全文获取类型
收费全文 | 8778篇 |
免费 | 343篇 |
国内免费 | 45篇 |
专业分类
耳鼻咽喉 | 204篇 |
儿科学 | 151篇 |
妇产科学 | 148篇 |
基础医学 | 1159篇 |
口腔科学 | 1172篇 |
临床医学 | 480篇 |
内科学 | 1943篇 |
皮肤病学 | 166篇 |
神经病学 | 581篇 |
特种医学 | 151篇 |
外科学 | 1284篇 |
综合类 | 25篇 |
一般理论 | 1篇 |
预防医学 | 765篇 |
眼科学 | 172篇 |
药学 | 385篇 |
中国医学 | 75篇 |
肿瘤学 | 304篇 |
出版年
2024年 | 10篇 |
2023年 | 60篇 |
2022年 | 182篇 |
2021年 | 298篇 |
2020年 | 182篇 |
2019年 | 208篇 |
2018年 | 306篇 |
2017年 | 148篇 |
2016年 | 212篇 |
2015年 | 320篇 |
2014年 | 440篇 |
2013年 | 446篇 |
2012年 | 723篇 |
2011年 | 878篇 |
2010年 | 454篇 |
2009年 | 362篇 |
2008年 | 650篇 |
2007年 | 684篇 |
2006年 | 607篇 |
2005年 | 507篇 |
2004年 | 456篇 |
2003年 | 370篇 |
2002年 | 332篇 |
2001年 | 36篇 |
2000年 | 31篇 |
1999年 | 26篇 |
1998年 | 29篇 |
1997年 | 22篇 |
1996年 | 18篇 |
1995年 | 20篇 |
1994年 | 15篇 |
1993年 | 17篇 |
1992年 | 15篇 |
1991年 | 14篇 |
1990年 | 9篇 |
1989年 | 10篇 |
1988年 | 2篇 |
1987年 | 4篇 |
1986年 | 6篇 |
1985年 | 7篇 |
1984年 | 8篇 |
1983年 | 7篇 |
1982年 | 3篇 |
1981年 | 3篇 |
1980年 | 5篇 |
1978年 | 3篇 |
1977年 | 6篇 |
1973年 | 3篇 |
1970年 | 2篇 |
1957年 | 1篇 |
排序方式: 共有9166条查询结果,搜索用时 15 毫秒
81.
82.
Juliana Moscardini Chavasco Bárbara Helena Muniz Prado E Feliphe Claudio Daniel Cerdeira Fabrício Damasceno Leandro Luiz Felipe Leomil Coelho Jéferson Junior da Silva Jorge Kleber Chavasco Amanda Latercia Tranches Dias 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(1):13-20
The antimicrobial activity of plant hidroethanolic extracts on bacteria
Gram positive, Gram negative, yeasts, Mycobacterium tuberculosis H37
and Mycobacterium bovis was evaluated by using the technique of Agar
diffusion and microdilution in broth. Among the extracts evaluated by Agar diffusion,
the extract of Bidens pilosa leaf presented the most expressive
average of haloes of growth inhibition to the microorganisms, followed by the extract
of B. pilosa flower, of Eugenia pyriformis'' leaf
and seed, of Plinia cauliflora leaf which statistically presented
the same average of haloes inhibitory formation on bacteria Gram positive, Gram
negative and yeasts. The extracts of Heliconia rostrata did not
present activity. Mycobacterium tuberculosis H37 and
Mycobacterium bovis (BCG) appeared resistant to all the extracts.
The susceptibility profile of Candida albicans and
Saccharomyces cerevisiae fungi were compared to one another and
to the Gram positive Bacillus subtilis, Enterococcus
faecalis and the Gram negative Salmonella typhimurium
bacteria (p > 0.05). The evaluation of cytotoxicity was carried
out on C6-36 larvae cells of the Aedes albopictus mosquito. The
extracts of stem and flower of Heliconia rostrata, leaf and stem of
Plinia cauliflora, seed of Anonna crassiflora
and stem, flower and root of B. pilosa did not present toxicity in
the analyzed concentrations. The highest rates of selectivity appeared in the
extracts of stem of A. crassiflora and flower of B.
pilosa to Staphylococcus aureus, presenting potential
for future studies about a new drug development. 相似文献
83.
