两种手术方式治疗耳郭假性囊肿效果比较

【目的】比较两种手术方式治疗耳郭假性囊肿的效果。【方法】选取2009年7月至2014年7月本科收治的69例耳郭假性囊肿患者,随机分为两组,其中观察组39例,用囊肿前壁切除及贯穿缝合碘仿加压法治疗;对照组30例,以传统的囊肿前壁切开引流、局部加压包扎法治疗。比较两组患者的手术疗效、平均住院天数以及医疗费用。【结果】两组患者术后随访6个月,观察组有效率100％,观察组有效率76．67％;观察组平均住院日7．15 d ,观察组平均住院日13．30 d;观察组平均医疗费用4171．98元,观察组平均医疗费用5174．33元,两组比较差异均有统计学意义（ P ＜0．05）。【结论】囊肿前壁切除及贯穿缝合碘仿加压法是治疗耳郭假性囊肿的一种可靠方法,值得临床推广。     

耐碳青霉烯类药物的细菌种类分布及耐药特性分析

目的探讨三甲中医医院耐碳青霉烯类药物的细菌的种类分布及耐药性情况。方法回顾性分析从临床分类筛选出的74株耐碳青霉烯类药物的抗菌药物的细菌,着重分析其分布种类及耐药特点。结果脑病病区耐碳青霉烯类药物的细菌检出率最高,耐药细菌种类以铜绿假单胞菌为主。30株铜绿假单胞菌对10种抗菌药物的耐药率较低的为妥布霉素(20.0%)、阿米卡星(13.3%);26株耐碳青霉烯鲍曼不动杆菌均为泛耐药株,耐药率较低的为米诺环素(69.2%)、头孢哌酮/舒巴坦(55.6%);18株耐碳青霉烯肠杆菌科细菌均为泛耐药株,耐药率较低的为米诺环素(44.4%)、四环素(55.6%)。结论耐碳青霉烯铜绿假单胞菌对氨基糖苷类抗菌药物较为敏感,但临床使用时要注意观察耐药性的变化;耐碳青霉烯鲍曼不动杆菌治疗建议临床上采用头孢哌酮/舒巴坦与米诺环素联合用药;对碳青霉烯类耐药的肠杆菌科细菌体外对四环素类药物有效,然而其体内效果如何还有待进一步证实。耐碳青霉烯类药物的细菌的发生率越来越高,各医院应结合药敏结果,合理用药,以减轻菌株耐药性的发生速度。     

自拟中药方浴足治疗老年闭塞性下肢动脉硬化症

【目的】探讨中药浴足治疗闭塞性下肢动脉硬化症的临床疗效。【方法】120例患者随机分为治疗组和对照组,对照组给予丁咯地尔10mg,每日一次静滴,治疗组在此基础上加用自拟中药方煎煮浴足,每日一次,于治疗前后,第1、2周末对足疼痛发作频次、持续时间、疼痛程度和踝肱指数（ABI）进行测评。【结果】加用中药浴足组在减少足静息痛发作频次、缩短每次发作持续时间、减轻疼痛程度、改善ABI及降低复发方面,均明显优于单用丁咯地尔组。【结论】中药浴足加丁咯地尔治疗闭塞性下肢动脉硬化症有较好疗效。     

Complete surgical resection of a 40-cm leiomyosarcoma of the large bowel mesentery

INTRODUCTION: Leiomyosarcoma of the large bowel mesentery is a rare entity and characteristically behaves in an aggressive fashion. Surgical resection is the mainstay of treatment and offers both symptomatic and therapeutic benefit. CASE: We describe the case of a 55-year-old woman who presented with weight loss, increasing abdominal girth and a large solid inhomogenous mass within the abdomen and pelvis demonstrated on a computed tomography (CT) scan. The patient underwent an exploratory laparotomy and extensive tumor debulking procedure with complete resection of her tumor. Final pathology revealed leiomyosarcoma of the large bowel mesentery. The patient has chosen not to receive adjuvant therapy. CONCLUSIONS: Leiomyosarcoma of the large bowel mesentery often presents as an advanced lesion making surgical resection a challenging and potentially morbid procedure. Although surgical resection may be faced with significant morbidity, maximum surgical effort with complete resection offers the best overall outcome for patients with this disease.     

HPLC-ELSD法测定黄芪注射液浓缩液微乳中黄芪甲苷含量

目的:建立黄芪注射液浓缩液微乳中黄芪甲苷的含量测定方法。方法:采用(HPLC-ELSD)。色谱柱:Zorbax C18柱(4.6 mm×250 mm,5μm);流动相:乙腈∶水(36∶70);检测波长:206nm;灵敏度为0.08 AUFS,流速:1.0 ml/min;柱温:25℃。ELSD参数:漂移管温度为55℃,空气气压280 kPa。结果:黄芪甲苷在0.004 145 6~0.040 456 0 mg/ml时有良好的线性关系(r=0.999 1),平均回收率为96.53%,RSD为0.76%。结论:HPLC-ELSD法具有准确、简便、灵敏度高、无干扰而且重现性好的优点,适合用于黄芪注射液微乳中黄芪甲苷含量的测定。     

Trends in pemphigus research over 15 years

Background Although pemphigus is a rare autoimmune blistering disease, it attracts the attention of physicians of many disciplines. Objective This study aims to assess the number of articles on pemphigus that have been published over 15 years in dermatology vs. non‐dermatology medical journals, and to evaluate the quality of available evidence. Methods PubMed was searched for articles on pemphigus published between 1 January 1993 to 31 December 2007 using the search word pemphigus. Articles were characterized by publication type and journal type per year. Regression analysis was used to determine the effect of year of publication on number of publications of each type. Results The search yielded 2032 publications on pemphigus during the evaluation period. Sixty‐one per cent were published in dermatology journals. Overall, the number of publications increased linearly with time. Most of this increase was accounted for by publications in non‐dermatology journals. There was an increase in clinical trials over the course of the study period. The number of certain publications with lower quality of evidence, mainly case reports and letters to the editor, increased significantly in the last few years. There was no increase in publications with high quality of evidence. Conclusions The increase on data from non‐dermatology disciplines is a welcome contribution. Nevertheless, high‐quality evidence on pemphigus is still lacking. We trust that the current trend towards evidence‐based dermatology will impact future research on this severe disease.