全文获取类型
收费全文 | 1199篇 |
免费 | 69篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 87篇 |
妇产科学 | 37篇 |
基础医学 | 116篇 |
口腔科学 | 40篇 |
临床医学 | 136篇 |
内科学 | 217篇 |
皮肤病学 | 19篇 |
神经病学 | 71篇 |
特种医学 | 309篇 |
外科学 | 74篇 |
综合类 | 13篇 |
预防医学 | 42篇 |
眼科学 | 6篇 |
药学 | 30篇 |
肿瘤学 | 80篇 |
出版年
2021年 | 8篇 |
2020年 | 5篇 |
2019年 | 6篇 |
2018年 | 14篇 |
2017年 | 8篇 |
2016年 | 8篇 |
2015年 | 16篇 |
2014年 | 20篇 |
2013年 | 28篇 |
2012年 | 21篇 |
2011年 | 19篇 |
2010年 | 36篇 |
2009年 | 27篇 |
2008年 | 19篇 |
2007年 | 41篇 |
2006年 | 27篇 |
2005年 | 32篇 |
2004年 | 26篇 |
2003年 | 15篇 |
2002年 | 13篇 |
2001年 | 14篇 |
2000年 | 16篇 |
1999年 | 28篇 |
1998年 | 97篇 |
1997年 | 71篇 |
1996年 | 76篇 |
1995年 | 52篇 |
1994年 | 54篇 |
1993年 | 61篇 |
1992年 | 15篇 |
1991年 | 14篇 |
1990年 | 22篇 |
1989年 | 45篇 |
1988年 | 31篇 |
1987年 | 42篇 |
1986年 | 24篇 |
1985年 | 35篇 |
1984年 | 24篇 |
1983年 | 16篇 |
1982年 | 22篇 |
1981年 | 23篇 |
1980年 | 28篇 |
1979年 | 6篇 |
1978年 | 16篇 |
1977年 | 18篇 |
1976年 | 20篇 |
1975年 | 13篇 |
1933年 | 1篇 |
1932年 | 1篇 |
1930年 | 1篇 |
排序方式: 共有1279条查询结果,搜索用时 31 毫秒
991.
BACKGROUND: Prior clinical trials suggest that the Transcendental Meditation technique may decrease blood pressure of normotensive and hypertensive individuals but study-quality issues have been raised. This study was designed to assess effects of Transcendental Meditation on blood pressure using objective quality assessments and meta-analyses. METHODS: PubMed and Cochrane databases through December 2006 and collected publications on Transcendental Meditation were searched. Randomized, controlled trials comparing blood pressure responses to the Transcendental Meditation technique with a control group were evaluated. Primary outcome measures were changes in systolic and diastolic blood pressure after practicing Transcendental Meditation or following control procedures. A specific rating system (0-20 points) was used to evaluate studies and random-effects models were used for meta-analyses. RESULTS: Nine randomized, controlled trials met eligibility criteria. Study-quality scores ranged from low (score, 7) to high (16) with three studies of high quality (15 or 16) and three of acceptable quality (11 or 12). The random-effects meta-analysis model for systolic and diastolic blood pressure, respectively, indicated that Transcendental Meditation, compared to control, was associated with the following changes: -4.7 mm Hg (95% confidence interval (CI), -7.4 to -1.9 mm Hg) and -3.2 mm Hg (95% CI, -5.4 to -1.3 mm Hg). Subgroup analyses of hypertensive groups and high-quality studies showed similar reductions. CONCLUSIONS: The regular practice of Transcendental Meditation may have the potential to reduce systolic and diastolic blood pressure by approximately 4.7 and 3.2 mm Hg, respectively. These are clinically meaningful changes. 相似文献
992.
993.
CK Ong LL Wang RJ Parkinson JD Wenderoth 《Journal of Medical Imaging and Radiation Oncology》2009,53(3):291-295
The cavernous sinus dural arteriovenous fistulas of three patients were successfully embolised by using Onyx (Onyx Liquid Embolic System, MTI, Irvine, CA, USA) as the sole embolic agent, through direct percutaneous transorbital punctures of the cavernous sinuses. Our early experience suggests that this direct approach, coupled with the unique physical properties of Onyx, is a safe and effective alternative to treat cavernous sinus dural arteriovenous fistulas when the conventional transvenous routes are inaccessible. 相似文献
994.
Jeffrey W. Elder Edward J. Pavlik Ashleigh Long Rachel W. Miller Christopher P. DeSimone John T. Hoff Walker R. Ueland Richard J. Kryscio John R. van Nagell Jr. Frederick R. Ueland 《Gynecologic oncology》2014
Objective
Transvaginal ultrasonography with tumor morphology index (MI) has been used to predict the risk of ovarian malignancy. Our objective was to analyze changes in serial MI scores for malignant and non-malignant ovarian tumors in a large and asymptomatic population.Methods
Eligible subjects participated in the University of Kentucky Ovarian Cancer Screening Program and had abnormalities that included cysts, cysts with septations, complex cysts with solid areas, and solid masses. Analysis included: MI, change in MI (delta MI), delta MI per scan and per month, number and duration of scans.Results
From 1987 to 2012, 38,983 women received 218,445 scans. Of the 7104 eligible subjects, 6758 tumors were observed without surgery and 472 were surgically removed. Eighty-six percent (5811) of observed tumors were resolved. There were 74 malignant and 272 non-malignant tumors. Eighty-five percent of malignancies had MI ≥ 5 at decision for surgery. The risk of malignancy based on MI was: MI = 5 (3%), MI = 6 (3.7%), MI = 7 (12.6%), MI = 8 (26.7%), MI = 9 (27.8%), MI = 10 (33.3%). The mean delta MI per month decreased for tumors that resolved (delta MI − 1.0, p < 0.001) or persisted without surgery (delta MI − 0.7, p < 0.001). For abnormalities surgically removed, the mean delta MI per month increased significantly more for malignancies than for benign tumors (delta MI + 1.6 vs. + 0.3, p < 0.001).Conclusions
The mean MI for malignant ovarian tumors increases over time, while non-malignant tumors have a decreasing or stable MI. Serial MI analysis can improve the prediction of ovarian malignancy by reducing false-positive results, thereby decreasing the number of operations performed for benign abnormalities. 相似文献995.
