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91.
Immunoblotting of a repertoire of sperm antigens reacting with antisperm antibodies present in sera of infertile adults and prepubertal boys with testicular failure was performed. In the subgroups selected for this study, 55% of examined infertile women, 65% of infertile men and 64% of prepubertal boys with gonadal failure gave positive results by Western blotting with extracted sperm antigens. Sperm antigens with molecular weights of 57, 58, 62, 63 and 66 kDa were the most immunodominant entities recognized by antisperm antibodies from prepubertal boys. No positive reactions were detected by Western blotting in a control population of fertile adults, whereas in a group of prepubertal healthy boys only one sample revealed reactivity against sperm antigens of 58 and 70 kDa. 相似文献
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M. Respondek A. Włoch P. Kaczmarek D. Borowski J. Wilczynski E. Helwich 《Pediatric cardiology》1997,18(5):361-366
Fifty fetuses referred to the Polish Mother's Memorial Hospital for fetal echocardiography between January 1, 1991 and June
1, 1995 were evaluated. The mean fetal gestational age at the time of diagnosis of arrhythmia was 34.1 weeks, and the mean
gestational age at the time of delivery was 38.7 weeks. Checkup echocardiographic examinations were performed every 10–14
days, for a mean 2.4 studies per fetus. In most cases (48/50, 96%), premature atrial contractions were present during the
first echocardiography examination. The fetal heart study was normal in 30 cases; in 7 (14%) there was tricuspid valve regurgitation,
in 7 (14%) an atrial septal aneurysm, in 4 congenital heart defects, in 1 myocardial hypertrophy, and in 1 disproportion in
the four-chamber view. Of the 50 fetuses, 43 underwent regular echocardiographic monitoring alone; in 7 cases, based on the
presence of additional echocardiographic findings, pharmacotherapy was applied (digoxin, verapamil, or both). Three neonates
died after delivery owing to malformations in two cases (one critical aortic stenosis, one spina bifida plus hygroma colli)
and due to myocarditis in one case. In six of seven newborns treated in utero, myocarditis was diagnosed after birth (including
the one with neonatal demise). Most of the newborns were in good condition after birth, their mean Apgar score being 8.6 and
the mean birth weight 3259 g. We concluded that most extrasystoles represent an isolated anomaly, not affecting the fetal
condition. Their presence should not influence the obstetric care and may require only echocardiographic monitoring. In most
of our cases the premature contractions subsided after birth, although sometimes they preceded fetal supraventricular tachycardia
or appeared after congenital myocarditis. 相似文献
98.
Results of altered therapy schedules obtained in postoperative treatment of 294 patients with malignant gliomas over last 20 years are presented. During this period 135 patients received Conventional Irradiation and Chemotherapy (CICH), 61 patients received Conventional Irradiation (CI), 59 patients received Split Course High Fractional Dose Irradiation (SCHFDI), and 39 patients received Twice a Day Accelerated Irradiation (TDAI). Actuarial survival rates at 2, 3 and 5 years were 19%, 7%, 0% respectively for patients treated with CICH, and they were 21%, 10%, 0% for CI group, 24%, 12%, 0% for SCHFDI option and 15%, 8%, 0% for TDAI schedule. According to the Cox proportional hazard model, only age was significant factor in prognosis. 相似文献
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