全文获取类型
收费全文 | 8738篇 |
免费 | 1416篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 196篇 |
儿科学 | 51篇 |
妇产科学 | 70篇 |
基础医学 | 261篇 |
口腔科学 | 6614篇 |
临床医学 | 282篇 |
内科学 | 706篇 |
皮肤病学 | 127篇 |
神经病学 | 258篇 |
特种医学 | 182篇 |
外科学 | 830篇 |
综合类 | 8篇 |
预防医学 | 147篇 |
眼科学 | 43篇 |
药学 | 85篇 |
中国医学 | 1篇 |
肿瘤学 | 319篇 |
出版年
2024年 | 21篇 |
2023年 | 362篇 |
2022年 | 35篇 |
2021年 | 121篇 |
2020年 | 147篇 |
2019年 | 58篇 |
2018年 | 295篇 |
2017年 | 371篇 |
2016年 | 419篇 |
2015年 | 500篇 |
2014年 | 534篇 |
2013年 | 542篇 |
2012年 | 417篇 |
2011年 | 390篇 |
2010年 | 421篇 |
2009年 | 620篇 |
2008年 | 354篇 |
2007年 | 333篇 |
2006年 | 299篇 |
2005年 | 294篇 |
2004年 | 245篇 |
2003年 | 307篇 |
2002年 | 240篇 |
2001年 | 201篇 |
2000年 | 169篇 |
1999年 | 187篇 |
1998年 | 255篇 |
1997年 | 216篇 |
1996年 | 209篇 |
1995年 | 187篇 |
1994年 | 176篇 |
1993年 | 131篇 |
1992年 | 151篇 |
1991年 | 103篇 |
1990年 | 116篇 |
1989年 | 69篇 |
1988年 | 100篇 |
1987年 | 91篇 |
1986年 | 49篇 |
1985年 | 75篇 |
1984年 | 68篇 |
1983年 | 62篇 |
1982年 | 53篇 |
1981年 | 37篇 |
1978年 | 14篇 |
1977年 | 14篇 |
1976年 | 12篇 |
1975年 | 16篇 |
1974年 | 16篇 |
1972年 | 18篇 |
排序方式: 共有10000条查询结果,搜索用时 813 毫秒
71.
72.
Yoshikiyo Akasaka MD PhD ; Kinji Ito PhD ; Kazuko Fujita PhD ; Kazuo Komiyama DDS ; Ichiro Ono MD PhD ; Yukio Ishikawa MD PhD ; Yuri Akishima MD PhD ; Hiroko Sato MD PhD ; Toshiharu Ishii MD PhD 《Wound repair and regeneration》2005,13(4):373-382
To characterize apoptosis in keloids and the mechanisms responsible for this process, the expression of activated caspase-9 and -3 in fibroblasts obtained from keloids was analyzed. Immunohistochemistry revealed that the number of fibroblasts positive for terminal deoxynucleotide transferase-mediated dUTP nick-end labeling (TUNEL) or activated caspase-9 or -3 was low but was significantly higher in keloid tissues than in normal scar tissues. Significant relationships between the number of caspase-positive fibroblasts and TUNEL-positive fibroblasts suggested that the activation of caspase-9 and -3 induces apoptosis in a subpopulation of keloid fibroblasts. All keloid fibroblast cell lines established in this study showed activation of caspase-9 and -3 after serum deprivation for 3 or 4 hours, as shown using Western blotting. Furthermore, serum deprivation-induced apoptosis in a keloid fibroblast line was blocked by a caspase-9 inhibitor (acetyl-Leu-Glu-His-Asp-al), indicating that activation of caspase-9 was necessary for the process of apoptosis in keloid fibroblasts. Although serum deprivation did not significantly change the level of apoptosis protease activating factor-1 in any of the lines, cytochrome c release was detected in cytosolic fractions of the lines after serum deprivation for 3 or 4 hours. These results strongly suggest that keloid fibroblasts are predisposed to apoptosis and cytochrome c release and that caspase-9 activation may underlie regulation of apoptosis in keloid fibroblasts in vivo. 相似文献
73.
