全文获取类型
收费全文 | 909篇 |
免费 | 68篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 29篇 |
妇产科学 | 20篇 |
基础医学 | 185篇 |
口腔科学 | 7篇 |
临床医学 | 71篇 |
内科学 | 216篇 |
皮肤病学 | 20篇 |
神经病学 | 59篇 |
特种医学 | 28篇 |
外科学 | 42篇 |
综合类 | 3篇 |
预防医学 | 78篇 |
眼科学 | 3篇 |
药学 | 114篇 |
中国医学 | 5篇 |
肿瘤学 | 95篇 |
出版年
2024年 | 3篇 |
2023年 | 6篇 |
2022年 | 35篇 |
2021年 | 52篇 |
2020年 | 29篇 |
2019年 | 33篇 |
2018年 | 36篇 |
2017年 | 32篇 |
2016年 | 49篇 |
2015年 | 42篇 |
2014年 | 47篇 |
2013年 | 51篇 |
2012年 | 102篇 |
2011年 | 80篇 |
2010年 | 57篇 |
2009年 | 34篇 |
2008年 | 48篇 |
2007年 | 64篇 |
2006年 | 35篇 |
2005年 | 34篇 |
2004年 | 29篇 |
2003年 | 36篇 |
2002年 | 22篇 |
2001年 | 7篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1998年 | 3篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1989年 | 1篇 |
1986年 | 1篇 |
1984年 | 1篇 |
1981年 | 2篇 |
排序方式: 共有982条查询结果,搜索用时 15 毫秒
11.
Cancer and Metastasis Reviews - Branched-chain amino acids (BCAA) are essential amino acids utilized in anabolic and catabolic metabolism. While extensively studied in obesity and diabetes, recent... 相似文献
12.
Lenka Sedlarikova Barbora Gromesova Veronika Kubaczkova Lenka Radova Jana Filipova Jiri Jarkovsky Lucie Brozova Roberta Velichova Martina Almasi Miroslav Penka Renata Bezdekova Martin Stork Zdenek Adam Ludek Pour Marta Krejci Petr Kuglík Roman Hajek Sabina Sevcikova 《European journal of haematology》2017,99(3):223-233
13.
14.
Health effects of dietary phospholipids 总被引:1,自引:0,他引:1
Daniela Küllenberg Lenka A Taylor Michael Schneider Ulrich Massing 《Lipids in health and disease》2012,11(1):1-16
Beneficial effects of dietary phospholipids (PLs) have been mentioned since the early 1900's in relation to different illnesses and symptoms, e.g. coronary heart disease, inflammation or cancer. This article gives a summary of the most common therapeutic uses of dietary PLs to provide an overview of their approved and proposed benefits; and to identify further investigational needs. From the majority of the studies it became evident that dietary PLs have a positive impact in several diseases, apparently without severe side effects. Furthermore, they were shown to reduce side effects of some drugs. Both effects can partially be explained by the fact that PL are highly effective in delivering their fatty acid (FA) residues for incorporation into the membranes of cells involved in different diseases, e.g. immune or cancer cells. The altered membrane composition is assumed to have effects on the activity of membrane proteins (e.g. receptors) by affecting the microstructure of membranes and, therefore, the characteristics of the cellular membrane, e.g. of lipid rafts, or by influencing the biosynthesis of FA derived lipid second messengers. However, since the FAs originally bound to the applied PLs are increased in the cellular membrane after their consumption or supplementation, the FA composition of the PL and thus the type of PL is crucial for its effect. Here, we have reviewed the effects of PL from soy, egg yolk, milk and marine sources. Most studies have been performed in vitro or in animals and only limited evidence is available for the benefit of PL supplementation in humans. More research is needed to understand the impact of PL supplementation and confirm its health benefits. 相似文献
15.
Introduction:Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired, life-threatening hemopoietic stem cell disorder characterized by the triad of hemolytic anemia, thrombosis, and impaired bone marrow function. Evidence suggests that severe outcomes in COVID19 infection are attributed to the excessive activation of the complement cascade leading to acute lung injury and associated is with an increased prothrombotic state.Patient concerns:A 27-year-old Caucasian man with PNH presented to the Emergency Department of our hospital with acute onset shortness of breath, cough and blood in urine.Diagnosis:The patient was diagnosed with acute hemolytic exacerbation of PNH complicated with moderate COVID19 pneumonia.Outcomes:The patient was initiated with an anticoagulant unfractionated heparin, dexamethasone, and cefuroxime injection. His symptoms quickly resolved, and he was discharged after 5 days.Conclusion:The complement system activation is a critical component in the sequalae of COVID19 infection. Evidence suggests that severe outcomes in COVID19 infection are attributed to the excessive activation of the complement cascade leading to acute lung injury and associated is with an increased prothrombotic state. Notably, C5a concentration was noted to be higher in patients with COVID19 infection. The use of complement inhibitors to attenuate immune mediated damage in COVID19 nevertheless represents a very interesting theoretical approach. However, careful consideration as to which patients may benefit will be required and the outcome of clinical trials needed. 相似文献
16.
