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上斜肌前部前徙术治疗上斜肌麻痹的外旋斜的研究 总被引:1,自引:0,他引:1
目的 观察术中可调整缝线的上斜肌前部前徙术治疗上斜肌麻痹的外旋斜的效果。方法 对6例(9眼)外旋斜患者(其中双眼外旋斜和单眼外旋斜各3例)行此术式,在术前、术中、术后1周分别行双马多氏杆检查第一眼位的主观旋转斜。分析旋转斜度与手术量的关系及治疗效果。结果 6例患者术前都存在正前方及下方双眼复视症状,第一眼位的外旋斜5~15。,平均10.5。。术毕双马多氏杆检查第一眼位为0^o~内旋斜5^o,平均内旋斜3.7^o。术后所有患者正前方及向下看复视症状消失,术后1周为外旋2^o~内旋4^o,平均内旋1.4^o。其中2例患者术后7个月复诊,一例外旋斜3^o;另一例为旋转斜0^o,都未出现明显复视症状。结论 术中可调整缝线的上斜肌前部前徙术是一种安全可靠的矫正上斜肌麻痹的外旋斜的手术方式,常需要过矫至内旋5^o左右来代偿术后出现的回退。 相似文献
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Clinical Features and Surgical Treatment of A-pattern Exotropia 总被引:1,自引:0,他引:1
Jingchang Chen Guanghuan Mai Daming Deng Xiaoming Lin Yan Guo Xiao Yang Chunxiu YuanZhongshan Ophthalmic Center Sun Yan-san University Guangzhou China 《眼科学报》2004,20(3):163-167
IntroductionAnA鄄patternexotropiashowssignificantlymoreexodeviationindowngazeversusupgaze,inwhichthechangeofbinocularalignmentresemblesthealphaberA.Accordingtopublishedreports[1~4],A鄄patternexotropiaisviewedastheleasttypeofAandVpatterns.However,thepr鄄evalenceofA鄄patternexotropiaratherincreasedinourclinicalstudies[5],inwhichparticularattentionwaspaidtoobservethedeviationindownwardgazeandassesssuperiorobliquefunction.Accordingly,clinicalcharacteristics,surgicaltreatmentandtreatmentoutcome… 相似文献
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Leptin and asthma in overweight children at 12 years of age 总被引:1,自引:0,他引:1
Obesity is suggested as a risk factor for asthma, but the mechanisms are unclear. The relationship between obesity and asthma has not been considered in children born with very low-birth weight (VLBW). We hypothesized that overweight was a contributing factor for asthma in VLBW children, and that leptin and leptin-associated cytokines might play roles in overweight-related asthma. Seventy-four VLBW and 64 normal birth weight (NBW) children participated in a 12-yr follow up study assessing asthma and allergy. Twenty-seven (12 VLBW) of the 138 children were overweight according to the proposed international definition. The diagnosis of current asthma was made by a pediatrician. Serum levels of leptin and interferon (IFN)-gamma were analyzed by enzyme-linked immunosorbent assay (ELISA). Leptin levels were considerably higher in the overweight than in the non-overweight children (median value: 18.1 vs. 2.8 ng/ml, p < 0.001). In the overweight children, current asthmatics had twice as high levels of leptin as children without current asthma (median value: 30.8 vs. 14.3 ng/ml, p = 0.14), but this was not the case in the non-overweight children. IFN-gamma was more often detected in the overweight than in the non-overweight children (61% vs. 12%, p < 0.001), and there was a positive correlation between the levels of leptin and the levels of IFN-gamma (Rho = 0.40, p < 0.001). In the VLBW group, the overweight children had a significantly increased risk for current asthma compared with the non-overweight children after adjustment for the neonatal risk factors [adjusted odds ratio (OR) 5.8, 95% confidence interval (CI): 1.2-27]. Thus, overweight was associated with asthma in the VLBW children. Our hypothesis remained that leptin might be involved in the pathogenesis of asthma in the overweight children, and IFN-gamma might be a pathway in the process of leptin-induced inflammation. 相似文献
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葡萄糖酸依诺沙星溶液的稳定性研究 总被引:4,自引:0,他引:4
目的考察葡萄糖酸依诺沙星溶液的稳定性。方法采用紫外分光光度法测定溶液中葡萄糖酸依诺沙星含量,HPLC法测定有关物质含量,考察了不同pH值的葡萄糖酸依诺沙星溶液在光照及高温条件下的质量变化。结果葡萄糖酸依诺沙星溶液在光照下易变色pH值5.5~6.0溶液在高温、光照5d后即出现结晶。pH值3.0~4.0溶液在光照条件下含量下降较多,有关物质增加较多。pH在4.0~5.5之间的葡萄糖酸依诺沙星溶液稳定性较好。结论本品应遮光保存,液体制剂的pH值范围确定在4.0~5.5之间较好。 相似文献
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Qing-Yi Lu Yu-Sheng Jin Allan Pantuck Zuo-Feng Zhang David Heber Arie Belldegrun Mai Brooks Robert Figlin Jianyu Rao 《Clinical cancer research》2005,11(4):1675-1683
Alteration of actin polymerization and loss of actin filaments is a marker of cellular dedifferentiation and early malignant transformation. To study this phenomenon, an in vitro human urothelial model consisting of two cell lines, HUC-PC and MC-T11, were incorporated into the study design. These two cell lines have different malignant transformation potential. The effect of green tea extract (GTE), a potential anticancer agent, on actin remodeling was investigated. Upon exposure to the carcinogen 4-aminobiphenyl (4-ABP), the untransformed HUC-PC undergoes malignant transformation whereas the transformed MC-T11 progresses from noninvasive to invasive tumor. GTE induces actin polymerization in MC-T11 cells in a dose-responsive manner, but this effect is less obvious in the untransformed, more differentiated HUC-PC cells, which natively have higher actin polymerization status. In contrast, GTE antagonizes carcinogen 4-ABP induced actin depolymerization and stress fiber disruption in HUC-PC cells. In MC-T11 cells, GTE inhibits 4-ABP induced motility by increasing cell adhesion and focal adhesion complex formation. The effect of GTE on actin remodeling seems to be mediated by the stimulation of small GTP-binding protein Rho activity, because C3 exoenzyme, a specific inhibitor for Rho, blocks GTE-mediated Rho activation and stress fiber formation in MC-T11 cells. This study shows that GTE exerts an effect on cytoskeletal actin remodeling and provides further support for the use of GTE as a chemopreventive agent. 相似文献
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