全文获取类型
收费全文 | 1470篇 |
免费 | 97篇 |
国内免费 | 25篇 |
专业分类
儿科学 | 145篇 |
妇产科学 | 14篇 |
基础医学 | 135篇 |
口腔科学 | 68篇 |
临床医学 | 144篇 |
内科学 | 340篇 |
皮肤病学 | 38篇 |
神经病学 | 24篇 |
特种医学 | 328篇 |
外科学 | 80篇 |
综合类 | 21篇 |
预防医学 | 61篇 |
眼科学 | 16篇 |
药学 | 87篇 |
1篇 | |
中国医学 | 1篇 |
肿瘤学 | 89篇 |
出版年
2023年 | 2篇 |
2022年 | 4篇 |
2021年 | 13篇 |
2020年 | 8篇 |
2019年 | 12篇 |
2018年 | 23篇 |
2017年 | 17篇 |
2016年 | 22篇 |
2015年 | 31篇 |
2014年 | 26篇 |
2013年 | 48篇 |
2012年 | 10篇 |
2011年 | 12篇 |
2010年 | 40篇 |
2009年 | 79篇 |
2008年 | 19篇 |
2007年 | 40篇 |
2006年 | 38篇 |
2005年 | 30篇 |
2004年 | 21篇 |
2003年 | 25篇 |
2002年 | 20篇 |
2001年 | 20篇 |
2000年 | 21篇 |
1999年 | 31篇 |
1998年 | 101篇 |
1997年 | 117篇 |
1996年 | 112篇 |
1995年 | 77篇 |
1994年 | 82篇 |
1993年 | 98篇 |
1992年 | 17篇 |
1991年 | 17篇 |
1990年 | 18篇 |
1989年 | 44篇 |
1988年 | 40篇 |
1987年 | 26篇 |
1986年 | 32篇 |
1985年 | 31篇 |
1984年 | 17篇 |
1983年 | 15篇 |
1982年 | 19篇 |
1981年 | 34篇 |
1980年 | 20篇 |
1979年 | 8篇 |
1978年 | 8篇 |
1977年 | 21篇 |
1976年 | 19篇 |
1975年 | 6篇 |
1970年 | 1篇 |
排序方式: 共有1592条查询结果,搜索用时 15 毫秒
991.
MV De Gálvez Aranda † P Sánchez Sánchez † MJ Alonso Corral ‡ RJ Bosch García † MA Gallardo † E Herrera Ceballos† 《Journal of the European Academy of Dermatology and Venereology》2001,15(4):337-339
Acne caused by amineptine has always been described with typical characteristic clinical features, and the retentional and cutaneous lesions are dose related. We present a case of acne-like eruption due to amineptine in a woman under treatment for chronic depression. 相似文献
992.
993.
Involvement of polyamines in selenomethionine induced apoptosis and mitotic alterations in human tumor cells 总被引:5,自引:1,他引:4
Redman C; Xu MJ; Peng YM; Scott JA; Payne C; Clark LC; Nelson MA 《Carcinogenesis》1997,18(6):1195-1202
The efficacy of dietary selenium supplementation is currently being
evaluated in intervention trials. However, the biological mechanisms
underlying the cancer chemopreventive effects of selenium supplementation
have yet to be elucidated. Selenium metabolism and polyamine biosynthesis
are linked in their common requirement for S- adenosylmethionine.
Selenomethionine was the predominant form of selenium in the dietary
supplement, therefore we evaluated the anti- tumorigenic effects of
selenomethionine. We found that selenomethionine inhibited tumor growth
(both in A549 lung and HT29 colon cancer cells) in a dose-dependent manner.
At 24 and 72 h, polyamine content of A549 and HT29 cancer cell lines was
decreased at doses that inhibited 50% of normal growth. Selenomethionine
treatment induced apoptosis in both cancer cell lines. Exogenous spermine
administration, which replenishes intracellular polyamine levels, prevented
selenomethionine induced apoptosis. Selenomethionine administration to the
cancer cell lines increased the number of cells in metaphase. This cell
cycle effect appeared to be reversed with the co-administration of
selenomethionine and spermine. These data suggested that at least part of
the anti- carcinogenic effects of selenium supplementation might be due to
a depletion in polyamine levels. This depletion of polyamines leads to an
induction in apoptosis and perturbations in the cell cycle.
相似文献
994.
