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Aggarwal V Kapoor PM Choudhury M Kiran U Chowdhury U 《Annals of cardiac anaesthesia》2012,15(1):26-31
Sonoclot analysis is a point of care test to monitor the coagulation process, presenting a comprehensive evaluation of the clot formation and retraction as well as platelet function. This randomized double-blinded study was designed to investigate the utility of Sonoclot analysis in monitoring the coagulation profile as also the antifibrinolytic effects of tranexamic acid administered in patients with tetralogy of Fallot undergoing intracardiac repair. Eighty of a total 94 patients were randomly divided into two groups of 40 each. In the study group, TA was administered thrice at a dosage of 10 mg/kg, i.e. before CPB, on CPB and after CPB, whereas in the control group, placebo was administered at the same time intervals. Sonoclot analysis and D-dimer measurement were performed at baseline and following heparin neutralisation. An additional variable, DR?? (diminishing rate of clot strength at 15 min postmaximal clot strength), was calculated from the Sonoclot graph and was compared with d-dimer levels as a measure of fibrinolysis. The three Sonoclot variables, i.e. activated clotting time, clot rate and platelet function, were deranged at baseline in all the patients. Post-CPB, the change in these variables was not significant. ACT, clot rate and platelet function showed no significant (P > 0.05) difference in both the groups at both the time intervals. DR?? and d-dimer values were comparable at baseline in both the groups. However, a significant (P < 0.05) difference was seen in these variables in the control group as compared with the TA group following heparin neutralisation. To conclude, Sonoclot analysis is a useful, point of care method for the monitoring of coagulation and fibrinolysis in patients with tetralogy of Fallot undergoing intracardiac repair. 相似文献
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Tachycardia has been associated with worse outcomes for patients with heart failure and is also thought to have a direct adverse
impact on the myocardium. This report highlights the current evidence for heart rate as both a risk factor and mediator for
poor outcome for patients with heart failure. We summarize the large number of studies evaluating heart rate in patients with
systolic dysfunction and newer studies that examine patients with preserved systolic function. The effect on outcomes in heart
failure of medications known to slow the heart rate such as β-blockers and the more recently developed drug ivabradine are
discussed. The data clearly show that a high heart rate is a marker of increased mortality. There is also a strong suggestion
that a higher heart rate directly worsens outcome and that this can be mitigated by heart rate–reducing medications. 相似文献
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Adrian S. Fairey Wassim Kassouf Eric Estey Simon Tanguay Ricardo Rendon David Bell Jonathan Izawa Joseph Chin Anil Kapoor Edward Matsumoto Peter Black Alan So Jean‐Baptiste Lattouf Fred Saad Darrel Drachenberg Ilias Cagiannos Louis Lacombe Yves Fradet Niels‐Erik B. Jacobsen 《BJU international》2013,112(6):791-797
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