The usefulness of elemental iron for cereal flour fortification: a SUSTAIN Task Force report. Sharing United States Technology to Aid in the Improvement of Nutrition

Fortification of cereal flours may be a useful public health strategy to combat iron deficiency. Cereal flours that are used shortly after production (e.g., baking flour) can be fortified with soluble iron compounds, such as ferrous sulfate, whereas the majority of flours stored for longer periods is usually fortified with elemental iron powders to avoid unacceptable sensory changes. Elemental iron powders are less well absorbed than soluble iron compounds and they vary widely in their absorption depending on manufacturing method and physicochemical characteristics. Costs vary with powder type, but elemental iron powders are generally less expensive than ferrous sulfate. This review evaluates the usefulness of the different elemental iron powders based on results from in vitro studies, rat assays, human bioavailability studies, and efficacy studies monitoring iron status in human subjects. It concludes that, at the present time, only electrolytic iron powder can be recommended as an iron fortificant. Because it is only approximately half as well absorbed as ferrous sulfate, it should be added to provide double the amount of iron.     

Profile of undergraduate nursing students' attitudes towards mental disease,before the influence of specific academic education

Students starting the Nursing Course bring with them stereotypes and prejudice in relation to mentally-ill people, thus showing lack of knowledge as to their possibilities of recovery and social living. This study aimed at elaborating a profile of the attitudes presented by these students in relation to such people and at showing aspects that can negatively influence their future professional conduct. To that end, the opinion scale for mental disease was used. The students presented a negative attitude profile, which made it possible to conclude that academic education from courses in this area must be planned so as to favor the change of the attitude profile presented.     

Drug and alcohol-related emergency department visits: results of a pilot survey in two hospitals in Israel

There is no system for reporting drug and alcohol-related emergency department (ED) visits in Israel. This pilot survey was aimed at examining the feasibility of establishing an ED surveillance system in a general hospital and a psychiatric hospital. We describe the design and preliminary results of a pilot-survey conducted in the emergency departments of two hospitals in Northern Israel. Active and passive case identification was conducted in Rambam Hospital and Tirat Carmel Psychiatric Hospital, from August, 1999-January, 2000. A total of 160 ED patients were identified, 64% as drug-related, with heroin being the most common drug. The majority of cases were identified through self-reports. Overdose and IVDU complications accounted for 20% of drug cases identified at Rambam Hospital, and injury and motor vehicle accidents accounted for 12% of all visits at this hospital. We did not attempt to estimate the proportion of all ED visits that are associated with drugs and/or alcohol. Under-ascertainment of cases and incomplete data recording remain major concerns for a survey of this nature. Results of this pilot survey indicate that with proper training of ED nurses a national ED surveillance system can be successfully and efficiently established in general hospitals and psychiatric hospitals in Israel.     

Late lower extremity fractures in patients with paraplegia

We report the result of the treatment of 26 lower limb fractures in patients with established paraplegia. We treated one fracture of the femoral neck, one intertrochanteric, two subtrochanteric, two of the femoral shaft, seven of the supracondylar region, six of the proximal tibia, one of the tibial shaft, and six pilon fractures. Nine fractures were treated non-operatively, and the remaining fractures were treated operatively. Union was achieved in all the patients, but we think that open reduction and internal fixation may improve the level of independence and mobility of these patients during fracture healing.     

Orthomolecular oncology: a mechanistic view of intravenous ascorbate's chemotherapeutic activity

The effect of vitamin C in cancer has been a subject of great controversy; mainly because of the inconsistent results obtained by oral intakes of ascorbate when used as an anticancer agent. We believe the intravenous application of ascorbate will provide more consistent results in cancer patients since Vitamin C blood levels attained are substantially higher in a range proven cytotoxic to malignant cells. In this article we will present and discuss our proposed mechanism on the chemotherapeutic activity exhibited by ascorbate.     

Tumor lysis syndrome in extensive-stage small-cell lung cancer

Tumor lysis syndrome is a constellation of metabolic complications that occurs in the setting of treatment of hematologic malignancies. On occasion, it has been reported to occur after therapy for solid tumors associated with large tumor burdens and aggressive therapy. We herein report the rare occurrence of acute tumor lysis syndrome in a woman with extensive-stage small-cell lung cancer after cytotoxic therapy.     

Raltitrexed (Tomudex): an alternative choice in patients intolerant to 5-fluorouracil

Raltitrexed (Tomudex), a classical folate antagonist, is a selective inhibitor of thymidylate synthase (TS). It has significant single-agent activity in metastatic colorectal cancer. Severe life-threatening toxicity related to the administration of 5-fluorouracil and leucovorin is described in two patients, both of whom were not deficient in dihydropyrimidine dehydrogenase. Raltitrexed was administered to both patients with clinically acceptable side effects and allowed a TS inhibitor to be administered as part of an adjuvant program.