84.
85.
Bruno M.L. Rocha Gonçalo J.L. Cunha Luiz F. Menezes Falcão 《Journal of the American College of Cardiology》2018,71(7):782-793
Heart failure (HF) is highlighted by its burdening symptom-limited exercise capacity and recurrent hospitalizations. Despite substantial advances regarding disease-modifying drugs in HF with reduced ejection fraction, additional therapeutic strategies to improve quality of life are invaluable. Currently, iron deficiency (ID) is overwhelmingly recognized in over 30% to 50% of patients with stable chronic HF, which worsens prognosis. The established pathophysiological mechanisms of progressive HF may be intertwined with increasing myocardial iron scarcity, wherein one begets the other. Most importantly, ID constitutes a novel target for symptom relief in carefully selected patients. In this regard, intravenous iron may be a safe and efficacious intervention, potentially reducing HF hospitalizations. We discuss the evidence and gaps in knowledge concerning iron therapy in HF and propose a practical, comprehensive, clinically oriented algorithm for timely adequate iron replenishment in different clinical scenarios. Finally, we further debate imperative decision-making before intervention and the drawbacks of such a strategy. 相似文献
86.
de Souza Bárbara Capitanio Carteri Randhall Bruce Lopes André Luiz Teixeira Bruno Costa 《Sport Sciences for Health》2021,17(2):279-290
Sport Sciences for Health - This systematic review aimed to investigate the evidence of the interaction between teeth clenching and stimulation on the muscles of the lower and upper limbs. PubMed,... 相似文献
87.
Alice Song Edson Abdala Daniel Waisberg Rodrigo Bronze Martino Ho Yeh Li Luiz Marcelo Sa Malbouisson Ryan Yukimatsu Tanigawa Amaro Duarte Neto Guilherme Marques Andrade Liliana Ducatti Andre Mario Doi João Renato Rebello Pinho Michele Gomes‐Gouvea Fernanda Malta Lecio Figueira Pinto Bruno Fukelmann Guedes Luciana Haddad Venancio Avancini F. Alves Luiz Augusto D. Albuquerque 《The Brazilian journal of infectious diseases》2018
88.
Daniele Santetti Maria Inês de Albuquerque Wilasco Cristina Toscani Leal Dornelles Isabel Cristina Ribas Werlang Fernanda Urruth Fontella Carlos Oscar Kieling Jorge Luiz dos Santos Sandra Maria Gon?alves Vieira Helena Ayako Sueno Goldani 《World journal of gastroenterology : WJG》2015,21(29):8927-8934
AIM: To evaluate the nutritional status and its association with proinflammatory cytokines in children with chronic liver disease.METHODS: We performed a cross-sectional study with 43 children and adolescents, aged 0 to 17 years, diagnosed with chronic liver disease. All patients regularly attended the Pediatric Hepatology Unit and were under nutritional follow up. The exclusion criteria were fever from any etiology at the time of enrollment, inborn errors of the metabolism and any chronic illness. The severity of liver disease was assessed by Child-Pugh, Model for End-stage Liver Disease(MELD) and Pediatric End Stage Liver Disease(PELD) scores. Anthropometric parameters were height/age, body mass index/age and triceps skinfold/age according to World Health Organization standards. The cutoff points for nutritional status were risk of malnutrition(Z-score -1.00) and malnutrition(Z-score -2.00). Interleukin-1β(IL-1β), IL-6 and tumor necrosis factor-α levels were assessed by commercial ELISA kits. For multivariate analysis, linear regression was applied to assess the association between cytokine levels, disease severity and nutritional status. RESULTS: The median(25th-75 th centile) age of the study population was 60(17-116)-mo-old, and 53.5% were female. Biliary atresia was the main cause of chronic liver disease(72%). With respect to Child-Pugh score, cirrhotic patients were distributed as follows: 57.1% Child-Pugh A, a mild presentation of the disease, 34.3% Child-Pugh B, a moderate stage of cirrhosis and 8.6% Child-Pugh C, were considered severe cases. PELD and MELD scores were only above the cutoff point in 5 cases. IL-6 values were increased in patients at nutritional risk(34.9%) compared with those who were well-nourished [7.12(0.58-34.23) pg/m L vs 1.63(0.53-3.43) pg/m L; P = 0.02], correlating inversely with triceps skinfold-for-age z-score(rs =-0.61; P 0.001). IL-6 levels were associated with liver disease severity assessed by Child-Pugh score(P = 0.001). This association remained significant after adjusting for nutritional status in a linear regression model. CONCLUSION: High IL-6 levels were found in children with chronic liver disease at nutritional risk. Inflammatory activity may be related to nutritional status deterioration in these patients. 相似文献
89.
