全文获取类型
收费全文 | 23094篇 |
免费 | 1182篇 |
国内免费 | 156篇 |
专业分类
耳鼻咽喉 | 187篇 |
儿科学 | 536篇 |
妇产科学 | 187篇 |
基础医学 | 3072篇 |
口腔科学 | 543篇 |
临床医学 | 1490篇 |
内科学 | 5990篇 |
皮肤病学 | 385篇 |
神经病学 | 2096篇 |
特种医学 | 844篇 |
外科学 | 3797篇 |
综合类 | 95篇 |
预防医学 | 684篇 |
眼科学 | 457篇 |
药学 | 1524篇 |
中国医学 | 56篇 |
肿瘤学 | 2489篇 |
出版年
2023年 | 134篇 |
2022年 | 224篇 |
2021年 | 479篇 |
2020年 | 238篇 |
2019年 | 371篇 |
2018年 | 499篇 |
2017年 | 403篇 |
2016年 | 488篇 |
2015年 | 527篇 |
2014年 | 632篇 |
2013年 | 814篇 |
2012年 | 1328篇 |
2011年 | 1498篇 |
2010年 | 824篇 |
2009年 | 694篇 |
2008年 | 1345篇 |
2007年 | 1529篇 |
2006年 | 1456篇 |
2005年 | 1550篇 |
2004年 | 1519篇 |
2003年 | 1474篇 |
2002年 | 1375篇 |
2001年 | 376篇 |
2000年 | 347篇 |
1999年 | 400篇 |
1998年 | 340篇 |
1997年 | 267篇 |
1996年 | 241篇 |
1995年 | 248篇 |
1994年 | 194篇 |
1993年 | 176篇 |
1992年 | 260篇 |
1991年 | 250篇 |
1990年 | 193篇 |
1989年 | 220篇 |
1988年 | 189篇 |
1987年 | 168篇 |
1986年 | 159篇 |
1985年 | 147篇 |
1984年 | 104篇 |
1983年 | 96篇 |
1982年 | 67篇 |
1981年 | 63篇 |
1980年 | 57篇 |
1979年 | 65篇 |
1978年 | 42篇 |
1974年 | 33篇 |
1971年 | 43篇 |
1970年 | 31篇 |
1969年 | 32篇 |
排序方式: 共有10000条查询结果,搜索用时 203 毫秒
951.
952.
Yusuke Okada Takashi Kato Kaori Iwata Yasuyuki Kimura Akinori Nakamura Hideyuki Hattori Hiroshi Toyama Kazunari Ishii Kenji Ishii Michio Senda Kengo Ito Takeshi Iwatsubo 《Annals of nuclear medicine》2020,34(2):108-118
The objectives of the present study were to investigate (1) whether trinary visual interpretation of amyloid positron emission tomography (PET) imaging (negative/equivocal/positive) reflects quantitative amyloid measurements and the time course of 11C-Pittsburgh compound B (PiB) amyloid accumulation, and (2) whether visually equivocal scans represent an early stage of the Alzheimer’s disease (AD) continuum in terms of an intermediate state of quantitative amyloid measurements and the changes in amyloid accumulation over time. From the National Bioscience Database Center Human Database of the Japanese Alzheimer’s Disease Neuroimaging Initiative, we selected 133 individuals for this study including 33 with Alzheimer’s disease dementia (ADD), 52 with late mild cognitive impairment (LMCI), and 48 cognitively normal (CN) subjects who underwent clinical assessment, PiB PET, and structural magnetic resonance imaging (MRI) with 2 or 3-years of follow-up. Sixty-eight of the 133 individuals underwent cerebrospinal fluid amyloid-β1-42 (CSF-Ab42) analysis at baseline. The standard uptake value ratio (SUVR) of PiB PET was calculated with a method using MRI at each visit. The cross-sectional values, longitudinal changes in SUVR, and baseline CSF-Ab42 were compared among groups, which were categorized based on trinary visual reads of amyloid PET (negative/equivocal/positive). From the trinary visual interpretation of the PiB PET images, 55 subjects were negative, 8 were equivocal, and 70 were positive. Negative interpretation was most frequent in the CN group (70.8/10.4/18.8%: negative/equivocal/positive), and positive was most frequent in the LMCI group (34.6/1.9/63.5%) and in the ADD group (9.1/6.1/84.8%). The baseline SUVRs were 1.08 ± 0.06 in the negative group, 1.23 ± 0.15 in the equivocal group, and 1.86 ± 0.31 in the positive group (F = 174.9, p < 0.001). The baseline CSF-Ab42 level was 463 ± 112 pg/mL in the negative group, 383 ± 125 pg/mL in the equivocal group, and 264 ± 69 pg/mL in the positive group (F = 37, p < 0.001). Over the 3-year follow-up, annual changes in SUVR were − 0.00 ± 0.02 in the negative group, 0.02 ± 0.02 in the equivocal group, and 0.04 ± 0.07 in the positive group (F = 8.4, p < 0.001). Trinary visual interpretation (negative/equivocal/positive) of amyloid PET imaging reflects quantitative amyloid measurements evaluated with PET and the CSF amyloid test as well as the amyloid accumulation over time evaluated with PET over 3 years. Subjects in the early stage of the AD continuum could be identified with an equivocal scan, because they showed intermediate quantitative amyloid PET, CSF measurements, and the amyloid accumulation over time. 相似文献
953.
