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排序方式: 共有2633条查询结果,搜索用时 265 毫秒
991.
Antitumour necrosis factor‐α therapy for hidradenitis suppurativa: results from a national cohort study between 2000 and 2013
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992.
993.
994.
Circulating fibroblast growth factor‐23 plasma levels predict adverse cardiovascular outcomes in patients with diabetes mellitus with coronary artery disease
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![点击此处可从《Diabetes/metabolism research and reviews》网站下载免费的PDF全文](/ch/ext_images/free.gif)
José Tuñón Beatriz Fernández‐Fernández Rocío Carda Ana M. Pello Carmen Cristóbal Nieves Tarín Álvaro Aceña María Luisa González‐Casaus Ana Huelmos Joaquín Alonso Óscar Lorenzo Emilio González‐Parra Ignacio Hernández‐González Ignacio Mahíllo‐Fernández Lorenzo López‐Bescós Jesús Egido 《Diabetes/metabolism research and reviews》2016,32(7):685-693
995.
Characteristics of patients with plaque psoriasis who have discordance between Psoriasis Area Severity Index and dermatology life quality index scores
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996.
JH Trouvin MC Maubrey H. Raynal and C. Jacquot 《Fundamental & clinical pharmacology》1991,5(6):497-502
The time course of 5-hydroxytryptophan (5-HTP), serotonin (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in four rat brain areas (hypothalamus, hippocampus, striatum and olfactory bulbs) were investigated after treatment with L-dopa (125 mg/kg, ip) + benserazide (50 mg/kg, ip). 5-HTP levels increased as early as 0.5 h, showed maximum accumulation at 1.5 h and returned to control levels within 4 h, while 5-HT was markedly decreased in all four structures, with a maximum effect at 1.5 h (approximately -70%) in the four areas. The decrease in 5-HT was not accompanied by changes in 5-HIAA levels. In agreement with previous studies, these data demonstrate that L-dopa loading interferes with serotonin metabolism in the rat brain. However, in addition to the releasing action of newly-synthesized dopamine, the accumulation of 5-HTP and the parallel decrease in 5-HT indicate a reduction in 5-HT synthesis. This inhibition could be explained by a competitive effect of L-dopa for aromatic aminoacid decarboxylase activity. 相似文献
997.
The survival of red blood cells, which were strongly incompatible in vitro, was measured in five patients whose serum contained an antibody to a high-frequency antigen. In the two patients with anti-Cha, and in the patient with anti-Yka, the cells survived normally. In the patient with anti-Ge, a small proportion of the cells was destroyed at an increased rate during the first 24 hours, but the remaining cells survived normally. In the patient with anti-Vel, the injected cells were rapidly destroyed. 相似文献
998.
Blood/vessel wall cell interactions depend, in part, on the expression of adhesion receptors on cell surfaces, such as expression of the vitronectin receptor (VnR) on the apical surface of endothelial cells (ECs) for platelet/EC adhesion. However, it is unclear how receptor expression is regulated from within cells. In previous studies, we found that ECs metabolize linoleic acid into the lipoxygenase monohydroxide, 13-hydroxyoctadecadienoic acid (13-HODE), and that the intracellular level of 13-HODE correlates inversely with VnR expression and platelet adhesion to the EC apical surface. In this study, we determined the physical associations of 13-HODE and VnR in unstimulated and stimulated ECs, ie, at times when ECs were and were not adhesive for specific ligands and platelets, using double antibody immunofluorescent staining techniques and binding assays. 13-HODE and the VnR were colocalized within unstimulated ECs. When ECs were stimulated, 13-HODE was no longer detectable, either in or outside the ECs, and the VnR was detected on the apical surface of the ECs. These changes were paralleled by increased vitronectin binding and increased platelet adhesion to the ECs. We suggest that colocalization of 13-HODE with VnR reflects a 13-HODE/VnR interaction, confining the VnR in a nonadhesive form inside unstimulated ECs, and, as a result, the ECs are nonadhesive. When the ECs are stimulated, 13-HODE and VnR dissociate, allowing the VnR to relocate on the EC surface, where the VnR undergoes a conformational change resulting in increased EC adhesivity. 相似文献
999.
1000.
Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women 总被引:11,自引:2,他引:9
Taboulet J; Frenkian M; Frendo JL; Feingold N; Jullienne A; de Vernejoul MC 《Human molecular genetics》1998,7(13):2129-2133
High bone resorption by the osteoclast results in osteoporosis, a disease
affecting 40% of women after the menopause. Calcitonin, used to treat
osteoporosis, inhibits bone resorption via receptors located on the
osteoclasts. Two alleles of the calcitonin receptor gene ( CTR ) exist: a
base mutation T-->C in the third intracellular C-terminal domain changes
a proline (CCG) at position 447 to a leucine (CTG). We therefore studied
the distribution of these alleles in a cohort of 215 post-menopausal
Caucasian women suffering or not from osteoporotic fractures. The region of
interest within the point mutation was amplified by PCR and screened for
single strand conformation polymorphism. This work was followed by DNA
sequencing of the fragments amplified. We found that bone mineral density
(BMD) at the femoral neck was significantly higher in heterozygous subjects
with the Rr genotype compared with the homozygous leucine (RR) and
homozygous proline (rr) genotypes. Also, a decreased fracture risk was
observed in heterozygote subjects. In conclusion, our results suggest that
polymorphism of CTR could be associated with osteoporotic fractures and BMD
in a population of post-menopausal women. CTR heterozygotes could produce
both alleles of the receptor. The heterozygous advantage effect of Rr
subjects could explain their protection against osteoporosis: higher bone
density and decreased fracture risk. Establishing the genotype of the CTR
gene in post-menopausal women could be of value in evaluating their risk of
developing fractures.
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