全文获取类型
收费全文 | 376篇 |
免费 | 25篇 |
专业分类
耳鼻咽喉 | 1篇 |
妇产科学 | 6篇 |
基础医学 | 79篇 |
口腔科学 | 165篇 |
临床医学 | 10篇 |
内科学 | 65篇 |
皮肤病学 | 1篇 |
神经病学 | 29篇 |
特种医学 | 2篇 |
外科学 | 32篇 |
预防医学 | 1篇 |
药学 | 10篇 |
出版年
2023年 | 2篇 |
2022年 | 1篇 |
2021年 | 13篇 |
2020年 | 4篇 |
2019年 | 8篇 |
2018年 | 8篇 |
2017年 | 4篇 |
2016年 | 6篇 |
2015年 | 6篇 |
2014年 | 10篇 |
2013年 | 20篇 |
2012年 | 12篇 |
2011年 | 23篇 |
2010年 | 7篇 |
2009年 | 10篇 |
2008年 | 23篇 |
2007年 | 29篇 |
2006年 | 23篇 |
2005年 | 29篇 |
2004年 | 24篇 |
2003年 | 21篇 |
2002年 | 7篇 |
2001年 | 16篇 |
2000年 | 13篇 |
1999年 | 8篇 |
1998年 | 5篇 |
1997年 | 3篇 |
1996年 | 4篇 |
1994年 | 3篇 |
1993年 | 3篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1989年 | 5篇 |
1988年 | 7篇 |
1987年 | 1篇 |
1986年 | 4篇 |
1985年 | 5篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1982年 | 8篇 |
1981年 | 4篇 |
1980年 | 2篇 |
1979年 | 7篇 |
1976年 | 1篇 |
1974年 | 1篇 |
1960年 | 1篇 |
排序方式: 共有401条查询结果,搜索用时 0 毫秒
31.
32.
Kaisa E. Luoto Antti Koivukangas Antero Lassila Olli Kampman 《Nordic journal of psychiatry》2016,70(6):470-476
Background: Dual diagnosis (DD) is a common co-morbidity of mental illness and substance use disorder (SUD) and patients with DD are prone to complications. Better knowledge on the outcome, mortality and management of patients with DD in usual secondary psychiatric care would help to inform improved treatment strategies in the future. Aims: To explore the functional outcome and mortality of patients with DD receiving psychiatric treatment. To assess the recognition of substance use disorders (SUDs) in terms of diagnosis, and the associations of clinically diagnosed SUDs with treatment-related variables. Methods: The sample of 330 patients was collected by screening all currently treated patients with the Alcohol Use Disorders Identification Test (AUDIT) and a question about other substances used. The inclusion criteria were AUDIT?>7 and/or reported use of other substances during the preceding 12 months. The Global Assessment of Functioning scale was used to assess functional outcomes during a 2-year follow-up. Information concerning treatment and patient characteristics was collected retrospectively. Results: Level of functioning remained stable among all study patients during follow-up. The mortality rate was not increased. Effective medication use was associated with improved functional outcomes. SUDs were underdiagnosed. A clinically diagnosed SUD seemed to have an impact on the regularity of appointments and the doses of prescribed medications. Conclusions: Given our results suggesting a stable level of functioning, patients with DD appear to be well managed within secondary psychiatric care. Attention should be paid to more precise diagnostics of SUDs and to effective use of medication. 相似文献
33.
The molecular differences between native-type collagen type I fibrils (NC) and their pepsinated monomers (PC) were used to uncover receptors involved in platelet-collagen interaction along the adhesion-activation axis. The platelet-depositing capacity of NC and PC under blood flow and their adhesive properties and respective morphologies, aggregation, procoagulant capacity, and tyrosine phosphorylation were compared under different cationic milieus, including or excluding the glycoprotein (GP) Ia/IIa. NC was consistently a more preferable and activating substrate than PC during flow (5 minutes) and in platelet aggregation. In PPACK-treated blood, both NC (3.3-fold) and PC (2.7-fold) increased platelet attachment on elevation of the shear rate from 500 to 1640 s(-1), whereas in citrated blood, adhesion and thrombus growth on PC were negligible under the high shear rate, unlike on NC (1.9-fold increase). The complete lack of platelet deposition on PC in citrated blood could be overcome by restoring physiological Mg(2+) concentration, and in contrast to NC, platelets interacting with PC were highly dependent on Mg(2+) during adhesion, aggregation, and procoagulant response. Monoclonal antibody (mAb 131.7) against GP IV inhibited platelet deposition to NC in citrated blood (2 minutes) by 49%, which was not further increased by coincubation with mAb against GP Ia (6F1). These results stress the importance of GP Ia/IIa in shear-resistant platelet deposition on collagen monomers. In native fibers, however, the preserved quaternary structure with telopeptides activates additional platelet receptors capable of substituting GP Ia/IIa and GP IV. 相似文献
34.
