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OBJECTIVE: To ascertain the presence of myofibroblasts in sacs associated with inguinal hernia in children, through an ultrastructural evaluation using electron microscopy. MATERIALS AND METHODS: Sacs were obtained from 10 boys and 10 girls (of similar age, approximately 45 months) with inguinal hernia and processed for electron microscopy. Thin sections were examined specifically for the presence of myofibroblasts. RESULTS: The ultrastructural evaluation showed myofibroblasts with classical electron microscopic features within all of the sacs, regardless of the gender of origin. CONCLUSION: The persistence of smooth muscle hinders the obliteration of the processus vaginalis; myofibroblasts are found in association with smooth muscle and thus such cells within the sac walls seem to originate from the smooth muscle, reflecting the dedifferentiation of smooth muscle. This dedifferentiated state may represent attempted apoptosis, which usually causes the disappearance of the smooth muscle and obliteration of the processus vaginalis after the descent of the testis into the scrotum. 相似文献
74.
C Kaymaz N Ozdemir C Kirma I Akdemir M Ozkan 《European journal of echocardiography》2001,2(3):149-153
This report presents three patients with severe pulmonary hypertension secondary to atrial septal defect associated with thrombus and spontaneous echo contrast within the pulmonary artery diagnosed by transthoracic and transoesophageal echocardiography. Clinical and echocardiographic features seem to suggest local thrombus formation within the pulmonary arteries as a direct consequence of pulmonary hypertension rather than venous thromboembolism. 相似文献
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Ekim Z. Taskiran Emine Korkmaz Safak Gucer Can Kosukcu Figen Kaymaz Cansu Koyunlar Elizabeth C. Bryda Moumita Chaki Dongmei Lu Komal Vadnagara Cengiz Candan Rezan Topaloglu Franz Schaefer Massimo Attanasio Carsten Bergmann Fatih Ozaltin 《Journal of the American Society of Nephrology : JASN》2014,25(8):1653-1661
Nephronophthisis (NPHP) is one of the most common genetic causes of CKD; however, the underlying genetic abnormalities have been established in <50% of patients. We performed genome-wide analysis followed by targeted resequencing in a Turkish consanguineous multiplex family and identified a canonic splice site mutation in ANKS6 associated with an NPHP-like phenotype. Furthermore, we identified four additional ANKS6 variants in a cohort of 56 unrelated patients diagnosed with CKD due to nephronophthisis, chronic GN, interstitial nephritis, or unknown etiology. Immunohistochemistry in human embryonic kidney tissue demonstrated that the expression patterns of ANKS6 change substantially during development. Furthermore, we detected increased levels of both total and active β-catenin in precystic tubuli in Han:SPRD Cy/+ rats. Overall, these data indicate the importance of ANKS6 in human kidney development and suggest a mechanism by which mutations in ANKS6 may contribute to an NPHP-like phenotype in humans. 相似文献
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Gastric adenocarcinoma: CT versus surgical staging 总被引:19,自引:0,他引:19
Sussman SK; Halvorsen RA Jr; Illescas FF; Cohan RH; Saeed M; Silverman PM; Thompson WM; Meyers WC 《Radiology》1988,167(2):335-340
Seventy-five patients with gastric carcinoma underwent preoperative staging with computed tomography (CT). In 14 patients, CT failed to demonstrate lymphadenopathy despite the presence of malignant lymph nodes at surgery. In 13 patients, CT demonstrated enlarged nodes, but no malignant involvement was found at surgery. Although spread to the pancreas was correctly predicted in three patients with lack of fat plane between tumor and pancreas, five patients lacking a fat plane had no invasion, whereas eight patients with an intact fat plane had invasion. Thirty-five patients (47%) were incorrectly staged with CT:23 (31%) were understaged and 12 (16%) were overstaged. CT does not accurately display the true extent of disease in patients with gastric carcinoma and therefore should not be used routinely for staging. 相似文献
79.
Fatma Dedeoglu Hulya Kaymaz Norma Seaver Samuel F. Schluter David E. Yocurn John J. Marchalonis 《Immunologic research》1993,12(1):12-20
The T-cell receptor Vβ subfamily repertoires of synovial and peripheral T cells of 8 rheumatoid arthritis (RA) patients were
determined using the polymerase chain reaction. Three normal controls were included. Some of the rheumatoid synovial samples
did not express the complete range of Vβ families and lacked as many as 6 gene families. However, these patients showed considerable
individual variation in expression. Overall, the data do not support preferential T-cell receptor Vβ usage in synovial T cells
of RA patients either in comparison to their autochthonous peripheral T cells or to peripheral T cells of normal subjects. 相似文献
80.
Percutaneous dilation of benign biliary strictures 总被引:1,自引:0,他引:1
Moore AV Jr; Illescas FF; Mills SR; Wertman DE; Heaston DK; Newman GE; Zuger JH; Salmon RB; Dunnick NR 《Radiology》1987,163(3):625-628
Percutaneous balloon dilation of benign biliary strictures was successful in 15 of 18 patients in whom the procedure was attempted. Successful dilation was achieved in nine of 11 patients who had biliary enteric strictures, with follow-up of 22-55 months (mean, 35.4 months) after catheter removal in seven patients. Five of six strictures in the biliary tree that developed after surgery were successfully dilated, with long-term follow-up available in two patients (58 and 42 months). A patient with an inflammatory common bile duct stricture that was successfully dilated was followed up for 18 months. Percutaneous dilation of biliary tract strictures is a promising technique with good long-term results and may be the initial treatment of choice in biliary stricture management. 相似文献