Lenka HODACOVA Zdenka SUSTOVA Eva CERMAKOVA Martin KAPITAN Jindra SMEJKALOVA 《Industrial health》2015,53(1):48-55
The purpose of the study was to describe the occurrence of the most common
complaints related to MSDs in Czech dentists and to assess the risk factors affecting
them. A questionnaire survey of 581 Czech dentists (the response rate 72.6%) was conducted
in 2011. The questionnaire ascertained general information about the respondents, their
work habits and environment along with the occurrence of musculoskeletal disorders. The
respondents filled out the questionnaires during the educational events organized by the
Czech Dental Chamber. At least mild difficulties associated with the motoric system were
reported by 96.9% of the respondents, with 66.3% of respondents reporting moderate or
major difficulties. Back and neck pain followed by shoulder pain and headache were the
most common complaints in our sample. According to our data: age, gender, length of
practice, a history of serious MSDs, the occurrence of MSDs in blood relatives, the
perception of work as psychologically demanding, and especially a perceived moderate/bad
general health were significantly associated with the four most common musculoskeletal
complaints. Some of the factors were found as protective. This study suggests that MSDs
represent a significant burden for Czech dentists and further research is needed to
elucidate this issue. 相似文献
17.
Background
Health literacy is a critical determinant of women’s and children’s health and therefore has immense consequences for the health of society as well. Evidence from epidemiological, clinical and experimental studies indicates that unhealthy lifestyles and risky behavioural habits of parents before conception and during pregnancy influence the etiology of various health defects. Decreasing primary risk factors, practicing physical wellness, monitoring physiological markers and preparing for labour, breastfeeding and newborn care should be the main parental responsibilities during the prenatal period.Methods
Our study focused on specifying the main determinants of health literacy among 360 pregnant Czech women by using an anonymous questionnaire and selected anthropometric data of mothers. The criteria for study participation produced a sample representing 1.41% of Czech women in labour during a given 2012 reference period.Results
Despite quite adequate knowledge of both risks and supporting factors for pregnancy and foetal development, the lifestyles of a majority of the women surveyed were far from optimum: only 30% reported good dietary and physical activity habits, 24% were active or passive smokers and one third of the women occasionally drank alcohol, more often among those who were university educated.Conclusion
Our results have confirmed previously published data noting that health literacy and a healthier lifestyle of pregnant women are associated with a higher level of education (except for alcohol drinking) and with contact with a midwife (in some examined parameters) in prenatal courses. 相似文献18.
Hana Bártíková Lenka Skálová Lucie Stuchlíková Ivan Vokřál Tomáš Vaněk 《Drug metabolism reviews》2015,47(3):374-387
Many various xenobiotics permanently enter plants and represent potential danger for their organism. For that reason, plants have evolved extremely sophisticated detoxification systems including a battery of xenobiotic-metabolizing enzymes. Some of them are similar to those in humans and animals, but there are several plant-specific ones. This review briefly introduces xenobiotic-metabolizing enzymes in plants and summarizes present information about their action toward veterinary drugs. Veterinary drugs are used worldwide to treat diseases and protect animal health. However, veterinary drugs are also unwantedly introduced into environment mostly via animal excrements, they persist in the environment for a long time and may impact on the non-target organisms. Plants are able to uptake, transform the veterinary drugs to non- or less-toxic compounds and store them in the vacuoles and cell walls. This ability may protect not only plant themselves but also other organisms, predominantly invertebrates and wild herbivores. The aim of this review is to emphasize the importance of plants in detoxification of veterinary drugs in the environment. The results of studies, which dealt with transport and biotransformation of veterinary drugs in plants, are summarized and evaluated. In conclusion, the risks and consequences of veterinary drugs in the environment and the possibilities of phytoremediation technologies are considered and future perspectives are outlined. 相似文献
19.