全文获取类型
收费全文 | 1957篇 |
免费 | 122篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 106篇 |
妇产科学 | 22篇 |
基础医学 | 234篇 |
口腔科学 | 71篇 |
临床医学 | 175篇 |
内科学 | 453篇 |
皮肤病学 | 44篇 |
神经病学 | 158篇 |
特种医学 | 190篇 |
外科学 | 222篇 |
综合类 | 40篇 |
预防医学 | 122篇 |
眼科学 | 27篇 |
药学 | 124篇 |
中国医学 | 43篇 |
肿瘤学 | 57篇 |
出版年
2023年 | 11篇 |
2022年 | 13篇 |
2021年 | 40篇 |
2020年 | 32篇 |
2019年 | 40篇 |
2018年 | 38篇 |
2017年 | 42篇 |
2016年 | 31篇 |
2015年 | 52篇 |
2014年 | 72篇 |
2013年 | 75篇 |
2012年 | 80篇 |
2011年 | 95篇 |
2010年 | 82篇 |
2009年 | 73篇 |
2008年 | 69篇 |
2007年 | 88篇 |
2006年 | 63篇 |
2005年 | 77篇 |
2004年 | 53篇 |
2003年 | 72篇 |
2002年 | 65篇 |
2001年 | 56篇 |
2000年 | 66篇 |
1999年 | 52篇 |
1998年 | 50篇 |
1997年 | 40篇 |
1996年 | 42篇 |
1995年 | 30篇 |
1994年 | 41篇 |
1993年 | 34篇 |
1992年 | 38篇 |
1991年 | 37篇 |
1990年 | 24篇 |
1989年 | 28篇 |
1988年 | 36篇 |
1987年 | 31篇 |
1986年 | 19篇 |
1985年 | 23篇 |
1983年 | 15篇 |
1982年 | 15篇 |
1981年 | 11篇 |
1980年 | 16篇 |
1978年 | 9篇 |
1977年 | 16篇 |
1976年 | 15篇 |
1975年 | 11篇 |
1972年 | 11篇 |
1970年 | 8篇 |
1968年 | 8篇 |
排序方式: 共有2102条查询结果,搜索用时 15 毫秒
51.
Clemente G Pérez-Lázaro JJ Tejedor M Planas R De la Mata M Córdoba J Jara P Herrero JI Prieto M Suáreza G Arroyo V 《Gastroenterologia y hepatologia》2008,31(7):427-432
The Spanish Association for the Study of the Liver decided in 2006 to develop a project to assess the quality of the professionals, processes and medical units dealing with the management of patients with liver diseases in Spain. The current article reports the criteria proposed to assess the quality and the accreditation of the processes in hepatology. The processes considered include most patients with liver diseases and the accreditation system designed is highly specific. This document, together with a previous one published in gastroenterología y hepatología concerning the accreditation of the professionals and a third document dealing with the accreditation of liver units that will be published soon, form the basis of the quality assessment of hepatology in our country. 相似文献
52.
Rashid Khan Ashwani K Singal Bhupinderjit S Anand 《World journal of gastroenterology : WJG》2014,20(34):11935-11938
Alcohol abuse and chronic hepatitis C virus(HCV)infection are two major causes of chronic liver disease in the United States.About 10%-15%of liver transplants performed in the United States are for patients with cirrhosis due to combined alcohol and HCV infection.Data on outcomes on graft and patient survival,HCV recurrence,and relapse of alcohol use comparing transplants in hepatitis C positive drinkers compared to alcohol abuse or hepatitis C alone are conflicting in the literature.Some studies report a slightly better overall outcome in patients who were transplanted for alcoholic cirrhosis vs those transplanted for HCV alone or for combined HCV and alcohol related cirrhosis.However,some other studies do not support these observations.However,most studies are limited to a retrospective design or small sample size.Larger prospective multicenter studies are needed to better define the outcomes in hepatitis C drinkers. 相似文献
53.
54.
