全文获取类型
收费全文 | 473篇 |
免费 | 20篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 19篇 |
妇产科学 | 6篇 |
基础医学 | 25篇 |
口腔科学 | 15篇 |
临床医学 | 33篇 |
内科学 | 84篇 |
皮肤病学 | 2篇 |
神经病学 | 20篇 |
特种医学 | 158篇 |
外科学 | 52篇 |
综合类 | 19篇 |
预防医学 | 22篇 |
眼科学 | 2篇 |
药学 | 12篇 |
肿瘤学 | 25篇 |
出版年
2021年 | 4篇 |
2020年 | 5篇 |
2019年 | 3篇 |
2018年 | 9篇 |
2017年 | 8篇 |
2016年 | 8篇 |
2015年 | 15篇 |
2014年 | 8篇 |
2013年 | 19篇 |
2012年 | 17篇 |
2011年 | 4篇 |
2010年 | 17篇 |
2009年 | 13篇 |
2008年 | 17篇 |
2007年 | 14篇 |
2006年 | 12篇 |
2005年 | 8篇 |
2004年 | 13篇 |
2003年 | 11篇 |
2002年 | 10篇 |
2001年 | 11篇 |
2000年 | 9篇 |
1999年 | 9篇 |
1998年 | 20篇 |
1997年 | 22篇 |
1996年 | 17篇 |
1995年 | 12篇 |
1994年 | 17篇 |
1993年 | 9篇 |
1992年 | 4篇 |
1991年 | 14篇 |
1990年 | 10篇 |
1989年 | 14篇 |
1988年 | 7篇 |
1987年 | 5篇 |
1986年 | 11篇 |
1985年 | 11篇 |
1984年 | 10篇 |
1983年 | 3篇 |
1982年 | 3篇 |
1981年 | 6篇 |
1980年 | 10篇 |
1979年 | 11篇 |
1978年 | 11篇 |
1977年 | 7篇 |
1976年 | 3篇 |
1975年 | 4篇 |
1958年 | 2篇 |
1954年 | 2篇 |
1953年 | 2篇 |
排序方式: 共有497条查询结果,搜索用时 15 毫秒
71.
Computerized tomographic scan and gunshot wounds of the head: indications and radiographic findings. 总被引:2,自引:0,他引:2
The authors document their experience with the computerized tomographic (CT) scanner for evaluating gunshot wounds of the head. Only those patients who were considered to be operative candidates and who were neurologically stable were scanned. In the postoperative period, patients who were not scanned preoperatively and those whose condition did not improve were also scanned. In the preoperative period the CT scanner is useful for identifying and localizing missile tracks, bony and metallic fragments, intra- and extraparenchymal hematomas, intracranial air, and brain swelling. In the postoperative period the CT scanner may demonstrate retained bone fragments, edema, brain abscess, and intracranial air. The limitations of the CT scan in evaluating gunshot wounds include an inability to define vascular lesions suchas traumatic aneurysms and post-traumatic spasm. Metallic scatter from missile fragments may render certain CT cuts uninterpretable. In addition, the CT scan may appear minimally abnormal in spite of immediate and irreversible injury caused by a shock wave transmitted to brain stem structures. The CT scanner has superceded angiography as a diagnostic tool for evaluating gunshot wounds of the head because it is noninvasive and rapid, allows visualization of the entire head, can resolve very small lesions that produce little or no mass effect, can help to determine the nature of intracranial lesions and may quantitate the amount of hemorrhage and edema. Because it enables physicians to visualize intracranial structures in three dimensions, the CT scan may precisely define missile tracks and contiguous lesions in a manner not heretofore possible with other diagnostic modalities. Thus, it is invaluable for the rational planning of surgical therapy. 相似文献
72.
73.
74.
75.
Gad A Laurino M Maravilla KR Matsushita M Raskind WH 《American journal of medical genetics. Part A》2008,(14):1880-1885
The Waardenburg syndromes (WS) account for approximately 2% of congenital sensorineural deafness. This heterogeneous group of diseases currently can be categorized into four major subtypes (WS types 1-4) on the basis of characteristic clinical features. Multiple genes have been implicated in WS, and mutations in some genes can cause more than one WS subtype. In addition to eye, hair, and skin pigmentary abnormalities, dystopia canthorum and broad nasal bridge are seen in WS type 1. Mutations in the PAX3 gene are responsible for the condition in the majority of these patients. In addition, mutations in PAX3 have been found in WS type 3 that is distinguished by musculoskeletal abnormalities, and in a family with a rare subtype of WS, craniofacial-deafness-hand syndrome (CDHS), characterized by dysmorphic facial features, hand abnormalities, and absent or hypoplastic nasal and wrist bones. Here we describe a woman who shares some, but not all features of WS type 3 and CDHS, and who also has abnormal cranial bones. All sinuses were hypoplastic, and the cochlea were small. No sequence alteration in PAX3 was found. These observations broaden the clinical range of WS and suggest there may be genetic heterogeneity even within the CDHS subtype. 相似文献
76.
