全文获取类型
收费全文 | 7399篇 |
免费 | 387篇 |
国内免费 | 46篇 |
专业分类
耳鼻咽喉 | 60篇 |
儿科学 | 202篇 |
妇产科学 | 69篇 |
基础医学 | 920篇 |
口腔科学 | 156篇 |
临床医学 | 423篇 |
内科学 | 2247篇 |
皮肤病学 | 66篇 |
神经病学 | 527篇 |
特种医学 | 298篇 |
外科学 | 1181篇 |
综合类 | 20篇 |
预防医学 | 179篇 |
眼科学 | 110篇 |
药学 | 534篇 |
中国医学 | 9篇 |
肿瘤学 | 831篇 |
出版年
2024年 | 6篇 |
2023年 | 60篇 |
2022年 | 126篇 |
2021年 | 182篇 |
2020年 | 106篇 |
2019年 | 139篇 |
2018年 | 173篇 |
2017年 | 150篇 |
2016年 | 167篇 |
2015年 | 200篇 |
2014年 | 215篇 |
2013年 | 298篇 |
2012年 | 466篇 |
2011年 | 562篇 |
2010年 | 323篇 |
2009年 | 286篇 |
2008年 | 476篇 |
2007年 | 524篇 |
2006年 | 510篇 |
2005年 | 478篇 |
2004年 | 501篇 |
2003年 | 505篇 |
2002年 | 446篇 |
2001年 | 75篇 |
2000年 | 51篇 |
1999年 | 69篇 |
1998年 | 92篇 |
1997年 | 88篇 |
1996年 | 55篇 |
1995年 | 57篇 |
1994年 | 43篇 |
1993年 | 56篇 |
1992年 | 35篇 |
1991年 | 28篇 |
1990年 | 41篇 |
1989年 | 28篇 |
1988年 | 30篇 |
1987年 | 19篇 |
1986年 | 17篇 |
1985年 | 26篇 |
1984年 | 13篇 |
1983年 | 16篇 |
1982年 | 15篇 |
1981年 | 12篇 |
1980年 | 14篇 |
1979年 | 7篇 |
1978年 | 12篇 |
1974年 | 5篇 |
1972年 | 3篇 |
1971年 | 3篇 |
排序方式: 共有7832条查询结果,搜索用时 46 毫秒
101.
Primary cutaneous localized/clearly-outlined true histiocytic sarcoma: Two long-term follow-up cases
Naoko Sato Eiichi Arai Yasuhiro Nakamura Yasuo Yazawa Masanori Yasuda 《The Journal of dermatology》2020,47(6):651-653
Histiocytic sarcoma (HS) is a rare hematopoietic tumor that mainly involves extranodal sites, including the intestinal tract, skin, soft tissues and other organs. It is well known as an aggressive neoplasm that shows a poor response to therapy. However, a subset of patients with resectable disease has shown a favorable outcome with surgical treatment. Primary cutaneous HS is exceedingly rare and, to date, its long-term prognosis has thus not been well described. Here, we highlight two cases of primary cutaneous HS that showed long-term survival. Case 1 was a healthy 47-year-old woman who found a 12-mm tumor on her forehead. Case 2 was a 66-year-old woman, under follow up of a myxoid liposarcoma in her leg, who presented with a 25-mm tumor in her hypothenar eminence. Histologically, the tumors in both cases had a smooth outline with proliferating atypical tumor cells that showed histiocytic differentiation as revealed by immunohistochemistry with antibodies to CD68 (KP-1) and lysozyme in case 1; and CD68, lysozyme and CD163 in case 2. Tumor cells in case 1 had a monotonous appearance. After complete resection, cases 1 and 2 have survived for 10 and 4 years, respectively, without recurrence. To date, such patients are relatively long follow-up cases of survival from HS and highlight how a clear outline of the primary cutaneous HS tumor may be associated with its resectability and be an important factor in the assessment of its curability. 相似文献
102.
Periodontal disease and pneumonia mortality in haemodialysis patients: A 7‐year cohort study 下载免费PDF全文
Masanori Iwasaki George W. Taylor Shuji Awano Akihiro Yoshida Shota Kataoka Toshihiro Ansai Hidetoshi Nakamura 《Journal of clinical periodontology》2018,45(1):38-45
Aim
To evaluate the association between periodontal disease and pneumonia mortality in haemodialysis patients.Materials and Methods
This prospective cohort study included 211 patients (mean age, 64.4 years) undergoing haemodialysis at a single medical centre. The patients underwent a baseline clinical dental examination in 2008 and were then followed up until July 2015. Periodontal disease was defined as the presence of clinical attachment loss of ≥4 mm in ≥30% of the probed sites. The primary endpoint, that is death from pneumonia, was determined by reviewing death certificates and was analysed using the competing‐risks regression model.Results
At baseline, 92 patients (43.6%) had periodontal disease. The median follow‐up period was 84 months (interquartile range, 36–86 months). Of the 68 deaths that occurred, 21 were from pneumonia. The multivariable competing‐risks regression model showed that periodontal disease was significantly associated with death from pneumonia (adjusted subhazard ratio, 3.49; 95% confidence interval, 1.14–10.64), after adjusting for other baseline health characteristics.Conclusions
The results of this study suggest that periodontal disease is independently associated with pneumonia mortality in haemodialysis patients. Future studies evaluating the potential effect of oral interventions for periodontal health improvement on pneumonia in haemodialysis patients would be of great interest. 相似文献103.
