全文获取类型
收费全文 | 4026篇 |
免费 | 147篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 83篇 |
儿科学 | 52篇 |
妇产科学 | 40篇 |
基础医学 | 450篇 |
口腔科学 | 55篇 |
临床医学 | 218篇 |
内科学 | 1056篇 |
皮肤病学 | 33篇 |
神经病学 | 298篇 |
特种医学 | 119篇 |
外科学 | 777篇 |
综合类 | 23篇 |
预防医学 | 126篇 |
眼科学 | 155篇 |
药学 | 306篇 |
中国医学 | 14篇 |
肿瘤学 | 385篇 |
出版年
2022年 | 34篇 |
2021年 | 66篇 |
2020年 | 28篇 |
2019年 | 45篇 |
2018年 | 57篇 |
2017年 | 66篇 |
2016年 | 71篇 |
2015年 | 58篇 |
2014年 | 69篇 |
2013年 | 99篇 |
2012年 | 155篇 |
2011年 | 163篇 |
2010年 | 128篇 |
2009年 | 80篇 |
2008年 | 211篇 |
2007年 | 180篇 |
2006年 | 174篇 |
2005年 | 196篇 |
2004年 | 180篇 |
2003年 | 225篇 |
2002年 | 201篇 |
2001年 | 137篇 |
2000年 | 146篇 |
1999年 | 147篇 |
1998年 | 68篇 |
1997年 | 37篇 |
1996年 | 30篇 |
1995年 | 31篇 |
1994年 | 28篇 |
1993年 | 23篇 |
1992年 | 85篇 |
1991年 | 60篇 |
1990年 | 77篇 |
1989年 | 81篇 |
1988年 | 62篇 |
1987年 | 53篇 |
1986年 | 64篇 |
1985年 | 46篇 |
1984年 | 41篇 |
1983年 | 31篇 |
1979年 | 27篇 |
1975年 | 22篇 |
1974年 | 23篇 |
1973年 | 36篇 |
1971年 | 21篇 |
1970年 | 26篇 |
1969年 | 33篇 |
1968年 | 34篇 |
1967年 | 31篇 |
1966年 | 22篇 |
排序方式: 共有4190条查询结果,搜索用时 31 毫秒
71.
72.
73.
Fujii Y Yoshida M Chien LJ Kihara K Kageyama Y Yasukochi Y Oshima H 《Urologia internationalis》2000,64(3):129-133
OBJECTIVE: To assess the contribution of the carbohydrate antigens, sialyl-Lewis X (sLe(x)) and sialyl-Lewis A (sLe(a)), which are known to be ligands for E-selectin, to the adhesion between human urothelial cancer cells and cytokine-activated human endothelial cells. MATERIALS AND METHODS: We studied the expression of sLe(x) and sLe(a) antigens of three bladder cancer cell lines (JTC 30, JTC 32, and T24) by flow cytometry and the adherence to interleukin 1beta-activated human umbilical vein endothelial cells (HUVEC). RESULTS: JTC 30 and JTC 32 cells expressed both sLe(x) and sLe(a) antigens, and showed adhesion to activated HUVEC, which was completely abolished by anti-E-selectin antibody. T24 cells expressed neither sLe(x) nor sLe(a) antigen, and did not adhere to activated HUVEC. Each of anti-sLe(a) or anti-sLe(x) antibody partially blocked the attachment of JTC 30 cells to activated HUVEC, and combination of these antibodies almost completely blocked the adhesion. The combination of antibodies did not significantly influence the adhesion of JTC 32 cells. CONCLUSION: These results indicate that both sLe(a) and sLe(x) carbohydrate antigens are involved in E-selectin-mediated adhesion of some urothelial cancers, and that there might be unknown ligands for E-selectin on urothelial cancer cells. 相似文献
74.
