全文获取类型
收费全文 | 6951篇 |
免费 | 408篇 |
国内免费 | 99篇 |
专业分类
耳鼻咽喉 | 89篇 |
儿科学 | 106篇 |
妇产科学 | 130篇 |
基础医学 | 721篇 |
口腔科学 | 281篇 |
临床医学 | 577篇 |
内科学 | 2183篇 |
皮肤病学 | 85篇 |
神经病学 | 596篇 |
特种医学 | 248篇 |
外科学 | 1166篇 |
综合类 | 16篇 |
一般理论 | 1篇 |
预防医学 | 276篇 |
眼科学 | 68篇 |
药学 | 328篇 |
中国医学 | 6篇 |
肿瘤学 | 581篇 |
出版年
2024年 | 14篇 |
2023年 | 136篇 |
2022年 | 260篇 |
2021年 | 473篇 |
2020年 | 275篇 |
2019年 | 310篇 |
2018年 | 347篇 |
2017年 | 242篇 |
2016年 | 285篇 |
2015年 | 297篇 |
2014年 | 388篇 |
2013年 | 426篇 |
2012年 | 612篇 |
2011年 | 529篇 |
2010年 | 298篇 |
2009年 | 290篇 |
2008年 | 395篇 |
2007年 | 360篇 |
2006年 | 332篇 |
2005年 | 263篇 |
2004年 | 208篇 |
2003年 | 176篇 |
2002年 | 131篇 |
2001年 | 42篇 |
2000年 | 33篇 |
1999年 | 30篇 |
1998年 | 28篇 |
1997年 | 15篇 |
1996年 | 17篇 |
1995年 | 16篇 |
1994年 | 14篇 |
1992年 | 11篇 |
1991年 | 12篇 |
1990年 | 14篇 |
1989年 | 19篇 |
1988年 | 16篇 |
1987年 | 14篇 |
1986年 | 11篇 |
1985年 | 11篇 |
1979年 | 8篇 |
1978年 | 9篇 |
1977年 | 8篇 |
1976年 | 5篇 |
1974年 | 13篇 |
1973年 | 6篇 |
1972年 | 7篇 |
1971年 | 8篇 |
1970年 | 8篇 |
1969年 | 7篇 |
1966年 | 5篇 |
排序方式: 共有7458条查询结果,搜索用时 15 毫秒
81.
Matteo Morotti Christos E. Zois Rokaya El-Ansari Madeleine L. Craze Emad A. Rakha Shih-Jung Fan Alessandro Valli Syed Haider Deborah C. I. Goberdhan Andrew R. Green Adrian L. Harris 《British journal of cancer》2021,124(2):494
Background Glutamine (Gln) is an abundant nutrient used by cancer cells. Breast cancers cells and particularly triple-receptor negative breast cancer (TNBC) are reported to be dependent on Gln to produce the energy required for survival and proliferation. Despite intense research on the role of the intracellular Gln pathway, few reports have focussed on Gln transporters in breast cancer and TNBC.Methods The role and localisation of the Gln transporter SLC38A2/SNAT2 in response to Gln deprivation or pharmacological stresses was examined in a panel of breast cancer cell lines. Subsequently, the effect of SLC38A2 knockdown in Gln-sensitive cell lines was analysed. The prognostic value of SLC38A2 in a cohort of breast cancer was determined by immunohistochemistry.Results SLC38A2 was identified as a strongly expressed amino acid transporter in six breast cancer cell lines. We confirmed an autophagic route of degradation for SLC38A2. SLC38A2 knockdown decreased Gln consumption, inhibited cell growth, induced autophagy and led to ROS production in a subgroup of Gln-sensitive cell lines. High expression of SLC38A2 protein was associated with poor breast cancer specific survival in a large cohort of patients (p = 0.004), particularly in TNBC (p = 0.02).Conclusions These results position SLC38A2 as a selective target for inhibiting growth of Gln-dependent breast cancer cell lines.Subject terms: Breast cancer, Cancer metabolism 相似文献
82.
83.
84.
85.
86.