104.
Masayuki Kaga Shinichi Kakuda Yusuke Ida Hirokazu Toshima Masanori Hashimoto Kazuhiko Endo Hidehiko Sano 《European journal of oral sciences》2014,122(1):78-83
The buffering capacity and inhibitory effects on enamel demineralization of two commercially available dental sealants were evaluated in this study. The effects of filler particles were also examined. Disks of enamel and cured sealant materials of BeautiSealant (silica or S‐PRG filler) or Teethmate F‐1 were incubated in lactic acid solutions (pH 4.0) for 1–6 d. The pH changes and amounts of ions released in the solutions were assessed, and enamel surfaces were observed using a scanning electron microscope. The pH of the solution with BeautiSealant (S‐PRG filler) was neutralized from pH 4.0 to pH 6.1 (after incubation for 1 d) and from pH 4.0 to pH 6.7 (after incubation for 6 d). In addition, no release of calcium ions was detected and the enamel surface was morphologically intact in scanning electron microscopy images. However, the pH of the solution with Teethmate F‐1 remained below pH 4.0 during incubation from days 1 to 6. Calcium release was increased in solutions up to and after 6 d of incubation. Scanning electron microscopy images showed that the structures of hydroxyapatite rods were exposed at the specimen surfaces as a result of demineralization. Ions released from S‐PRG filler‐containing dental sealant rapidly buffered the lactic acid solution and inhibited enamel demineralization. 相似文献
105.
Incidence of gastric adenocarcinoma among lesions diagnosed as low‐grade adenoma/dysplasia on endoscopic biopsy: A multicenter,prospective, observational study 下载免费PDF全文
106.
107.
Masanori Hashimoto Shinichi Fujita Kazuhiko Endo Hiroki Ohno 《European journal of oral sciences》2009,117(5):611-617
The purpose of this study was to evaluate the durability of one-bottle self-etching adhesive during long-term water-storage testing. Resin–dentin bonded specimens were prepared using four commercially available one-bottle self-etching adhesives. The specimens were sectioned perpendicular to the adhesive interface to produce beam-shaped specimens that were stored in water for 24 h (control group) and 100, 200, and 300 d (experimental groups). After each storage period, the beams were subjected to a microtensile bond test. After the bond test, fractured surfaces were examined using a scanning electron microscope. In addition, interfacial observations of the silver tracer were performed using the secondary and back-scatter modes of the scanning electron microscope. The bond strength of all tested adhesives decreased significantly after 100 or more days in water. The interfacial observations showed an oxygen-inhibition zone as electron lucent in the adhesive–composite border in control specimens, displaying silver impregnation with breakage after aging. The deterioration of the oxygen-inhibition zone in the adhesive–resin composite junction resulted in a decrease in bond strength after 100 d in water for one-bottle self-etching adhesives. 相似文献
108.
Hiyama T Tanaka S Yoshihara M Sasao S Kose K Shima H Tuncel H Ueno Y Ito M Kitadai Y Yasui W Haruma K Chayama K 《Journal of gastroenterology and hepatology》2004,19(7):756-760
BACKGROUND: Gastric cancer can progress through two pathways of genomic instability: chromosomal (CIN) and microsatellite instability (MSI). It is hypothesized that these two pathways are not always independent and that some tumors show overlap between these two mechanisms. METHODS: A total of 98 sporadic gastric cancers were classified based on their MSI status, using microsatellite assay with BAT26. Evidence for CIN was investigated by identifying loss of heterozygosity (LOH) events on chromosome arms, 5q, 10p, 17p, 17q, and 18q, which are regions harboring tumor suppressor genes that are significant in gastric cancer development. RESULTS: Twelve tumors (12%) showed high-frequency MSI (MSI-H). Overall, 43 of the tumors (44%) had at least one LOH event, with most frequent chromosomal losses observed on 10p and 18q (30%, respectively), followed by 5q (21%), 17p (14%), and 17q (12%). Interestingly, overlap was observed between CIN and MSI pathways. Of 43 cancers with LOH events, four (9%) were also MSI-H. It was also found that 48% of cancers without MSI-H had no LOH events identified, comprising a subgroup of tumors that were not representative of either of these two pathways of genomic instability. CONCLUSION: These results suggest that molecular mechanisms of genomic instability are not necessarily independent and may not be fully defined by either the MSI or CIN pathways in sporadic gastric cancers. 相似文献
109.
110.
Fumiki?Yoshihara Miki?Imazu Toshimitsu?Hamasaki Toshihisa?Anzai Satoshi?Yasuda Shin?Ito Haruko?Yamamoto Kazuhiko?Hashimura Yoshio?Yasumura Kiyoshi?Mori Masataka?Watanabe Masanori?Asakura Masafumi?Kitakaze 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2018,32(2):183-190