全文获取类型
收费全文 | 6030篇 |
免费 | 261篇 |
国内免费 | 102篇 |
专业分类
耳鼻咽喉 | 63篇 |
儿科学 | 71篇 |
妇产科学 | 172篇 |
基础医学 | 443篇 |
口腔科学 | 198篇 |
临床医学 | 441篇 |
内科学 | 1998篇 |
皮肤病学 | 84篇 |
神经病学 | 401篇 |
特种医学 | 226篇 |
外科学 | 1302篇 |
综合类 | 27篇 |
现状与发展 | 1篇 |
一般理论 | 2篇 |
预防医学 | 220篇 |
眼科学 | 131篇 |
药学 | 238篇 |
中国医学 | 3篇 |
肿瘤学 | 372篇 |
出版年
2024年 | 6篇 |
2023年 | 70篇 |
2022年 | 150篇 |
2021年 | 276篇 |
2020年 | 163篇 |
2019年 | 218篇 |
2018年 | 263篇 |
2017年 | 155篇 |
2016年 | 191篇 |
2015年 | 178篇 |
2014年 | 292篇 |
2013年 | 338篇 |
2012年 | 509篇 |
2011年 | 548篇 |
2010年 | 350篇 |
2009年 | 311篇 |
2008年 | 442篇 |
2007年 | 467篇 |
2006年 | 427篇 |
2005年 | 312篇 |
2004年 | 258篇 |
2003年 | 184篇 |
2002年 | 147篇 |
2001年 | 31篇 |
2000年 | 9篇 |
1999年 | 13篇 |
1998年 | 25篇 |
1997年 | 13篇 |
1996年 | 8篇 |
1995年 | 8篇 |
1994年 | 15篇 |
1993年 | 2篇 |
1992年 | 3篇 |
1991年 | 3篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1984年 | 2篇 |
1979年 | 1篇 |
1975年 | 2篇 |
1969年 | 1篇 |
排序方式: 共有6393条查询结果,搜索用时 15 毫秒
101.
Ilias Karaiskos Lena E. Friberg Konstantinos Pontikis Konstantinos Ioannidis Vasiliki Tsagkari Lamprini Galani Eirini Kostakou Fotini Baziaka Charalambos Paskalis Antonia Koutsoukou Helen Giamarellou 《Antimicrobial agents and chemotherapy》2015,59(12):7240-7248
Colistin has been revived, in the era of extensively drug-resistant (XDR) Gram-negative infections, as the last-resort treatment in critically ill patients. Recent studies focusing on the optimal dosing strategy of colistin have demonstrated the necessity of a loading dose at treatment initiation (D. Plachouras, M. Karvanen, L. E. Friberg, E. Papadomichelakis, A. Antoniadou, I. Tsangaris, I. Karaiskos, G. Poulakou, F. Kontopidou, A. Armaganidis, O. Cars, and H. Giamarellou, Antimicrob Agents Chemother 53:3430–3436, 2009, http://dx.doi.org/10.1128/AAC.01361-08; A. F. Mohamed, I. Karaiskos, D. Plachouras, M. Karvanen, K. Pontikis, B. Jansson, E. Papadomichelakis, A. Antoniadou, H. Giamarellou, A. Armaganidis, O. Cars, and L. E. Friberg, Antimicrob Agents Chemother 56:4241– 4249, 2012, http://dx.doi.org/10.1128/AAC.06426-11; S. M. Garonzik, J. Li, V. Thamlikitkul, D. L. Paterson, S. Shoham, J. Jacob, F. P. Silveira, A. Forrest, and R. L. Nation, Antimicrob Agents Chemother 55:3284–3294, 2011, http://dx.doi.org/10.1128/AAC.01733-10). In 19 critically ill patients with suspected or microbiologically documented infections caused by XDR Gram-negative strains, a loading dose of 9 MU colistin methanesulfonate (CMS) (∼270 mg colistin base activity) was administered with a maintenance dose of 4.5 MU every 12 h, commenced after 24 h. Patients on renal replacement were excluded. CMS infusion was given over 30 min or 1 h. Repeated blood sampling was performed after the loading dose and after the 5th or 6th dose. Colistin concentrations and measured CMS, determined after hydrolization to colistin and including the partially sulfomethylated derivatives, were determined with a liquid chromatography-tandem mass spectrometry assay. Population pharmacokinetic analysis was conducted in NONMEM with the new data combined with data from previous studies. Measured colistimethate concentrations were described by 4 compartments for distribution and removal of sulfomethyl groups, while colistin disposition followed a 1-compartment model. The average observed maximum colistin A plus B concentration was 2.65 mg/liter after the loading dose (maximum time was 8 h). A significantly higher availability of the measured A and B forms of colistimethate and colistin explained the higher-than-expected concentrations in the present study compared to those in previous studies. Creatinine clearance was a time-varying covariate of colistimethate clearance. The incidence of acute renal injury was 20%. 相似文献
102.
