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排序方式: 共有235条查询结果,搜索用时 31 毫秒
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The present study was designed to investigate the potential protective effect of melatonin against the renal toxicity of fumonisin in female rats. Six groups of animals were used in this study. The first group served as control. The second group was given melatonin only at a dose level of 10 mg/kg. The third group was fed ration contaminated with fumonisin (100 mg/kg diet). The fourth group was fed ration contaminated with fumonisin (200 mg/kg diet). The fifth group was given daily interperitoneal injection (IP) 10 mg/kg melatonin and fed ration contaminated with fumonisin (100 mg/kg diet). The sixth group was given daily interperitoneal injection of 10 mg/kg melatonin and fed ration contaminated with fumonisin (200 mg/kg diet). The rats were treated for 1 month. Histopathological and histochemical changes in the kidney were investigated. In addition, DNA ploidy was measured in the kidney. Fumonisin administration (100 or 200 mg/Kg diet) to unpretreated control rats caused extensive renal damage as evaluated by histopathology, histochemistry, and/or DNA ploidy measurement. No apparent changes following administration of melatonin. Melatonin coadministration to the fumonisin-administered rats reduced kidney damage and the tissues appeared more or less like the normal. The present study indicates that melatonin has a protective effect in fumonisin-induced renal damage. 相似文献
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35.
Treatment of benign bone tumours using external fixation 总被引:1,自引:0,他引:1
Tsuchiya H Morsy AF Matsubara H Watanabe K Abdel-Wanis ME Tomita K 《The Journal of bone and joint surgery. British volume》2007,89(8):1077-1083
We present a retrospective study of patients suffering from a variety of benign tumours in whom external fixators were used to treat deformity and limb-length discrepancy, and for the reconstruction of bone defects. A total of 43 limbs in 31 patients (12 male and 19 female) with a mean age of 14 years (2 to 54) were treated. The diagnosis was Ollier's disease in 12 limbs, fibrous dysplasia in 11, osteochondroma in eight, giant cell tumour in five, osteofibrous dysplasia in five and non-ossifying fibroma in two. The lesions were treated in the tibia in 19 limbs, in the femur in 16, and in the forearm in eight. The Ilizarov frame was used in 25 limbs, the Taylor Spatial Frame in seven, the Orthofix fixator in six, the Monotube in four and the Heidelberg fixator in one. The mean follow-up was 72 months (22 to 221). The mean external fixation period was 168 days (71 to 352). The mean external fixation index was 42 days/cm (22.2 to 102.0) in the 22 patients who required limb lengthening. The mean correction angle for those with angular deformity was 23 degrees (7 degrees to 45 degrees ). At final follow-up all patients had returned to normal activities. Four patients required a second operation for recurrent deformity of further limb lengthening. Local recurrence occurred in one patient, requiring further surgery. 相似文献
36.
Background
Plantar ulcers pose a frequent serious complication in the neuropathic foot. Previous studies suggested that ulcer initiation occurs within the plantar soft tissue rather than on the plantar surface. This study investigated the effectiveness of different shaped silicone insoles on the reduction of both plantar soft tissue strain and pressure. The authors have found no previous experimental studies on the effectiveness of insole shape on reducing plantar soft tissue strain during standing.Methods
A custom molded silicone insole which allowed passage of ultrasound to the plantar surface of the foot was prototyped for this study. Soft tissue strain was computed from soft tissue thickness measured using ultrasound in five conditions: unloaded, barefoot, wearing a prefabricated silicone insole, wearing the custom molded silicone insole alone then with a metatarsal pad. Plantar pressure was measured for the same conditions.Findings
The custom molded insole was found to significantly reduce soft tissue strain and plantar pressure relative to both the barefoot condition and the prefabricated insole under the second and third metatarsal heads. The metatarsal pad was found to significantly reduce soft tissue strain but not significantly affect plantar pressure.Interpretation
A custom molded silicone insole can effectively reduce both soft tissue strain and plantar pressure and is thus preferable to a prefabricated insole. It is suggested that quantifying the reduction of soft tissue strain is an essential design requirement for orthotic insoles since plantar pressure may not be a sufficient indicator of the effectiveness of an insole in preventing ulcer initiation. 相似文献37.