Paola Saccomandi Emiliano Schena Francesco Giurazza Riccardo Del Vescovo Michele A. Caponero Luca Mortato Francesco Panzera Roberto L. Cazzato Francesco R. Grasso Francesco M. Di Matteo Sergio Silvestri Bruno B. Zobel 《Lasers in medical science》2014,29(2):607-614
Tissue temperature distribution plays a crucial role in the outcome of laser-induced thermotherapy (LITT), a technique employed for neoplasias removal. Since recent studies proposed LITT for pancreatic tumors treatment, assessment of temperature and of its effects around the laser applicator could be useful to define optimal laser settings. The aims of this work are temperature monitoring and measurement of ablated tissue volume in an ex vivo porcine pancreas undergoing double-applicator LITT. A three-dimensional numerical model is implemented to predict temperature rise and volumes of ablated tissue in treated pancreas. Experiments are performed to validate the model, with two modalities: (1) 12-fiber Bragg grating sensors are adopted to monitor the heating and cooling during LITT at several distances from the applicators tip, and (2) 1.5-T MR imaging is used to estimate the ablated volume. Experimental data agree with theoretical ones: at 2 mm from both applicators tips, the maximum temperature increase is approximately 60 °C downward from the tips, while it increases of about 40 °C and 30 °C, respectively, at the level and upward from the tips. This behavior occurs also at other distances, proving that the tissue downward from the tip is mostly heated. Furthermore, the estimated volume with MRI agrees with theoretical one (i.d., 0.91?±?0.09 vs. 0.95 cm3). The encouraging results indicate that the model could be a suitable tool to choose the optimal laser settings, in order to control the volume of ablated tissue. 相似文献
87.
Mario Migliario Pamela Pittarella Matteo Fanuli Manuela Rizzi Filippo Renò 《Lasers in medical science》2014,29(4):1463-1467
Low-level laser therapy (LLLT) is widely used in regenerative medicine and in dental therapy by virtue of its beneficial effects in a plethora of pathological conditions. In this study, the effect of a 980 nm diode laser on pre-osteoblasts proliferation has been evaluated, along with reactive oxygen species (ROS) production. We hypothesized that ROS were a key factor in LLLT-induced pre-osteoblasts proliferation, as it is known that ROS can induce the activation of many biological pathways, leading to cell proliferation, differentiation or apoptosis. Murine pre-osteoblasts MC3T3 cells were irradiated with different energy outputs (1–50 J) in the absence or presence of the antioxidant N-Acetyl-L-cysteine (NAC). Laser treatment, in the absence of NAC, was able to induce a fluence-dependent statistically significant increase in ROS generation, while the presence of NAC strongly inhibited it. Cell proliferation, measured after laser stimulation, was significantly increased both at low and higher energy, with a peak at 10 J in the absence of the antioxidant. On the contrary, in the presence of NAC, laser irradiation was not able to induce any cell proliferation, suggesting a crucial role of ROS in this laser-induced cell effect. These results suggest that LLLT may be a useful tool for bone regeneration therapy and an effective range of fluences to be used is indicated. 相似文献
88.
89.
90.
Nicola Clementi Elena Criscuolo Matteo Castelli Nicasio Mancini Massimo Clementi Roberto Burioni 《Viruses》2012,4(11):3090-3108
The emergence of new influenza strains causing pandemics represents a serious threat to human health. From 1918, four influenza pandemics occurred, caused by H1N1, H2N2 and H3N2 subtypes. Moreover, in 1997 a novel influenza avian strain belonging to the H5N1 subtype infected humans. Nowadays, even if its transmission is still circumscribed to avian species, the capability of the virus to infect humans directly from avian reservoirs can result in fatalities. Moreover, the risk that this or novel avian strains could adapt to inter-human transmission, the development of resistance to anti-viral drugs and the lack of an effective prevention are all incumbent problems for the world population. In this scenario, the identification of broadly neutralizing monoclonal antibodies (mAbs) directed against conserved regions shared among influenza isolates has raised hopes for the development of monoclonal antibody-based immunotherapy and “universal” anti-influenza vaccines. 相似文献