Louiza Lioni Konstantinos P. Letsas Michael Efremidis Konstantinos Vlachos Georgios Giannopoulos Vasileios Kareliotis Spyridon Deftereos Antonios Sideris 《老年心脏病学杂志》2014,11(4):291-295
Background Atrial fibrillation (AF) catheter ablation has emerged as a promising treatment strategy for AF, but has not been widely adopted in the elderly population. The present study aimed to determine the safety and efficacy of AF catheter ablation in the elderly popula-tion. Methods and Results The study population consisted of 316 patients with paroxysmal AF who underwent left atrial ablation. Ninety-five patients were≥65 years (48 males, mean age 68.9 ± 3.0 years old) and 221 patients were〈65 years old (130 males, mean age 52.5 ± 10.4 years old). After a mean follow-up period of 34.0 ± 15.1 months, 55 (57.9%) patients in the elderly group were free from ar-rhythmia recurrence compared with 149 (67.4%) patients in the younger group (P=0.169). Procedural complications were uncommon in both study groups. In logistic regression analysis, left atrial diameter (P=0.003), hypertension (P=0.001), dyslipidemia (P=0.039), and coronary artery disease (P=0.018) were independent predictors of AF recurrence in the elderly population. Conclusions Catheter ablation of AF is safe and effective in older patients. Invasive strategies should be considered as an alternative choice in symptomatic elderly patients with AF. 相似文献
103.
104.
Malignant mesothelioma cells secrete natriuretic peptides: Data and diagnostic clinical implications
105.
106.
Maria Drakopoulou George Oikonomou Stergios Soulaidopoulos Basil Thanopoulos Konstantina Aggeli Dimitrios Tousoulis Konstantinos Toutouzas 《Congenital heart disease》2020,15(3):147-151
The percutaneous closure of ostium secundum atrial septal defects
(ASD) is a well-established procedure. Currently available devices and delivery
systems are designed to be used via the femoral venous route. However, an
alternative approach needs to be considered in cases of congenital or acquired
caval obstruction. We describe a successful transjugular closure of a moderate
sized secundum ASD with the Cocoon Septal Occluder in a 37-year-old
symptomatic woman with inferior vena cava (IVC) thrombosis, using a novel
deployment technique to overcome difficulties, namely maintaining stable sheath
position in the left atrium. Percutaneous closure of secundum ASDs via the
transjugular approach is safe, feasible and effective and can be a reasonable
alternative to surgical closure in patients with failed femoral venous access and
not anatomically complex atrial septal defects. 相似文献
107.
108.
Eleni Koraki Ioannis Mantzoros Christos Chatzakis Anna Gkiouliava Angeliki Cheva Athina Lavrentieva Freideriki Sifaki Helena Argiriadou Isaak Kesisoglou Konstantinos Galanos-Demiris Stefanos Bitsianis Konstantinos Tsalis 《World journal of hepatology》2020,12(11):1098-1114
BACKGROUNDHepatectomy with inflow occlusion results in ischemia-reperfusion injury; however, pharmacological preconditioning can prevent such injury and optimize the postoperative recovery of hepatectomized patients. The normal inflammatory response after a hepatectomy involves increased expression of metalloproteinases, which may signal pathologic hepatic tissue reformation. AIMTo investigate the effect of desflurane preconditioning on these inflammatory indices in patients with inflow occlusion undergoing hepatectomy.METHODSThis is a single-center, prospective, randomized controlled trial conducted at the 4th Department of Surgery of the Medical School of Aristotle University of Thessaloniki, between August 2016 and December 2017. Forty-six patients were randomized to either the desflurane treatment group for pharmacological preconditioning (by replacement of propofol with desflurane, administered 30 min before induction of ischemia) or the control group for standard intravenous propofol. The primary endpoint of expression levels of matrix metalloproteinases and their inhibitors was determined preoperatively and at 30 min posthepatic reperfusion. The secondary endpoints of neutrophil infiltration, coagulation profile, activity of antithrombin III (AT III), protein C (PC), protein S and biochemical markers of liver function were determined for 5 d postoperatively and compared between the groups.RESULTSThe desflurane treatment group showed significantly increased levels of tissue inhibitor of metalloproteinases 1 and 2, significantly decreased levels of matrix metalloproteinases 2 and 9, decreased neutrophil infiltration, and less profound changes in the coagulation profile. During the 5-d postoperative period, all patients showed significantly decreased activity of AT III, PC and protein S (vs baseline values, P < 0.05). The activity of AT III and PC differed significantly between the two groups from postoperative day 1 to postoperative day 5 (P < 0.05), showing a moderate drop in activity of AT III and PC in the desflurane treatment group and a dramatic drop in the control group. Compared to the control group, the desflurane treatment group also had significantly lower international normalized ratio values on all postoperative days (P < 0.005) and lower serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase values on postoperative days 2 and 3 (P < 0.05). Total length of stay was significantly less in the desflurane group (P = 0.009).CONCLUSIONDesflurane preconditioning can lessen the inflammatory response related to ischemia-reperfusion injury and may shorten length of hospitalization. 相似文献
109.