全文获取类型
收费全文 | 1085篇 |
免费 | 60篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 26篇 |
儿科学 | 13篇 |
妇产科学 | 40篇 |
基础医学 | 143篇 |
口腔科学 | 51篇 |
临床医学 | 91篇 |
内科学 | 360篇 |
皮肤病学 | 10篇 |
神经病学 | 54篇 |
特种医学 | 22篇 |
外科学 | 117篇 |
综合类 | 6篇 |
一般理论 | 1篇 |
预防医学 | 61篇 |
眼科学 | 9篇 |
药学 | 65篇 |
肿瘤学 | 83篇 |
出版年
2023年 | 8篇 |
2022年 | 36篇 |
2021年 | 71篇 |
2020年 | 27篇 |
2019年 | 29篇 |
2018年 | 41篇 |
2017年 | 40篇 |
2016年 | 25篇 |
2015年 | 42篇 |
2014年 | 53篇 |
2013年 | 46篇 |
2012年 | 92篇 |
2011年 | 92篇 |
2010年 | 44篇 |
2009年 | 45篇 |
2008年 | 67篇 |
2007年 | 71篇 |
2006年 | 55篇 |
2005年 | 53篇 |
2004年 | 42篇 |
2003年 | 29篇 |
2002年 | 18篇 |
2001年 | 7篇 |
2000年 | 7篇 |
1999年 | 6篇 |
1994年 | 3篇 |
1993年 | 2篇 |
1992年 | 6篇 |
1991年 | 3篇 |
1990年 | 6篇 |
1989年 | 6篇 |
1988年 | 10篇 |
1987年 | 2篇 |
1986年 | 6篇 |
1985年 | 7篇 |
1984年 | 3篇 |
1983年 | 3篇 |
1981年 | 2篇 |
1979年 | 5篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1974年 | 4篇 |
1973年 | 5篇 |
1970年 | 8篇 |
1969年 | 2篇 |
1968年 | 3篇 |
1966年 | 2篇 |
1964年 | 1篇 |
1963年 | 1篇 |
排序方式: 共有1152条查询结果,搜索用时 15 毫秒
981.
Clinical outcomes for patients presenting with N3 head and neck squamous cell carcinoma: Analysis of the National Cancer Database 下载免费PDF全文
982.
Gregg S. Tracton Lukasz M. Mazur Prithima Mosaly Lawrence B. Marks Shiva Das 《Practical radiation oncology》2018,8(6):458-467
Purpose
The aim of this study is to propose a set of innovative principles for the effective design of electronic checklists to enhance safety mindfulness (a specific safety mindful mindset that offers the opportunity to operate more preemptively during routine quality assurance tasks) and discuss some of our preliminary results from testing our proposed electronic checklist with dosimetrists and physicists.Methods and materials
A multidisciplinary team designed, developed, and evaluated the utility of the electronic checklist (vs paper-based checklist) to promote safety mindfulness. Subjective workload was measured at the end of each assessment/scenario. Performance was quantified on the basis of discovery of purposefully embedded errors, time to complete the scenario, and additional concerns that were documented by the participants.Results
Use of the electronic checklist was associated with decreases in time to scenario completion (P < .01) and increases in documentation of additional patient safety and plan quality concerns (P = .04) but had no significant impact on the recognition of purposefully embedded errors or perceptions of workload.Conclusions
Our proposed principles for the design of electronic checklists may improve the efficiency of quality assurance procedures while enhancing users’ safety mindfulness. Future research is needed to better understand the utility of our proposed design principles on patient safety from a long-term use perspective. 相似文献983.
984.
Joanna Madzio Agata Pastorczak Lukasz Sedek Marcin Braun Joanna Taha Kamila Wypyszczak Joanna Trelinska Monika Lejman Katarzyna Muszynska‐Roslan Bartlomiej Tomasik Katarzyna Derwich Andrzej Koltan Bernarda Kazanowska Nina Irga‐Jaworska Wanda Badowska Michal Matysiak Jerzy Kowalczyk Jan Styczynski Wojciech Fendler Tomasz Szczepanski Wojciech Mlynarski 《Genes, chromosomes & cancer》2019,58(9):619-626
The germline variant at rs3824662 in GATA3 is a risk locus for Philadelphia‐like acute lymphoblastic leukemia (Ph‐like ALL), the biological subtype of B‐cell precursor (BCP)‐ALL defined by a distinct gene expression profile and the presence of specific somatic aberrations including rearrangements of CRLF2. In this study, we investigated whether rs3824662 in GATA3 associates with CRLF2 expression in leukemic cells and predicts prognosis in pediatric BCP‐ALL patients treated according to the ALL Intercontinental Berlin‐Frankfurt‐Münster (IC BFM) 2009 (n = 645) and the ALL IC BFM 2002 (n = 216) protocols. High expression of CRLF2 was observed at both protein and mRNA levels (fourfold higher in AA than in CA + CC) among GATA3 AA variant carriers, independent of the presence of P2RY8‐CRLF2 fusion. Additionally, the AA variant at rs3824662 was a significant factor affecting minimal residual disease level at the end of induction phase and overall survival regardless of the risk group and the protocol. The germline variant at rs3824662 in GATA3 is a prognostic factor which associates with CRLF2 expression in leukemic cells supporting the hypothesis that GATA3 may have a regulatory effect on the CRLF2 pathway in pediatric BCP‐ALL. 相似文献
985.