L Gelberg MJ Robertson B Leake SL Wenzel L Bakhtiar EA Hardie N Sadler T Getzug 《Public health》2001,115(4):286-291
Findings are presented for a cross-sectional study of serological markers of hepatitis B virus (HBV) infection in an underserved population-impoverished veterans of the US armed forces in a Veterans Administration (VA) residential program in the US. We examine the demographic, background, and risk factors associated with HBV infection in this high-risk population. This paper presents a secondary analysis of cross-sectional survey and clinical data for 370 male veterans who were residents of a domiciliary care program for homeless veterans in Los Angeles, using chi(2), Fisher's Exact, and logistic regression analysis. About one-third (30.8%) of the sample tested positive for current or past HBV infection (ie, seropositive for either the HBV core antibody or surface antigen). After multivariate analysis, rates of HBV were significantly higher among veterans who were older, non-white, or who had a history of regular heroin use (a proxy measure for injection drug use), drug overdose, or drug detoxification treatment. The rate of current or past HBV infection among veterans in this sample (30.8%) was high compared to an estimated 5% to 8% of the general US population. Also, 3% of the sample were currently infected with HBV. Strategies for intervention include broader screening, immunization, and treatment interventions with this high-risk group. 相似文献
995.
996.
997.
J Gmez-Arbons MA Gallart A Mellado V Marco MJ Panads JM Maci 《European journal of haematology》1997,59(5):335-337
998.
999.
MJ King ; J Kosanke ; ME Reid ; J Poole ; J Banks ; NJ Hemming ; J Smythe ; PG Martin 《Transfusion》1997,37(10):1027-1034
BACKGROUND: Antigens of the human blood group system Gerbich (Ge) are located on sialoglycoproteins glycophorin C (GPC) and glycophorin D (GPD). CASE REPORT: The Ge+ proposita (RW) produced an alloanti-Ge after receiving 2 units of red cells (RBCs) during surgery. Further studies were carried out to characterize the antibody specificity, RBC GPC and/or GPD (GPC/GPD), and the glycophorin C gene (GYPC) from RW and her compatible siblings. RW's serum contained an alloanti-Ge that did not react with RBCs from RW or four of her siblings or with RBCs with Ge-negative phenotypes. An eluate of RW's antibody reacted weakly with GPC in Western blotting. RW's RBCs were positive with 20 alloanti-Ge2, 1 autoanti-Ge2, 4 alloanti-Ge3, and 1 alloanti-Ge4. Titrations revealed weak expression of these antigens on her RBCs and those of her compatible siblings as compared with controls. In contrast, titrations of mouse and rat monoclonal antibodies specific for GPC/GPD showed no differences. Western blotting of RBC membranes using GPC/GPD specific monoclonal antibodies showed a broad diffuse band corresponding to GPC.Ge in addition to GPC and GPD. Blotting of membranes from trypsin- treated RBCs from these individuals revealed an increase of 1500 in M(r) of membrane-bound tryptic fragment over that in the membranes from typsin-treated RBCs from persons with normal GPC/GPD. In RT-PCR, two products were obtained for RW and her compatible siblings: one had a complete deletion of exon 3 and the other had a base change (A–>T) in nucleotide 173 in exon 3 (confirmed by genomic DNA sequencing of exon 3). This point mutation has resulted in the loss of restriction enzyme Tth111 I-sensitive site in the mutant GYPC. CONCLUSION: The specificity of antibody in RW's serum was serologically anti-Ge2. Two genetic events occurred in exon 3 in GYPC of RW and her compatible siblings. The exon 3 deletion confirmed a Ge:-2,-3,4 haplotype. The abnormal tryptic fragment obtained was due to the (A173–>T) base change in exon 3 that resulted in Asp58–>Val in the deduced amino acid sequence at the membrane boundary. 相似文献
1000.
MJ Cumberbatch RG Hill RJ Hargreaves 《Cephalalgia : an international journal of headache》1998,18(10):659-663
In vivo electrophysiological assays in anesthetized rats have been used to compare the effects of the 5HT1B/1D receptor agonist, naratriptan, on central trigeminal nociceptive processing from dural and cutaneous inputs with its effects on nociceptive processing in the spinal cord. Naratriptan inhibited responses of single trigeminal neurons, to noxious electrical and mechanical stimulation of the dura and face, dose dependently by a maximum of 67±3% and 70±18%, respectively, at 3 mg kg−1 i.v. In contrast, naratriptan did not affect spinal dorsal horn neuronal responses to noxious mechanical stimulation of the hind-paw. These findings suggest that 5HT1B/1D receptors have differential effects on nociceptive processing in the trigeminal versus spinal dorsal horns and provide a potential explanation for the lack of general analgesic effects of brain penetrant 5HT1B/1D agonist antimigraine drugs. 相似文献