Hermine A van Duyvenvoorde Julian C Lui Sarina G Kant Wilma Oostdijk Antoinet CJ Gijsbers Mari?tte JV Hoffer Marcel Karperien Marie JE Walenkamp Cees Noordam Paul G Voorhoeve Verónica Mericq Alberto M Pereira Hedi L Claahsen-van de Grinten Sandy A van Gool Martijn H Breuning Monique Losekoot Jeffrey Baron Claudia AL Ruivenkamp Jan M Wit 《European journal of human genetics : EJHG》2014,22(5):602-609
Height is a highly heritable and classic polygenic trait. Recent genome-wide association studies (GWAS) have revealed that at least 180 genetic variants influence adult height. However, these variants explain only about 10% of the phenotypic variation in height. Genetic analysis of short individuals can lead to the discovery of novel rare gene defects with a large effect on growth. In an effort to identify novel genes associated with short stature, genome-wide analysis for copy number variants (CNVs), using single-nucleotide polymorphism arrays, in 162 patients (149 families) with short stature was performed. Segregation analysis was performed if possible, and genes in CNVs were compared with information from GWAS, gene expression in rodents'' growth plates and published information. CNVs were detected in 40 families. In six families, a known cause of short stature was found (SHOX deletion or duplication, IGF1R deletion), in two combined with a de novo potentially pathogenic CNV. Thirty-three families had one or more potentially pathogenic CNVs (n=40). In 24 of these families, segregation analysis could be performed, identifying three de novo CNVs and nine CNVs segregating with short stature. Four were located near loci associated with height in GWAS (ADAMTS17, TULP4, PRKG2/BMP3 and PAPPA). Besides six CNVs known to be causative for short stature, 40 CNVs with possible pathogenicity were identified. Segregation studies and bioinformatics analysis suggested various potential candidate genes. 相似文献
55.
56.
Marques DN da Mata AD Silveira JM Marques JR Amaral JP Guilherme NF 《Clinical oral investigations》2012,16(1):155-163
The objective of this study is to compare salivary hydrogen peroxide (HP) release kinetics and potential toxicity of systemic
exposure of four different whitening products. A double-blind, randomized controlled trial was conducted in a Portuguese dental
faculty clinic. Two hundred forty volunteers were randomized to eight intervention groups. Participants were randomly assigned
to receive active or placebo applications of one of four different products: Opalescence 10% PF™ (OPL), Vivastyle? 10%™ (VS10%),
Vivadent Paint On Plus™ (PO+), and Trés White Supreme™ (TWS). Saliva collection was obtained by established methods at different
times. The HP salivary content was determined by a photometric method. Salivary HP variations, total amount of salivary HP,
and counts of subjects above the safe daily HP dose were the main outcome measures. All whitening systems significantly released
HP to the saliva when compared to placebo, and all showed different release kinetics. The adaptable tray system (TWS) presented
a risk increase of 37% [20–54%, 95% confidence interval] when compared to the other systems. The use of an adaptable tray
whitening system with higher concentration of HP increases the toxicity potential. 相似文献
57.
Maria das Gra?as WS Coriolano Luciana R Belo Danielle Carneiro Amdore G Asano Paulo José AL Oliveira Douglas Monteiro da Silva Otávio G Lins 《Dysphagia》2012,27(4):550-555
Our goal was to study deglutition of Parkinson??s disease (PD) patients and normal controls (NC) using surface electromyography (sEMG). The study included 15 patients with idiopathic PD and 15 age-matched normal controls. Surface electromyography was collected over the suprahyoid muscle group. Conditions were the following: swallow at once 10 and 20?ml of water and 5 and 10?ml of yogurt of firm consistency, and freely drink 100?ml of water. During swallowing, durations of sEMG were significantly longer in PD patients than in normal controls but no significant differences of amplitudes were found. Eighty percent of the PD patients and 20?% of the NC needed more than one swallow to consume 20?ml of water, while 70?% of the PD patients and none of the NC needed more than one swallow to consume 5?ml of yogurt. PD patients took significantly more time and needed significantly more swallows to drink 100?ml of water than normal controls. We conclude that sEMG might be a simple and useful tool to study and monitor deglutition in PD patients. 相似文献
58.
