血清睾酮与妊高征发病相关性研究

目的:测定妊高征患者血清睾酮水平并探讨其临床意义。方法:采用放射免疫分析法测定妊高征患者30例、正常孕妇20例血清及其新生儿脐血睾酮水平。结果:妊高征患者血清睾酮水平(0.153±0.078nmol/L)明显高于正常孕妇组(0.023±0.015nmol/L),有显著性差异(P<0.001)。妊高征组脐血睾酮水平(0.052±0.041nmol/L)低于正常孕妇组(0.119±0.059nmol/L),有显著性差异(P<0.05),两组睾酮水平与新生儿性别无关(P>0.05)。结论:孕妇血清睾酮在妊高征的病理生理中起调节或加强作用。     

变形链球菌表面蛋白和葡糖基转移酶基因疫苗对唾液变形链球菌和牙菌斑的影响

目的　了解变形链球菌表面蛋白和葡糖基转移酶基因疫苗单独及联合免疫对定菌鼠唾液变链菌和牙面菌斑的影响。方法　 2 8d龄 Wistar大鼠 3 6只 ,随机分为 pc DNA3 - pac组、pc DNA3 - gtf B组、pc DNA3 - pac联合pc DNA 3 - gtf B组、变形链球菌灭活全菌组、pc DNA3空载体组和 PBS液组 ,进行三次双侧颌下腺腺周注射免疫 ,建立定菌鼠模型 ,作诱龋实验 3个月。唾液变链菌计数和菌斑计分。结果　唾液变链菌菌落计数和牙面菌斑计分在 pc D-NA3与 PBS组最高 ,其次为单基因疫苗免疫组 ,联合基因疫苗和灭活全菌细胞免疫组最低 ,各组间有显著性差异 ( P<0 .0 5 )。结论　 pc DNA3 - gtf B和 pc DNA3 - pac具有明显的免疫抑菌作用 ,联合基因疫苗免疫优于单基因疫苗     

广西毛南族农村妇女铁营养状况调查

对450名广西环江县毛南族农村育龄妇女进行血清铁蛋白(SF)、红细胞游离原卟啉(FEP)及血红蛋白(Hb)3项铁指标测定.结果发现:铁缺乏症患病率为27.8%(其中ID4.2%,IDE 7.8%,IDA 15.8%).随着孕次或产次的增加,血红蛋白水平逐渐下降,铁缺乏症患病率逐渐增高.有妊娠或分娩史的妇女与未孕或未生育的妇女血红蛋白水平与铁缺乏症患病率比较均有显著性差异(P<0.05).     

Chondronecrosis induced in rhesus monkeys fed with grains and water of Kaschin-Beck's disease endemic area]

Immature Rhesus monkeys were fed with grains and/or water of Kashin-Beck disease (KBD) endemic area for 6 or 18 months. Multifocal and zonal chondronecrosis and a series of secondary reactions following necrosis were found in articular cartilage and growth plate in most of the monkeys. These changes are very similar to the characteristics of human KBD. The results suggest that growing Rhesus monkey should be the susceptible animal for reproduction of chondronecrosis model of KBD and the articular cartilage of greater trochanter proximal to femur is a portion predisposing to cartilage lesions. The experiment also indicated that pathogenic factor resulting in chondronecrosis is still remaining in water and grains of endemic area, though the area is no longer actively endemic for KBD.     

非胰岛素依赖型糖尿病患者肺功能检查的初步探讨

对２５例非胰岛素依赖型糖尿病（ＮＩＤＤＭ）患者及２４例正常人进行全套肺功能检查，并作对比分析，结果表明：ＮＩＤＤＭ组比正常对照组Ｖ２５／ＨＴ减低。差异有高度显著性（Ｐ＜０．０１）；ＤＬＣＯ减低差异有显著性（Ｐ＜０．０５），并认为ＮＩＤＤＭ患者小气道功能、弥散功能减低与糖代谢紊乱，致机体抵抗力降低、免疫功能下降，并与肺胞毛细血管基底膜增厚有关。检查ＮＩＤＤＭ患者小气道功能和肺泡弥散功能，具有一定临床意义。     

树鼩中脑腹侧被盖区向尾状核的DOPA能和AChE阳性纤维投射研究

应用荧光逆行标记分别与荧光组化(FAGLU)和AChE-药理组化相结合技术,研究了树鼩中脑腹侧被盖区向尾状核头部的DOPA能和ACHE-阳性纤维投射。结果表明:树鼩中脑腹侧被盖区除分别向同侧和对侧尾状核头部发出DOPA能纤维投射外,还向同侧尾状核头部发出AChE阳性投村纤维;此外,腹侧被盖区存在着向双侧尾核头部发出分叉投射纤维的DOPA能细胞。     

SD大鼠肺中降钙素基因相关肽的分布及缺氧对其含量的影响

本研究用免疫细胞化学方法(ABC法)观察了降钙素基因相关肽(CGRP)在SD大鼠肺中的分布,缺氧对肺中神经内分泌细胞内CGRP含餐的影响。结果表明:含CGRP的神经纤维分布在肺血管平滑肌层中及其周围、气管-支气管树的粘膜下层;含CGRP的神经内分泌细胞位于气管一支气管树的上皮层、粘液腺中和肺实质内。缺氧不引起火鼠肺的神经内分泌细胞数目改变,但可使这些细胞内的CGRP含量增加。     

Comparison between laser and electrical ablation of ventricle in dogs: Hemodynamic,pathologic and electrocardiographic observations

Summary To characterize and compare the pathologic, hemodynamic and electrocardiographic changes of both transeatheter laser and electrical energy on ventricle, 33 subendocardial myocardium lesions were induced at energy 60, 120 and 240 Joules by either transcatheter laser irradiation or electrical shock in 7 anesthetized dogs. The following results were observed: 1) Both laser and electrical ablation on myocardium created nonhomogeneous myocardium injury, but laser ablation caused mainly focal tissue vaporization and necrosis, while electrical shock induced widespread tissue degenerations; 2) Both laser and electrical induced-lesion dimensions increased parallel to the total dosage of energy; 3) Laser ablation caused mainly (90%) single ventricular premature beats and 86 % of them occurred within the first minute after energy discharged, while ventricular tachycardias were found in any electrical energy groups; ventricular fibrillations occurring during laser and electrical ablation were 5 % and 13 % respectively (P< 0.01): 4) A decrease in aortic blood pressure and an increase in central verous pressure induced by laser ablation were significantly less than that produced by the same amount of electrical energy (P<0.0l). Our preliminary results have shown that transeatheter laser ablation has great potential for becoming a practical method in the management of refractory tachycardias.     

171例高血压患者血脂,脂蛋白及载脂蛋白水平的分析

本文就171例HBP患者血脂、脂蛋白及载脂蛋白水平与155例正常人进行比较分析发现:HBP患者WI、TG及apoB较对照组显著升高,TC无明显差别,HDL-C、HDL_2-C及apoAI显著降低、正常男性TC、TG和apoB随年龄增长呈升高趋势,女性TC、TG和LDL-C则在50岁以后开始升高。而HBP患者除男性apoB随年龄增加而升高外,其余各项,不分男女,均无随年龄增减而变化的趋势。