Hideaki Suzuki Akira Shimomura Katsuhisa Ikeda Masayuki Furukawa Takeshi Oshima Tomonori Takasaka 《The Laryngoscope》1997,107(12):1661-1666
The mechanism of macrolide therapy in chronic sinusitis patients is unclear. The authors studied the effect of macrolides on interleukin (IL)-8 secretion from cultured human nasal epithelial cells. Epithelial cells harvested from the nasal polyps of patients with chronic sinusitis were primary-cultured, and secreted IL-8 in culture media was measured by enzyme immunoassay. The cells secreted considerable amounts of IL-8 constitutively and in response to lipopolysaccharide. The secretion was significantly inhibited by 10?5 M of erythromycin, clarithromycin, roxithromycin, and josamycin. 10?6 M erythromycin still showed the inhibitory effect, whereas the same concentration of josamycin did not. These results indicate that macrolide antibiotics may act as an immunomodulator to reduce IL-8 in inflammatory sites and, at least partially, account for the clinically discrepant effects between 14- and 16-membered ring macrolides in long-term low-dose therapy for chronic sinusitis. 相似文献
75.
A. Oshima W. Ajiki H. Tanaka H. Tsukuma 《International journal of clinical oncology / Japan Society of Clinical Oncology》1998,3(6):343-350
A cancer registry is an organization set up for the collection, storage, analysis, and interpretation of data on people with cancer. There are three types of cancer registry: hospital-based, population-based, and nationwide site-specific. A cancer registry is essential for planning and evaluating cancer control activities, including clinical practices. We describe the significance and usefulness of cancer registries, with examples of assessments of the size of the cancer problem (i.e., incidence, mortality rates, and survival of cancer patients), assessments of the effects of cancer control programs, feedback to clinicians, and the building and testing of hypotheses of cancer etiology. 相似文献
76.
Nagata T Matsuyama M Kiriike N Iketani T Oshima J 《The Journal of nervous and mental disease》2000,188(5):280-286
Although maladaptive coping strategies in eating disorder patients have been reported, the relationship between impulsivity and coping strategy has not previously been studied. Subjects consisted of 43 patients with anorexia nervosa restricting type (AN-R), 42 patients with anorexia nervosa binge eating/purging type (AN-BP), 71 patients with bulimia nervosa purging type (BN), and 97 controls. The Coping Inventory for Stressful Situations was used to evaluate coping strategies. Only AN-BP patients had a significantly lower task oriented-coping score than controls, and AN-R and BN patient groups used significantly less social diversion-avoidance coping strategies than controls. Emotion-oriented coping scores of AN-BP and BN patients were significantly higher than those of controls. In addition, impulsive BN patients had significantly higher emotional coping scores than less impulsive BN patients. These results suggest that maladaptive coping strategies may be a perpetuating factor even for impulsive patients and emphasizing a change in maladaptive coping strategies may be a useful treatment strategy even for highly impulsive patients. 相似文献
77.
78.
79.
80.
Koichi Hiraoka Kyudo Igawa Mina Kashiwagi Chisato Nakahara Yuki Oshima Yu Takakura 《Laterality》2018,23(1):51-66
The objective of the present study was to investigate whether the stop and go processes of the motor response are asymmetrical and whether the asymmetries are dependent on handedness and the response selection process that is engaged. Both right-handed and left-handed participants abducted either the left or right index finger in response to an imperative cue in the choice reaction time (choice RT) or the simple RT task. A stop cue was presented after the imperative cue with a probability of .25. When the stop cue was presented, the participants withheld the prepared response. On the choice RT task, left-handed participants had significantly shorter RT and stop signal reaction time (SSRT) with the left versus the right hand, whereas right-handers showed no difference between hands on either measure. In the simple RT task, the RT and SSRT were not significantly different between the groups or the response sides. These results indicate that both the stop and go processes of the prepared left-hand response are completed earlier than those of the right-hand response in left-handed individuals when the stimulus-response process involves a response selection process. 相似文献