59.
GEMMA PELARGONIO MARIA L. NARDUCCI ELEONORA RUSSO MICHELA CASELLA PASQUALE SANTANGELI ROBERT CANBY AMIN AL‐AHMAD LARRY D. PRICE LUIGI DI BIASE CANDICE J. KWARK MARK HARWOOD FRANCESCO PERNA GIANLUIGI BENCARDINO CAROLINA IERARDI ENRICO M. TRECARICHI ENRICA SANTELLI MARIO TUMBARELLO PRASANT MOHANTY SHANE BAILEY JOHN DAVID BURKHARDT FULVIO BELLOCCI ANDREA NATALE ANTONIO DELLO RUSSO 《Journal of cardiovascular electrophysiology》2012,23(10):1103-1108
Transvenous Lead Extraction . Introduction: As the population ages, the number of elderly patients with implantable cardiac devices referred for transvenous lead extraction will dramatically increase in Western countries. The safety and effectiveness of lead extraction in elderly patients has not been well evaluated. We report the safety and effectiveness of transvenous lead extraction in octogenarians. Methods and Results: From January 2005 to January 2011, we reviewed data from consecutive patients ≥ 80 years referred to our institutions for transvenous lead extraction because of cardiac device infection or lead malfunction. Clinical characteristics, procedural features, and periprocedural major and minor complications were compared between octogenarians and younger patients. Out of 849 patients undergoing lead extraction in the participating institutions during the study period, 150 (18%) patients were octogenarians (mean age 84 years; range 80–96; 64% males). A significantly higher percentage of octogenarians presented with chronic renal failure (55% vs 26%; P < 0.001), history of malignancy (22% vs 6%; P < 0.001), and chronic obstructive pulmonary disease (46% vs 19%; P < 0.001). Complete lead extraction rates were similar in the 2 age groups (97% in octogenarians vs 96% in patients <80 years; P = 0.39). Periprocedural death occurred in 2 (1.3%) patients ≥80 years and in 5 (0.72%) patients <80 years (P = 0.45 for comparison). No differences in terms of other periprocedural major and minor complications were found between the 2 age groups. Conclusion: Despite presenting with a significantly higher rate of comorbidities, transvenous lead extraction can be performed safely and successfully in octogenarians. (J Cardiovasc Electrophysiol, Vol. 23 pp. 1103‐1108, October 2012) 相似文献
60.
Carlos Gutirrez-Ulloa Cornelia E. Pea-Gonzlez Andrea Barrios-Gumiel Rafael Cea-Díez M. Jesús Serramía-Lobera M. ngeles Muoz-Fernndez F. Javier de la Mata Javier Snchez-Nieves Rafael Gmez 《RSC advances》2020,10(34):20083
The anionic carbosilane (CBS) dendrimer with sulfonate groups G2-S16 is a promising compound for the preparation of a microbicide gel to prevent HIV infection. However, until now its synthesis required aggressive conditions. Hence, a reliable synthetic procedure is very important to face GMP conditions and clinical trials. In this study, G2-S16 has been prepared by a new approach that involves the addition of an amine-terminated dendrimer to ethenesulfonyl fluoride (C2H3SO3F, ESF) and then transformation to the sulfonate dendrimer by treatment with a base. This strategy also makes feasible the synthesis of a labelled sulfonate dendrimer (G2-S16-FITC) to be used as a molecular probe for in vivo experiments. Interestingly, G2-S16-FITC enters into human peripheral blood mononuclear cells (PBMCs).Ethenesulfonyl fluoride (ESF) is a useful reagent to prepare sulfonate carbosilane dendrimers with antiviral properties and labelled dendrimers for biological studies. 相似文献