
1985年 | 56篇 |
1984年 | 49篇 |
1983年 | 44篇 |
1982年 | 25篇 |
1981年 | 22篇 |
1979年 | 40篇 |
1978年 | 27篇 |
1977年 | 17篇 |
1976年 | 17篇 |
1974年 | 22篇 |
1973年 | 22篇 |
1970年 | 23篇 |
排序方式: 共有6224条查询结果,搜索用时 15 毫秒
91.
92.
93.
94.
95.
Kiran Gangadhar Kedar N. Chintapalli Gilbert Cortez Sandhya Vinu Nair 《The Egyptian Journal of Radiology and Nuclear Medicine》2014
Intracellular fat accumulation is a common feature of liver disease. Steatosis is the histological hallmark of non-alcoholic fatty liver disease (NAFLD) but also may occur with alcohol abuse, viral hepatitis, HIV and genetic lipodystrophies, and chemotherapy. This condition is common in the Western population and is typically associated with obesity and the metabolic syndrome. Early diagnosis and early treatment of NAFLD are important to prevent the development of end-stage liver disease and cancer. In addition, liver fat is a risk factor for postoperative complications after liver resection and transplantation. MRI has become a primary modality to assess hepatic steatosis, both qualitatively and quantitatively. In this article we discuss various MRI methods for evaluation of hepatic steatosis. 相似文献
96.
97.
Mohamed I. Husseiny Jeffrey Rawson Alexander Kaye Indu Nair Ivan Todorov Michael Hensel Fouad Kandeel Kevin Ferreri 《Vaccine》2014
Type 1 diabetes (T1D) is a metabolic disease that is initiated by the autoimmune destruction of pancreatic insulin-producing beta cells that is accompanied by the development of antigen-specific antibodies and cytotoxic T lymphocytes (CTLs). Several studies have shown that vaccination with diabetic autoantigens provides some protection against this process. In this report we describe a new oral vaccine that utilizes live attenuated Salmonella for simultaneous delivery of autoantigens in conjunction with immunomodulatory cytokine genes to immune cells in the gut mucosa. Recent data showed that live attenuated Salmonella is a safe, simple and effective vector for expression of antigens and cytokines by antigen-presenting cells (APCs) of gut-associated lymphatic tissue (GALT). This novel strategy was tested by fusion of the diabetic autoantigen preproinsulin with Salmonella secretory effector protein (SseF) of pathogenicity island-2 (SPI2). In this way the autoantigen is only expressed inside the host immune cells and translocated to the host cell cytosol. In addition Salmonella was used to deliver the gene for the immunomodulatory cytokine transforming growth factor beta (TGFβ) for host cell expression. Oral co-vaccination of 8 week-old non-obese diabetic (NOD) mice with three weekly doses of both the autoantigen and cytokine significantly reduced the development of diabetes, improved the response to glucose challenge, preserved beta cell mass, and reduced the severity of insulitis compared with controls and autoantigen alone. Combination therapy also resulted in increased circulating levels of IL10 four weeks post-vaccination and IL2 for 12 weeks post-vaccination, but without effect on proinflammatory cytokines IL6, IL12(p70), IL17 and IFNγ. However, in non-responders there was a significant rise in IL12 compared with responders. Future studies will examine the mechanism of this vaccination strategy in more detail. In conclusion, Salmonella-based oral vaccines expressing autoantigens combined with imunomodulatory cytokines appears to be a promising therapy for prevention of T1D. 相似文献
98.
99.
100.