Abdel-Ghaffar F Bashtar AR Morsy K Mehlhorn H Al Quraishy S Al-Rasheid K Abdel-Gaber R 《Parasitology research》2012,110(2):741-752
One hundred three out of 225 (45.8%) of the Red Sea fish Saurida tumbil were infected with microsporidian parasites. The infection was recorded as tumor-like masses (whitish macroscopic cysts)
or xenomas often up to 2 cm in diameter and embedded in the peritoneal cavity. Generally, the infection was increased during
winter 63.8% (86 out of 135) and fall to 18.9% (17 out of 90) in summer. Light microscopic study revealed that xenomas were
encapsulated by a fibrous layer encircling numerous sporophorous vesicles filled with mature spores measuring 1.7 ± 0.6 (1.5–2.7 μm) × 1.5 ± 0.3 μm
(1.2–1.8 μm) in size. Ultrastructural microscopic study showed the presence of smooth membranes of the sarcoplasmic reticulum
forming a thick, amorphous coat surrounding various developmental stages of the parasite. The various recognizable stages
of the parasite were uninuclear, binucleated, and multinucleated meronts followed by detachment of the plasmalemma of the
sporont from the sporophorous vesicle producing sporoblasts. Mature spores consist of a spore coat and spore contents. The
spore contents consist of the uninucleated sporoplasm and a posterior vacuole located at the posterior end. The polar tube
consists of a straight shaft and a coiled region (26–32 coils) arranged in many rows along the inside periphery of the spore.
The polaroplast consisted of an anterior region of closely and loosely packed membranes. Molecular analysis based on the small
subunit rDNA gene was performed to determine the phylogenetic position of the present species. The percentage identity between
this species and a range of other microsporidia predominantly from aquatic hosts demonstrated a high degree of similarity
(>92%) with eight Pleistophora species. Comparison of the nucleotide sequences and divergence showed that the sequence of the present microsporidium was
most similar to that of Pleistophora anguillarum (99.8% identity) differing in 13 nucleotide positions. So, the present species was recorded and phylogenetically positioned
as a new species of Pleistophora. 相似文献
38.
Mohamed-Mofeed Fawaz Morsy Nada Abdelmohsen Mohamed Abdelaziz Ahmed Mohamed Boghdady Hydi Ahmed Essam Mohamed Abu Elfadl Mohamed Ali Ismail 《Rheumatology international》2011,31(1):17-21
Angiotensin converting enzyme (ACE) gene polymorphism was previously studied in some cardiovascular diseases. There are only
few studies which investigated this polymorphism in patients with rheumatic heart disease (RHD). The results of these investigations
are inconsistent. Furthermore, gene polymorphism distribution is different in various ethnic populations. We conducted this
study to demonstrate this gene polymorphism in Egyptian children with RHD. Leukocytes DNA was extracted from 139 patients
with RHD and 79 healthy control children. After amplification by the PCR, the products were separated by electrophoresis in
6% polyacrylamide gel and visualized after ethidium bromide staining with UV light. The PCR product is a 190-bp fragment in
the absence of the insertion (D allele) and a 490-bp fragment in the presence of the insertion (I allele). Gene polymorphism
was as follows: DD gene when lane contains only 190-bp fragment, II gene when lane contains only 490-bp fragment and ID gene
when lane contains both fragments. We found that gene polymorphism in both control and patients groups followed the following
order of distribution from highest to lowest: ID, II, DD gene. The frequency in control group was 49.4, 36.7, and 13.9%, respectively.
In patients groups, the gene frequency was 42.5, 30.9, and 26.6%, respectively. DD gene frequency differs significantly between
the two groups. We concluded that patients with RHD have a higher ACE-DD genotype than normal control. ACE-DD genotype may
be a risk factor for RHD in Egyptian children. 相似文献
39.
Kareem Morsy Abdel-Rahman Bashtar Nesma Mostafa Somaya El Deeb Salwa Thabet 《Parasitology research》2015,114(3):1119-1128
40.