Olivo-Diaz A Romero-Valdovinos M Gudiño-Ramirez A Reyes-Gordillo J Jimenez-Gonzalez DE Ramirez-Miranda ME Martinez-Flores WA Martinez-Hernandez F Flisser A Maravilla P 《Parasitology research》2012,111(1):487-491
The intestinal protozoan parasite Blastocystis is one of the most common parasites worldwide in humans and, although its ability to cause human disease has been questioned, some reports have demonstrated that this microorganism is associated to the development of irritable bowel syndrome (IBS) and to a proinflammatory response, in which the expression of some cytokines is unregulated. Since inflammatory cytokine gene polymorphisms might have a role in the pathophysiology of IBS, we assessed the role of single nucleotide polymorphisms (SNPs) for interleukin (IL)-8 and IL-10, in previously collected DNA samples from IBS patients and controls, with or without Blastocystis infection. IL-8+396(G) and IL-10-1082 (A) alleles (p=0.0437 and p=0.0267, respectively), as well as their homozygous (p<0.0001 and p=0.0039, respectively) and IL-8+781(CT) (p=0.0248) genotypes were significantly overrepresented in patients with IBS in comparison with controls. IL-8+396(GG) genotype was relevant because it was associated to IBS (p<0.0001), to Blastocystis (p=0.0025), and to IBS–Blastocystis (p=0.0272). In the latter binomial association, this genotype presented a high contribution (etiological fraction?=0.452) and a risk >fourfold to develop IBS. IL-8+781 (T) and IL-10-592 (C) alleles were also associated to Blastocystis and to IBS–Blastocystis, respectively (p=0.0448 and p=0.0166). Our results suggest that some IL-8 and IL-10 SNPs could change individual susceptibility increasing the relative risk in the development of IBS in Blastocystis carriers. 相似文献
77.
78.
A population genetics analysis in clinical isolates of Sporothrix schenckii based on calmodulin and calcium/calmodulin‐dependent kinase partial gene sequences
下载免费PDF全文
![点击此处可从《Mycoses》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Lucia Rangel‐Gamboa Fernando Martinez‐Hernandez Pablo Maravilla Ana Flisser 《Mycoses》2018,61(6):383-392
Sporotrichosis is a subcutaneous mycosis that is caused by diverse species of Sporothrix . High levels of genetic diversity in Sporothrix isolates have been reported, but few population genetics analyses have been documented. To analyse the genetic variability and population genetics relations of Sporothrix schenckii Mexican clinical isolates and to compare them with other reported isolates. We studied the partial sequences of calmodulin and calcium/calmodulin‐dependent kinase genes in 24 isolates; 22 from Mexico, one from Colombia, and one ATCC ®6331?; the latter was used as a positive control. In total, 24 isolates were analysed. Phylogenetic, haplotype and population genetic analyses were performed with 24 sequences obtained by us and 345 sequences obtained from GenBank. The frequency of S. schenckii sensu stricto was 81% in the 22 Mexican isolates, while the remaining 19% were Sporothrix globosa . Mexican S. schenckii sensu stricto had high genetic diversity and was related to isolates from South America. In contrast, S. globosa showed one haplotype related to isolates from Asia, Brazil, Spain and the USA . In S. schenckii sensu stricto, S. brasiliensis and S. globosa, haplotype polymorphism (θ) values were higher than the nucleotide diversity data (π). In addition, Tajima's D plus Fu and Li's tests analyses displayed negative values, suggesting directional selection and arguing against the model of neutral evolution in these populations. In addition, analyses showed that calcium/calmodulin‐dependent kinase was a suitable genetic marker to discriminate between common Sporothrix species. 相似文献
79.
80.
Miroslav ZME?KAL Eva KRáLíKOVá Ivana KURCOVá Pavel PAFKO Robert LISCHKE Libor FILA Lucie VALENTOVá BARTáKOVá Keely FRASER 《Slovenian Journal of Public Health》2016,55(1):29-35