全文获取类型
收费全文 | 1103篇 |
免费 | 56篇 |
国内免费 | 29篇 |
专业分类
耳鼻咽喉 | 49篇 |
儿科学 | 46篇 |
妇产科学 | 34篇 |
基础医学 | 58篇 |
口腔科学 | 85篇 |
临床医学 | 101篇 |
内科学 | 378篇 |
皮肤病学 | 19篇 |
神经病学 | 59篇 |
特种医学 | 31篇 |
外科学 | 172篇 |
综合类 | 23篇 |
预防医学 | 25篇 |
眼科学 | 8篇 |
药学 | 66篇 |
中国医学 | 2篇 |
肿瘤学 | 32篇 |
出版年
2023年 | 8篇 |
2022年 | 10篇 |
2021年 | 19篇 |
2020年 | 23篇 |
2019年 | 28篇 |
2018年 | 27篇 |
2017年 | 22篇 |
2016年 | 41篇 |
2015年 | 44篇 |
2014年 | 51篇 |
2013年 | 68篇 |
2012年 | 76篇 |
2011年 | 66篇 |
2010年 | 56篇 |
2009年 | 47篇 |
2008年 | 86篇 |
2007年 | 92篇 |
2006年 | 84篇 |
2005年 | 76篇 |
2004年 | 71篇 |
2003年 | 43篇 |
2002年 | 31篇 |
2001年 | 19篇 |
2000年 | 21篇 |
1999年 | 25篇 |
1998年 | 9篇 |
1997年 | 6篇 |
1996年 | 3篇 |
1995年 | 4篇 |
1994年 | 2篇 |
1993年 | 4篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 8篇 |
1988年 | 3篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有1188条查询结果,搜索用时 25 毫秒
81.
Outcome of orthoses intervention in the rheumatoid foot 总被引:4,自引:0,他引:4
Kavlak Y Uygur F Korkmaz C Bek N 《Foot & ankle international / American Orthopaedic Foot and Ankle Society [and] Swiss Foot and Ankle Society》2003,24(6):494-499
This study was carried out to determine the effect of foot orthoses on pain, gait, and energy expenditure in patients with rheumatoid arthritis. Eighteen patients were evaluated for these parameters. Each patient was given a foot insert or shoe modification suitable for his or her foot deformity. Following 3 months of orthosis use, a significant difference was found in regards to pain (p < .05), step length and stride length (p < .05), and physiological cost index (p < .05). The results suggest that foot orthoses are an important feature in the rehabilitation of the rheumatoid foot. 相似文献
82.
Adnan Narc? Mevlit Korkmaz Muhittin Karaku? Tolga Altu? ?en ?lham? Surer Salih ?etinkur?un 《Canadian Urological Association journal》2010,4(3):E61-E63
Crossed renal ectopy (CRE) is the second most common fusion anomaly of the kidney, with an incidence of 1 in 7000 autopsies; it comes in second after horseshoe kidney. Crossed renal ectopy is associated with an ectopic ureter and generally an ectopic kidney fused with a normal kidney. A 7-month-old boy who had left-to-right crossed non-fused renal ectopy and multicystic renal dysplasia with ureterocele in nonectopic kidney was reported in English language literature. In this article, we present the first case of CRE where surgical intervention has been performed. 相似文献
83.
L C Platanias S Uddin E Bruno M Korkmaz S Ahmad Y Alsayed D Van Den Berg B J Druker A Wickrema R Hoffman 《Experimental hematology》1999,27(8):1315-1321
Interferons are potent regulators of normal and malignant hematopoietic cell proliferation in vitro and in vivo, but the signaling mechanisms by which they exhibit their growth inhibitory effects are unknown. We have recently shown that CrkL is engaged in Type I IFN signaling, as shown by its rapid tyrosine phosphorylation during engagement of the Type I IFN receptor. In the present study, we provide evidence that the related CrkII protein is also rapidly phosphorylated on tyrosine during treatment of U-266 and Daudi cells with IFNalpha or IFNbeta. We also show that both members of the Crk-family, CrkL and CrkII, are phosphorylated in an interferon-dependent manner in primary hematopoietic progenitors. Furthermore, inhibition of CrkL or CrkII protein expression by antisense oligonucleotides, reverses the inhibitory effects of IFNalpha or IFNgamma on the proliferation of normal bone marrow progenitor cells (colony forming units-granulocytic/monocytic [CFU-GM] and burst-forming units-erythroid [BFU-E]). Thus, both CrkL and CrkII are engaged in a signaling pathway (s) that mediates interferon-regulated inhibition of hematopoietic cell proliferation. 相似文献
84.