Evaluating Communication Skills of Geriatrics Fellows: Interrater Agreement of an Objective Structured Clinical Examination
下载免费PDF全文
![点击此处可从《Journal of the American Geriatrics Society》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Marcos Daniel Saraiva MD Maria Luiza de Melo Paulo MD Thiago Junqueira Avelino‐Silva MD Luiz Antonio Gil‐Junior MD Elina Lika Kikuchi MD Luciana Louzada Farias MD Rafael Lyra Rodrigues Alves MD Gisele Sayuri Suzuki MD Fábio Cesar Olivieri MD Valmari Cristina Aranha MSc Leonardo da Costa Lopes MD PhD Maria Cristina Guerra Passarelli MD PhD Julio Cesar Moriguti MD PhD Eduardo Ferrioli MD PhD Chao Lung Wen MD PhD Daniel Apolinário MD PhD Wilson Jacob‐Filho MD PhD 《Journal of the American Geriatrics Society》2016,64(1):206-207
90.
Jules Rimet Borges Bárbara Álvares Salum Ximenes Flávia Tandaya Grandi Miranda Giordana Bruna Moreira Peres Isabella Toscano Hayasaki Luiz César de Camargo Ferro Mayra Ianhez Marco Tulio Antonio Garcia-Zapata 《Anais brasileiros de dermatologia》2022,97(4):424-434
BackgroundChromoblastomycosis is a skin infection caused by dematiaceous fungi that take the form of muriform cells in the tissue. It mainly manifests as verrucous plaques on the lower limbs of rural workers in tropical countries.ObjectivesThe primary objective of this review is to evaluate the accuracy of diagnostic methods for the identification of chromoblastomycosis, considering the histopathological examination as the reference test.MethodsMEDLINE, LILACS and Scielo databases were consulted using the terms “chromoblastomycosis” AND “diagnosis”. The eligibility criteria were: studies that evaluated the accuracy of tests for the diagnosis of chromoblastomycosis. Eleven studies were selected. Statistical analysis included the calculation of sensitivity and specificity of the diagnostic methods.ResultsConsidering the histopathological examination as the reference test, the culture showed a sensitivity (S) of 37.5% - 90.9% and a specificity (Sp) of 100%; while direct mycological examination showed S = 50% - 91.6% and Sp of 100% . Considering the culture as the reference test, the serology (precipitation techniques) showed S of 36% - 99%; and Sp of 80% - 100%; while the intradermal test showed S of 83.3% - 100% and Sp of 99.4% - 100%.Study limitationsThe small number of studies and very discrepant sensitivity results among them do not allow the calculation of summary measures through a meta-analysis.ConclusionsDirect mycological examination, culture, intradermal test and serology show sensitivity and specificity values ??for the diagnosis of chromoblastomycosis with no significant difference between the studies. 相似文献