Prognostic factors in patients with ipsilateral pulmonary metastasis from non-small cell lung cancer. 总被引:2,自引:0,他引:2
Tatsuo Nakagawa Norihito Okumura Kentaro Miyoshi Tomoaki Matsuoka Kotaro Kameyama 《European journal of cardio-thoracic surgery》2005,28(4):635-639
OBJECTIVE: Pulmonary metastasis of non-small cell lung cancer is classified as an advanced disease stage, with limited indications for surgical treatment. However, the prognosis of patients with pulmonary metastasis of non-small cell lung cancer is better than that of patients with distant metastases. The purpose of the present study was to analyze and detect possible prognostic factors in surgically treated patients with ipsilateral pulmonary metastasis of non-small cell lung cancer. METHODS: Among 1198 patients with non-small cell lung cancer who underwent surgery at Kurashiki Central Hospital (Okayama, Japan) from April 1982 to March 2004, a total of 48 (4.0%) patients with pathologically diagnosed ipsilateral pulmonary metastasis were retrospectively evaluated. The median follow-up time was 20.5 months (range 1-103 months) and 37 patients (77.1%) were completely followed up until their death or more than 5 years after the operation. RESULTS: Among the 48 patients, 31 (64.6%) patients had metastatic nodules in the same lobe as the primary tumor (PM1) and 17 (35.4%) patients had metastatic nodules in different ipsilateral lobes (PM2). There was no significant difference in survival between patients with PM1 and the other patients with pT4-stage IIIB, or between patients with ipsilateral PM2 and the other patients with stage IV. Univariate analysis of postoperative survival stratified according to clinicopathologic factors revealed significant differences for the radicality of resection (complete vs. incomplete), tumor size (0-30 vs. >30mm) and pathological nodal (pN) factor (among pN0, pN1 and pN2-3). Multivariate analysis revealed that tumor size (0-30 vs. >30mm) and pN factor (pN0-1 vs. pN2-3) were independent prognostic factors. CONCLUSIONS: The results of our study suggest that undergoing a complete resection, having a tumor size of 30mm or less and having no mediastinal lymph node metastases were better prognostic factors for surgically treated patients with ipsilateral pulmonary metastasis of non-small cell lung cancer. 相似文献
74.
75.
76.
77.
Anette M.C. Fransson DDS A
ke Tegelberg DDS PhD Anders Johansson DDS PhD Bengt Wenneberg DDS PhD 《American journal of orthodontics and dentofacial orthopedics》2004,126(6):687-693
The aim was to identify the incidence and types of possible adverse events in the masticatory system after treatment with a mandibular protruding device (MPD) during a 2-year period in patients with obstructive sleep apnea (OSA) or snoring. The subjects comprised 65 middle-aged patients (44 OSA patients, 21 snorers). A clinical examination and a questionnaire concerning signs and symptoms from the masticatory system were performed before, after 6 months, and after 2 years of MPD use. The frequencies of registered signs from the masticatory system, such as muscle and joint tenderness, palpation, and pain during mandibular movement, decreased significantly between baseline and the 2-year follow-up. There were significant changes in the mandibular range of protrusion (+0.7 mm, P < .001), overjet (-0.5 mm, P < .001), and overbite (-0.6 mm, P < .001) compared with the initial examination. Nine patients developed a lateral open bite during treatment, and 2 of them experienced subjective symptoms related to the altered occlusion but still used the MPD every night. No patient reported pain on opening the mouth wide or during jaw movements. Two reported tiredness on jaw function. The reported frequency of headaches was also significantly reduced (P < .01). The high compliance rate in MPD use showed that the therapy is well tolerated, but there is a risk of minor alterations in the occlusion during MPD treatment. 相似文献
78.
79.
80.