85.
Lale Altan Nimet Korkmaz Ümit Bingol Berna Gunay 《Archives of physical medicine and rehabilitation》2009,90(12):1983-1988
Altan L, Korkmaz N, Bingol Ü, Gunay B. Effect of Pilates training on people with fibromyalgia syndrome: a pilot study.ObjectiveTo investigate the effects of Pilates on pain, functional status, and quality of life in fibromyalgia, which is known to be a chronic musculoskeletal disorder.DesignRandomized, prospective, controlled, and single-blind trial.SettingPhysical medicine and rehabilitation department.ParticipantsWomen (N=50) who had a diagnosis of fibromyalgia syndrome (FMS) according to the American College of Rheumatology criteria.InterventionThe participants were randomly assigned into 2 groups. In group 1, a Pilates exercise program of 1 hour was given by a certified trainer to 25 participants 3 times a week for 12 weeks. In group 2, which was designed as the control group, 25 participants were given a home exercise (relaxation/stretching) program. In both groups, pre- (week 0) and posttreatment (week 12 and week 24) evaluation was performed by one of the authors, who was blind to the group allocation.Main Outcome MeasuresPrimary outcome measures were pain (visual analog scale) and Fibromyalgia Impact Questionnaire (FIQ). Exploratory outcome measures were number of tender points, algometric score, chair test, and Nottingham Health Profile.ResultsTwenty-five Pilates exercise and 24 relaxation/stretching exercise participants completed the study. In group 1, significant improvement was observed in both pain and FIQ at week 12 but only in FIQ at 24 weeks. In group 2, no significant improvement was obtained in pain and FIQ at week 12 and week 24. Comparison of the 2 groups showed significantly superior improvement in pain and FIQ in group 1 at week 12 but no difference between the 2 groups at week 24.ConclusionsWe suggest Pilates as an effective and safe method for people with FMS. Our study is the first clinical study designed to investigate the role of the Pilates method in FMS treatment. We believe that further research with more participants and longer follow-up periods could help assess the therapeutic value of this popular physical exercise method. 相似文献
86.
Björn Wettermark Marie E Persson Nils Wilking Mats Kalin Seher Korkmaz Paul Hjemdahl Brian Godman Max Petzold Lars L Gustafsson the Regional Drug Expert Consortium in Stockholm County Council 《BMC health services research》2010,10(1):128
Background
New pharmacological therapies are challenging the healthcare systems, and there is an increasing need to assess their therapeutic value in relation to existing alternatives as well as their potential budget impact. Consequently, new models to introduce drugs in healthcare are urgently needed. In the metropolitan health region of Stockholm, Sweden, a model has been developed including early warning (horizon scanning), forecasting of drug utilization and expenditure, critical drug evaluation as well as structured programs for the introduction and follow-up of new drugs. The aim of this paper is to present the forecasting model and the predicted growth in all therapeutic areas in 2010 and 2011. 相似文献87.