Miwa Kenta Wagatsuma Kei Nemoto Reo Masubuchi Masaki Kamitaka Yuto Yamao Tensho Hiratsuka Seiya Yamaguchi Masashi Yoshii Tokiya Kobayashi Rinya Miyaji Noriaki Ishii Kenji 《Annals of nuclear medicine》2020,34(10):762-771
Annals of Nuclear Medicine - Many advances in PET/CT technology can potentially improve image quality and the ability to detect small lesions. A new digital TOF-PET/CT scanner based on silicon... 相似文献
954.
Satoshi Iyama Kazuyuki Murase Tsutomu Sato Akari Hashimoto Ayumi Tatekoshi Hiroto Horiguchi Yusuke Kamihara Kaoru Ono Shohei Kikuchi Kohichi Takada Yutaka Kawano Tsuyoshi Hayashi Koji Miyanishi Yasushi Sato Rishu Takimoto Masayoshi Kobune Satoru Mori Junji Kato Toshiharu Yamashita Junji Kato 《International journal of hematology》2014,99(4):471-476
Narrowband ultraviolet B phototherapy (NB-UVB) is a therapeutic alternative for haematopoietic stem cell transplantation-related skin graft-versus-host disease (GVHD). The beneficial effects of this intervention may be induced by direct irradiation of inflammatory cells in the skin; however, the putative involvement of indirect effects on systemic immunity has not been elucidated. To address this issue, 11 acute skin GVHD patients refractory to standard corticosteroid treatment and with no gut/liver involvement were treated with NB-UVB irradiation. The median number of treatments was 10 times, with a mean cumulative exposure of 6.36 J/cm2. No other immunosuppressive therapy was initiated during irradiation. Eight patients achieved an objective complete response, two had a partial response, and one showed no change. None of the patients experienced progressive skin GVHD or newly diagnosed gut/liver GVHD. NB-UVB was well tolerated, with no patients discontinuing irradiation due to toxicity. We additionally demonstrated by flow cytometry that NB-UVB irradiation induces the increment of the proportion of regulatory T cell (Tregs) in patients’ peripheral blood. These results suggest that NB-UVB may exert beneficial effects on steroid-refractory skin GVHD through the expansion of Tregs. 相似文献
955.
Akihito Fujimi Yusuke Kamihara Yuji Kanisawa Akari Hashimoto Chisa Nakajima Naotaka Hayasaka Naoki Uemura Toshinori Okuda Shinya Minami Satoshi Iyama Koichi Takada Tsutomu Sato Akinori Hara Yasunori Iwata Kengo Furuichi Takashi Wada Junji Kato 《International journal of hematology》2014,100(5):490-493
A 79-year-old female diagnosed with T cell/histiocyte-rich large B cell lymphoma in complete remission after six cycles of rituximab-combined chemotherapy developed severe anemia, reticulocytopenia, and bone marrow erythroid hypoplasia. She was diagnosed with pure red cell aplasia (PRCA) accompanied by Coombs-negative autoimmune hemolytic anemia evidenced by a lack of glycophorin-A-positive cells in the bone marrow, haptoglobin under the detection level, and a high titer of RBC-bound IgG. Anti-erythropoietin receptor (EPOR) antibody was detected in the serum, and oligoclonal α/β and γ/δ T cells were also detected in her peripheral blood by Southern blotting analysis. Parvovirus B19 DNA was not detected by PCR. Although the treatment with rituximab had limited efficacy (specifically, only for hemolysis), subsequent cyclosporine therapy led to prompt recovery of erythropoiesis with the disappearance of anti-EPOR antibody and oligoclonal T cells. This is the first case report of anti-EPOR antibody-associated PRCA in a patient with malignant lymphoma treated successfully with cyclosporine. 相似文献
956.