986.
Wicherek L Basta P Sikora J Galazka K Rytlewski K Grabiec M Lazar A Kalinka J 《American journal of reproductive immunology (New York, N.Y. : 1989)》2007,58(4):358-366
PROBLEM: Pre-eclampsia seems to be related to the disturbance of immune tolerance regulation during pregnancy. Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) decidual level alterations were concomitant with changes in immune cell number and activity in decidua. As decidual immunomodulating activity participates in the development of immune tolerance during pregnancy, we aimed to evaluate the immunoreactivity level of decidual RCAS1 with respect to the presence and activity of immune cells. METHOD OF STUDY: RCAS1, CD3, CD56, CD69, and CD25 immunoreactivity was assessed by immunohistochemistry in 30 decidual samples derived from patients with severe pre-eclampsia (sPE) and from a healthy control group. RESULTS: RCAS1 immunoreactivity was statistically significantly higher in decidual tissue samples derived from patients with sPE tissue than in those derived from healthy patients in whom elective cesarean section at term was performed. A statistically significantly lower number of CD56(+) and CD3(+) cells and lower immunoreactivity level of CD69 were found in patients with sPE compared with those from the control group. CONCLUSION: The limited immune cells infiltration in decidua during sPE is associated with increase in RCAS1 decidual level. 相似文献
987.
988.
Diagnostic and treatment of overactive bladder 总被引:2,自引:0,他引:2
The overactive bladder (OAB) is characterized by symptoms of frequency, urgency, nocturia, and urge incontinence, substantially affecting the quality of life of millions of people throughout the world. Diagnosis of OAB made on patient history, physical examination, and clinical tests can be used as the basis for treatment in most cases. In cases where there is uncertainty regarding the diagnosis, urodynamic assessment should be carried out. Treatment of OAB includes behavioral therapy, pharmacology and, in some cases, surgery. This article reviews current findings regarding diagnostics and treatment of the overactive bladder. 相似文献
989.
Katherine Kedzierska Sophie A. Valkenburg Carole Guillonneau Francois‐Xavier Hubert Tania Cukalac Joan M. Curtis John Stambas Hamish S. Scott Lukasz Kedzierski Vanessa Venturi Miles P. Davenport 《European journal of immunology》2010,40(3):849-858
TCR repertoire diversity is important for the protective efficacy of CD8+ T cells, limiting viral escape and cross‐reactivity between unrelated epitopes. The exact mechanism for selection of restricted versus diverse TCR repertoires is far from clear, although one thought is that the epitopes resembling self‐peptides might select a limited array of TCR due to the deletion of autoreactive TCR. The molecule Aire promotes the expression of tissue‐specific Ag on thymic medullary epithelial cells and the deletion of autoreactive cells, and in the absence of Aire autoreactive cells persist. However, the contribution of Aire‐dependent peptides to the selection of the Ag‐specific TCR repertoire remains unknown. In this study, we dissect restricted (DbNP366%+CD8+) and diverse (DbPA224%+CD8+, KdNP147%+CD8+) TCR repertoires responding to three influenza‐derived peptides in Aire‐deficient mice on both B6 and BALB/c backgrounds. Our study shows that the number, qualitative characteristics and TCR repertoires of all influenza‐specific, DbNP366%+CD8+, DbPA224%+CD8+ and KdNP147%+CD8+ T cells are not significantly altered in the absence of Aire. This provides the first demonstration that the selection of an Ag‐specific T‐cell repertoire is not significantly perturbed in the absence of Aire. 相似文献
990.
Peter V. Draganov Lukasz Kowalczyk Ali Fazel Koorosh Moezardalan Jen-Jung Pan Chris E. Forsmark 《Digestive diseases and sciences》2010,55(2):510-515