Erin L. Abner PhD Richard J. Kryscio PhD Frederick A. Schmitt PhD David W. Fardo PhD Daniela C. Moga MD PhD Eseosa T. Ighodaro BS Gregory A. Jicha MD PhD Lei Yu PhD Hiroko H. Dodge PhD Chengjie Xiong PhD Randall L. Woltjer MD PhD Julie A. Schneider MD Nigel J. Cairns PhD FRCPath David A. Bennett MD Peter T. Nelson MD PhD 《Annals of neurology》2017,81(4):549-559
996.
997.
R A Patchell P A Tibbs J W Walsh R J Dempsey Y Maruyama R J Kryscio W R Markesbery J S Macdonald B Young 《The New England journal of medicine》1990,322(8):494-500
To assess the efficacy of surgical resection of brain metastases from extracranial primary cancer, we randomly assigned patients with a single brain metastasis to either surgical removal of the brain tumor followed by radiotherapy (surgical group) or needle biopsy and radiotherapy (radiation group). Forty-eight patients (25 in the surgical group and 23 in the radiation group) formed the study group; 6 other patients (11 percent) were excluded from the study because on biopsy their lesions proved to be either second primary tumors or inflammatory or infectious processes. Recurrence at the site of the original metastasis was less frequent in the surgical group than in the radiation group (5 of 25 [20 percent] vs. 12 of 23 [52 percent]; P less than 0.02). The overall length of survival was significantly longer in the surgical group (median, 40 weeks vs. 15 weeks in the radiation group; P less than 0.01), and the patients treated with surgery remained functionally independent longer (median, 38 weeks vs. 8 weeks in the radiation group; P less than 0.005). We conclude that patients with cancer and a single metastasis to the brain who receive treatment with surgical resection plus radiotherapy live longer, have fewer recurrences of cancer in the brain, and have a better quality of life than similar patients treated with radiotherapy alone. 相似文献
998.
DeSimone CP Van Ness JS Cooper AL Modesitt SC DePriest PD Ueland FR Pavlik EJ Kryscio RJ van Nagell JR 《Gynecologic oncology》2007,104(2):390-395
OBJECTIVE: To determine the pattern of lymph node metastases, recurrence rate, and survival of patients with lateral T1 and T2 squamous cell cancer (SCC) of the vulva treated by radical vulvectomy or hemivulvectomy and inguinal lymphadenectomy. METHODS: An institutional review was performed to identify lateral T1 and T2 SCC of the vulva confined to the labium majus and minus. RESULTS: Sixty-one patients with lateral T1 and 61 patients with lateral T2 SCC of the vulva were treated from 1963 to 2003. Radical vulvectomy (RV) was performed in 60 patients, and radical hemivulvectomy (RHV) in 62 patients. Seven of 61 patients (11%) with T1 lesions had ipsilateral superficial inguinal lymph node (SIL) metastases, but none had deep inguinal lymph (DIL) node metastases. Nineteen of 61 patients (31%) with T2 lesions had ipsilateral SIL metastases, and 8 had ipsilateral DIL metastases. No patient had contralateral SIL or DIL metastases. Six patients (10%) with T1 lesions and seven patients (11%) with T2 lesions developed recurrence to the ipsilateral vulva and were treated by re-excision. All patients are alive with no evidence of disease 10-195 months after treatment. One patient with T1 and three patients with T2 SCC developed distant recurrence and died of disease (DOD) 10-15 months after surgery. Disease-free survival of patients with T1 lesions was 98% at 2 years and 98% at 5 years, and with T2 lesions was 95% at 2 years and 93% at 5 years. Local or distant recurrence was not more common in patients treated by RHV than in those treated by RV. CONCLUSION: Lateral T1 and T2 squamous cell cancers of the vulva spread to the ipsilateral inguinal lymph nodes and can be treated effectively with RHV and ipsilateral SIL dissection. Deep inguinal lymphadenectomy is indicated only when the SIL are positive. 相似文献
999.
尽管心血管疾病的诊断和急性事件的治疗得到了高度重视,但针对减少心血管事件反复再发的继续治疗即二级预防却没有得到应有的关注。过去的15年,心脏康复已经逐渐成为心血管疾病二级预防的一项标准治疗,持续不断的证据显示了心脏康复改善生活质量的诸多益处,在世界范围内心脏康复已经被包含在心血管疾病诊疗的临床实践指南中。尽管如此心脏康复并没有被充分应用,尤其在发展中国家。本综述主要描述心脏康复的基本概念、核心构成和相关益处。 相似文献
1000.
Narayana Manjunatha Sahoo Saddichha Baxi NP Sinha Christoday RJ Khess Mohan K Isaac 《Indian Journal of Community Medicine》2008,33(4):233-237