Kazunari Tominaga Mototsugu Kato Hiroshi Takeda Yasuyuki Shimoyama Eiji Umegaki Ryuichi Iwakiri Kenji Furuta Koichi Sakurai Takeo Odaka Hiroaki Kusunoki Akihito Nagahara Katsuhiko Iwakiri Takahisa Furuta Kazunari Murakami Hiroto Miwa Yoshikazu Kinoshita Ken Haruma Shin’ichi Takahashi Sumio Watanabe Kazuhide Higuchi Motoyasu Kusano Kazuma Fujimoto Tetsuo Arakawa G-PRIDE Study Group 《Journal of gastroenterology》2014,49(10):1392-1405
Background
The aim of this study was to investigate the efficacy of rikkunshito (RKT), a traditional Japanese medicine, combined with proton pump inhibitor (PPI) in patients with PPI-refractory non-erosive reflux disease (NERD).Methods
Patients with PPI-refractory NERD (n = 242) were randomly assigned to the RKT group [rabeprazole (10 mg/day) + RKT (7.5 g/t.i.d.) for 8 weeks] or the placebo group (rabeprazole + placebo). After the 4- and 8-week treatments, we assessed symptoms and quality of life (QOL) using the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease (FSSG), Gastrointestinal Symptom Rating Scale (GSRS), and Short-Form Health Survey-8 (SF-8).Results
There were no significant differences in FSSG and GSRS score improvement between these groups after the 4- and 8-week treatments. The mental component summary (MCS) scores of the SF-8 improved more in the RKT group (from 45.8 ± 8.1 to 48.5 ± 7.4) than in the placebo group (from 47.7 ± 7.1 to 48.4 ± 7.5) after the 4-week treatment (P < 0.05). The 8-week treatment with RKT was more effective for improvement of the degree of MCS score in patients with a low body mass index (<22) (P < 0.05) and significantly improved the acid-related dysmotility symptoms of FSSG in female and elderly patients (≥65 years).Conclusion
There were no significant differences in improvement of GERD symptoms in patients with PPI-refractory NERD between these groups. However, RKT may be useful for improving mental QOL in non-obese patients and acid-related dyspeptic symptoms, especially in women and the elderly. 相似文献957.
Kousuke Fukazawa Kenji Furuta Kyoichi Adachi Yoshiya Moritou Tsukasa Saito Ryusaku Kusunoki Goichi Uno Shino Shimura Masahito Aimi Shunji Ohara Shunji Ishihara Yoshikazu Kinoshita 《Journal of gastroenterology》2014,49(9):1307-1313
Background
The effects of the prokinetic drug mosapride on esophageal motor activity vary at standard doses. In addition to esophageal motor activities, compliance of the esophagogastric junction (EGJ) is important for prevention of gastroesophageal reflux. However, the effects of mosapride on EGJ compliance have not been reported. Here, we investigated the effects of high-dose mosapride on esophageal motor activities and EGJ compliance.Methods
Nine healthy volunteers were enrolled in the study. Peristaltic esophageal contraction and lower esophageal sphincter pressures before and after administration of 40 mg mosapride were examined by high resolution esophageal manometry. Esophageal compliance was also investigated by intra-esophageal impedance planimetry (EndoFLIP®).Results
High-dose mosapride augmented peristaltic contractions, especially in the distal esophageal segments (P < 0.05). The mean resting lower esophageal sphincter pressure was elevated from 25.0 mmHg before administration to 28.9 mmHg after (P < 0.05). In addition, mosapride significantly reduced EGJ compliance (P < 0.05).Conclusions
Mosapride at 40 mg augmented esophageal motor activities and reduced EGJ compliance in healthy volunteers. 相似文献958.