Demirci M Tunc SE Delibas N Tamer MN Altuntas I Korkmaz M 《Wiener klinische Wochenschrift》2003,115(5-6):182-185
BACKGROUND: The prevalence of autoimmune thyroid diseases and autoantibodies in patients with chronic fasciolosis (CF) was investigated. METHODS: Thyroid function of 32 patients with CF and 72 patients without fasciolosis infection was evaluated biochemically. Thyroid hormones, antithyroglobulin antibodies (TgAb) and antithyroid peroxidase antibodies (TPOAb) were measured. RESULTS: In patients with CF, the prevalences of autoantibodies against thyroid peroxidase and thyroglobulin were 21.9% (7/32) and 15.6% (5/32) respectively. However, thyroid function disorder was identified in only 3 (9.4%) cases. In the control group, TPOAb and TgAb were determined in 2 (2.7%) cases, but no one had thyroid function disorder. The prevalences of thyroid autoantibodies (chi 2: 7.948, p < 0.01) and autoimmune thyroid diseases (chi 2: 4.007, p < 0.05) were significantly higher in the CF group. CONCLUSIONS: The high prevalence of TPOAb and TgAb in CF suggests that patients with CF should be evaluated for autoimmune thyroid disorders at the time of diagnosis and during the follow-up period. 相似文献
88.
89.
Bozbas H Yildirir A Mermer S Konas D Atar I Aydinalp A Ozin B Korkmaz ME Muderrisoglu H 《Advances in therapy》2007,24(3):493-504
Serum cardiac enzyme elevation after percutaneous coronary intervention (PCI), a relatively common complication, is a prognostic
determinant of long-term outcome in patients who undergo these procedures. Statins are postulated to reduce such complications.
This study investigated the short-term effects of pravastatin on serum creatine kinase myocardial isoform (CK-MB) and serum
cardiac troponin I (cTpI) levels after elective PCI. Of 93 patients studied, 72 (77.4%) were men, and 21 (22.6%) were women
(mean age, 58.9±11.0 y). Patients were randomly divided into 3 groups before they underwent elective PCI. Preoperatively,
group 1 patients (n=30) received pravastatin 10 mg/d, and group 2 patients (n=29) received pravastatin 40 mg/d. Control group
patients (n=34) received no lipid-lowering medication. Serum CK-MB and serum cTpI levels were measured preoperatively and
then again at 6, 24, and 36 h postoperatively. Demographic features of patients and characteristics of the PCI procedure,
including number of vessels/lesions and duration and number of inflations, did not differ among groups (P>.05). Mean serum CK-MB and serum cTpI levels were significantly increased after PCI in all patients (P<.001). When compared with control group patients, those given pravastatin did not experience significantly lowered postprocedural
serum CK-MB or serum cTpI levels (P>.05). Preprocedural pravastatin therapy at dosages of 10 mg/d and 40 mg/d seems inadequate for preventing serum cardiac enzyme
elevations during short-term follow-up after PCI. Additional research on this topic is recommended. 相似文献
90.
Ulucam M Yildirir A Muderrisoglu H Yakupoglu U Korkmaz ME Ozdemir N Ozin B Tayfun E 《Advances in therapy》2004,21(2):96-106
The myocardial performance index (MPI) reflects global ventricular function. Chronic hypervolemia and uremia may negatively
affect the myocardium of both ventricles. The aims of this study were to investigate how chronic renal failure (CRF) affects
biventricular MPI and to determine whether preload reduction by hemodialysis (HD) affects left ventricular MPI (LVMPI) and
right ventricular MPI (RVMPI) in CRF. Twenty-one patients with CRF (group 1) were examined 1 hour before and 1 hour after
an HD session and 1 7 healthy control patients (group 2) were examined once by echocardiography. The MPI for each ventricle
was calculated as the sum of isovolumic time intervals divided by the ejection time. Before HD, the LVMPI of group 1 was similar
to that in group 2 (P≫.05), but the RVMPI of group 1 was significantly higher (P=.007). After the HD session, LVMPI and RVMPI remained unchanged (P>.05 for both). The LVMPI and RVMPI were not correlated either before or after HD in group 1 (P>.05 for both), whereas they were correlated in group 2 (r= 0.671, P=.003). Chronic renal failure causes isolated RV dysfunction, as reflected by increased RVMPI values. Preload reduction
by HD does not affect LVMPI or RVMPI. Patients with CRF also do not exhibit the correlation of LVMPI and RVMPI that is observed
in healthy individuals. 相似文献