35.
36.
Fráter Márk Sáry Tekla Molnár Janka Braunitzer Gábor Lassila Lippo Vallittu Pekka K. Garoushi Sufyan 《Clinical oral investigations》2022,26(4):3501-3513
Clinical Oral Investigations - The aim of this in vitro study was to investigate the fatigue survival and fracture behavior of endodontically treated (ET) premolars restored with different types of... 相似文献
37.
Willem M M Fennis Arzu Tezvergil Ruud H Kuijs Lippo V J Lassila Cees M Kreulen Nico H J Creugers Pekka K Vallittu 《Dental materials》2005,21(6):565-572
OBJECTIVES: To assess the fracture resistance and failure mode of fiber reinforced composite (FRC) cusp-replacing restorations in premolars. METHODS: Forty-five extracted sound upper premolars were randomly divided into three groups. Identical MOD cavities with simulated buccal cusp fracture and height reduction of the palatal cusp were prepared. In Group A two layers of resin impregnated woven continuous FRC (EverStick Net) were applied. In Group B one layer of unidirectional continuous FRC (EverStick) was used. In Group C no fibers were applied (control). Subsequently, all teeth were restored with resin composite (Clearfil Photo Posterior), subjected to thermocycling (6000 x 5-55 degrees C) and static load tests. Load until fracture was registered for each tooth. Simultaneously, fracture propagation was monitored using acoustic emission analysis (AE). Failure modes were visually assessed. RESULTS: Weibull analysis revealed a characteristic strength and Weibull modulus (m) at 2364.8 N for Group A (m=8.9), 2437.9 N for Group B (m=5.9) and 2160.3N for Group C (m=13.6). Fracture loads were not significantly different (ANOVA, p>0.05). Teeth with FRC showed less fractures below the cemento-enamel junction (CEJ) (38% and 23% for Groups A and B, respectively) than teeth without FRC (93%) (chi-square, p<0.05). The control group showed the least AE energy signals. SIGNIFICANCE: The results suggest that glass FRC does not increase fracture load of premolars with cusp-replacing restorations. However, FRC has a beneficial effect on the failure mode. Woven fibers give more consistent results than unidirectional fibers. 相似文献
38.
Aino Lepäntalo Kari S. Virtanen Julio C. Reséndiz Jussi Mikkelsson Leena E. Viiri Pekka J. Karhunen Riitta Lassila 《Thrombosis research》2009,124(2):193-198
IntroductionLarge individual variability in clopidogrel responses has been reported. However, mechanisms of the non-responsiveness are unclear. Our aim was to study the extent of platelet inhibition at the receptor level by in vitro receptor antagonists of P2Y12 (AR-C69931MX, cangrelor) and P2Y1 (adenosine 3’,5’diphosphate) in aspirin treated patients with coronary artery disease (CAD) prior to and after in vivo clopidogrel.Materials and Methods51 aspirin-treated (100 mg/day) patients participated. Blood was collected before and after administration of clopidogrel at 300 mg loading dose on day one, followed by 75 mg/d for four days. Aggregation in platelet-rich plasma was assessed.ResultsIn 20% of patients clopidogrel failed to inhibit platelet responses to ADP. These non-responders had also decreased sensitivity to an in vitro P2Y12-receptor antagonist compared with the responders (mean inhibition of aggregation 25 vs. 32%, difference of means 7% (95% CI 2-12%), P < 0.02). Moreover, the P2Y12-receptor inhibition by in vivo clopidogrel correlated with the inhibition by in vitro ARMX measured prior to administration of clopidogrel. Neither P2Y1-receptor activity, thrombin generation while on aspirin nor basal platelet activity associated with clopidogrel responses.ConclusionsConcomitant aspirin and clopidogrel treatment failed to suppress platelet activity in 20% of patients. Non-responders to clopidogrel had decreased responses also to another ADP receptor antagonist, which suggests that the impaired response occurs at the level of P2Y12-receptor. 相似文献
39.
40.
Expression of chL12 Surface Antigen is Associated with Cell Survival in the Avian Bursa of Fabricius
During B-cell development in the avian bursa of Fabricius most of the developing B cells die by apoptosis and only a minority survive to emigrate into the periphery. Recently, it has been shown that when developing bursal cells become mature and ready to migrate they start to express chL12 antigen. The expression of this cell-surface molecule was found to be associated with the survival of the bursal cells both after in vitro culture and after in vivo cyclophosphamide (CY) treatment. The frequency of early apoptotic cells in freshly isolated bursal cells was found to be high. The high susceptibility of these cells to apoptosis is in line with the finding of low bcl-2 mRNA expression. We conclude that expression of avian chL12 antigen is associated with the survival of bursal cells. 相似文献