Terumi Kamisawa Kazuichi Okazaki Shigeyuki Kawa Tetsuhide Ito Kazuo Inui Hiroyuki Irie Takayoshi Nishino Kenji Notohara Isao Nishimori Shigeki Tanaka Toshimasa Nishiyama Koichi Suda Keiko Shiratori Masao Tanaka Tooru Shimosegawa 《Journal of gastroenterology》2014,49(6):961-970
The standard treatment for autoimmune pancreatitis (AIP) is steroid therapy, although some patients improve spontaneously. Indications for steroid therapy in AIP patients are symptoms such as obstructive jaundice, abdominal pain, back pain, and the presence of symptomatic extrapancreatic lesions. Prior to steroid therapy, obstructive jaundice should be managed by biliary drainage, and blood glucose levels should be controlled in patients with diabetes mellitus. The recommended initial oral prednisolone dose for induction of remission is 0.6 mg/kg/day, which is administered for 2–4 weeks. The dose is then tapered by 5 mg every 1–2 weeks, based on changes in clinical manifestations, biochemical blood tests (such as liver enzymes and IgG or IgG4 levels), and repeated imaging findings (US, CT, MRCP, ERCP, etc.). The dose is tapered to a maintenance dose (2.5–5 mg/day) over a period of 2–3 months. Cessation of steroid therapy should be based on the disease activity in each case. Termination of maintenance therapy should be planned within 3 years in cases with radiological and serological improvement. Re-administration or dose-up of steroid is effective for treating AIP relapse. Application of immunomodulatory drugs is considered for AIP patients who prove resistant to steroid therapy. The prognosis of AIP appears to be good over the short-term with steroid therapy. The long-term outcome is less clear, as there are many unknown factors, such as relapse, pancreatic exocrine or endocrine dysfunction, and associated malignancy. 相似文献
959.
Kazuichi Okazaki Shigeyuki Kawa Terumi Kamisawa Tetsuhide Ito Kazuo Inui Hiroyuki Irie Takayoshi Nishino Kenji Notohara Isao Nishimori Shigeki Tanaka Toshimasa Nishiyama Koichi Suda Keiko Shiratori Masao Tanaka Tooru Shimosegawa 《Journal of gastroenterology》2014,49(4):567-588
Background
In response to the proposal of the international consensus diagnostic criteria (ICDC) for autoimmune pancreatitis (AIP) and the Japanese diagnostic criteria in 2011, the 2009 Japanese consensus guidelines for managing AIP required revision.Methods
Three committees [the professional committee for making clinical questions (CQs) and statements by Japanese specialists, the expert panelist committee for rating statements by the modified Delphi method, and the evaluating committee by moderators] were organized. Fifteen specialists for AIP extracted the specific clinical statements from 1,843 articles published between 1963 and 2012 (obtained from Pub Med and a secondary database, and developed the CQs and statements. The expert panel individually rated the clinical statements using a modified Delphi approach, in which a clinical statement receiving a median score greater than seven on a nine-point scale from the panel was regarded as valid.Results
The professional committee created 13 CQs and statements for the current concept and diagnosis of AIP, 6 for extra-pancreatic lesions, 6 for differential diagnosis, and 11 for treatment.Conclusion
After evaluation by the moderators, amendments to the Japanese consensus guidelines for AIP have been proposed for 2013. 相似文献960.
Kentaro Konishi Tsuyoshi Minematsu Yasuhisa Nagasaka Kenji Tabata 《Biopharmaceutics & drug disposition》2019,40(5-6):176-187
We previously verified a physiologically based pharmacokinetic (PBPK) model for mirabegron in healthy subjects using the Simcyp Simulator by incorporating data on the inhibitory effect on cytochrome P450 (CYP) 2D6 and a multi‐elimination pathway mediated by CYP3A4, uridine 5′‐diphosphate‐glucuronosyltransferase (UGT) 2B7 and butyrylcholinesterase (BChE). The aim of this study was to use this PBPK model to assess the magnitude of drug–drug interactions (DDIs) in an elderly population with severe renal impairment (sRI), which has not been evaluated in clinical trials. We first determined the system parameters, and meta‐analyses of literature data suggested that the abundance of UGT2B7 and the BChE activity in an elderly population with sRI was almost equivalent to and 20% lower than that in healthy young subjects, respectively. Other parameters, such as the CYP3A4 abundance, for an sRI population were used according to those built into the Simcyp Simulator. Second, we confirmed that the PBPK model reproduced the plasma concentration–time profile for mirabegron in an sRI population (simulated area under the plasma concentration–time curve (AUC) was within 1.5‐times that of the observed value). Finally, we applied the PBPK model to simulate DDIs in an sRI population. The PBPK model predicted that the AUC for mirabegron with itraconazole (a CYP3A4 inhibitor) was 4.12‐times that in healthy elderly subjects administered mirabegron alone, and predicted that the proportional change in AUC for desipramine (a CYP2D6 substrate) with mirabegron was greater than that in healthy subjects. In conclusion, the PBPK model was verified for the purpose of DDI assessment in an elderly population with sRI. 相似文献