全文获取类型
收费全文 | 59937篇 |
免费 | 3837篇 |
国内免费 | 209篇 |
专业分类
耳鼻咽喉 | 847篇 |
儿科学 | 1349篇 |
妇产科学 | 1199篇 |
基础医学 | 7233篇 |
口腔科学 | 9862篇 |
临床医学 | 4408篇 |
内科学 | 11923篇 |
皮肤病学 | 1463篇 |
神经病学 | 4848篇 |
特种医学 | 1224篇 |
外国民族医学 | 1篇 |
外科学 | 6506篇 |
综合类 | 301篇 |
一般理论 | 15篇 |
预防医学 | 5211篇 |
眼科学 | 1086篇 |
药学 | 3833篇 |
中国医学 | 372篇 |
肿瘤学 | 2302篇 |
出版年
2023年 | 747篇 |
2022年 | 948篇 |
2021年 | 1805篇 |
2020年 | 1113篇 |
2019年 | 1610篇 |
2018年 | 2141篇 |
2017年 | 1628篇 |
2016年 | 1752篇 |
2015年 | 2043篇 |
2014年 | 2593篇 |
2013年 | 3183篇 |
2012年 | 4330篇 |
2011年 | 4590篇 |
2010年 | 2620篇 |
2009年 | 2391篇 |
2008年 | 3482篇 |
2007年 | 3445篇 |
2006年 | 3116篇 |
2005年 | 2890篇 |
2004年 | 2720篇 |
2003年 | 2356篇 |
2002年 | 2181篇 |
2001年 | 1225篇 |
2000年 | 1192篇 |
1999年 | 983篇 |
1998年 | 566篇 |
1997年 | 440篇 |
1996年 | 431篇 |
1995年 | 347篇 |
1994年 | 324篇 |
1993年 | 254篇 |
1992年 | 457篇 |
1991年 | 411篇 |
1990年 | 379篇 |
1989年 | 271篇 |
1988年 | 302篇 |
1987年 | 285篇 |
1986年 | 227篇 |
1985年 | 229篇 |
1984年 | 220篇 |
1983年 | 188篇 |
1982年 | 121篇 |
1981年 | 122篇 |
1980年 | 86篇 |
1979年 | 116篇 |
1978年 | 92篇 |
1975年 | 84篇 |
1971年 | 73篇 |
1969年 | 74篇 |
1967年 | 88篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
Bulimia is a distinct diagnostic eating disorder with its most noted manifestation being the rapid ingestion of large quantities of food followed by its elimination through the mouth. Because of the dental implications of highly acidic stomach contents chronically being regurgitated, the dentist is in a unique position to help identify the patient with bulimia. Dental erosion is not only the most easily noted but also the most destructive of the many oral problems caused by bulimia. This report of case describes a preventive dental prosthesis that can be used by the patient with bulimia to protect those teeth that are most affected by dental erosion. The construction of the prosthesis is easily completed with materials in the dental office and provides a great service to the patient with bulimia. 相似文献
22.
23.
Pascale Jolliet Stéphane Nion Gwena?lle Allain-Veyrac L Tilloy-Fenart Dorothée Vanuxeem Vincent Berezowski Roméo Cecchelli 《Pharmacological research》2007,56(1):11-17
PURPOSE: The objective of the current study was to determine the ability of some antiemetic compounds to cross the blood-brain barrier (BBB) and thereby to determine possible side effects of compounds for the central nervous system (CNS). METHODS: We compared the brain penetration of some antiemetic compounds using an in vitro BBB model consisting in brain capillary endothelial cells co-cultured with primary rat glial cells. RESULTS: This study clearly demonstrated that the metopimazine metabolite, metopimazine acid, has a very low brain penetration, lower than metopimazine and even less than the other antiemetic compounds tested in this study. CONCLUSIONS: The poor brain penetration of metopimazine acid, metopimazine biodisponible form, seems very likely related to the clinically observed difference in therapeutic and safety profile. 相似文献
24.
E. Wieczerzak E. Jankowska S. Rodziewicz‐Motowido A. Giedo J. giewka Z. Grzonka M. Abrahamson A. Grubb D. Brmme 《Chemical biology & drug design》2005,66(Z1):1-11
Abstract: We have designed and synthesized a new series of azapeptides which act as potential inhibitors of cathepsin B and/or cathepsin K. Their structures are based upon the inhibitory sites of natural cysteine protease inhibitors, cystatins. For the synthesized azapeptides, the equilibrium constants for dissociation of inhibitor–enzyme complex, Ki, were determined. Comparison of these values indicated that all of the azainhibitors act much stronger toward cathepsin B. Z‐Arg‐Leu‐His‐Agly‐Ile‐Val‐OMe ( 7 ) proved to be approximately 500 times more potent for cathepsin B than for cathepsin K. To be able to explain the obtained experimental values we used the molecular dynamics procedures to analyze the interactions between cathepsin B and compound 7 . We also determined the structure of the most potent and selective cathepsin B azainhibitor by means of NMR studies and theoretical calculations. In this report, we describe SAR studies of azapeptide inhibitors indicating the influence of the conformational flexibility of the examined compounds on inhibition of cathepsins B and K. 相似文献
25.
Lesley B Milgrom Jo Ann Brooks Rong Qi Karen Bunnell Susie Wuestfeld Daniel Beckman 《American journal of critical care》2004,13(2):116-125
BACKGROUND: Acute pain is common after cardiac surgery and can keep patients from participating in activities that prevent postoperative complications. Accurate assessment and understanding of pain are vital for providing satisfactory pain control and optimizing recovery. OBJECTIVES: To describe pain levels for 5 activities expected of patients after cardiac surgery on postoperative days 1 to 6 and changes in pain levels after chest tube removal and extubation. METHODS: Adults who underwent cardiac surgery were asked to rate the pain associated with various types of activities on postoperative days 1 to 6. Pain levels were compared by postoperative day, activity, and type of cardiac surgery. Pain scores before and after chest tube removal and extubation also were analyzed. RESULTS: Pain scores were higher on earlier postoperative days. The order of overall pain scores among activities (P < .01) from highest to lowest was coughing, moving or turning in bed, getting up, deep breathing or using the incentive spirometer, and resting. Changes in pain reported with coughing (P = .03) and deep breathing or using the incentive spirometer (P = .005) differed significantly over time between surgery groups. After chest tubes were discontinued, patients had lower pain levels at rest (P = .01), with coughing (P = .05), and when getting up (P = .03). CONCLUSIONS: Pain relief is an important outcome of care. A comprehensive, individualized assessment of pain that incorporates activity levels is necessary to promote satisfactory management of pain. 相似文献
26.
Background
Reports on childhood cancer survivors estimated cumulative probability of developing secondary neoplasms vary from 3,3% to 25% at 25 years from diagnosis, and the risk of developing another cancer to several times greater than in the general population. 相似文献27.
Alcides José Branco Filho William Kondo Luis Sérgio Nassif Mariana Jorge Garcia Rafael de Almeida Tirapelle Carlos Marcelo Dotti 《JSLS, Journal of the Society of Laparoendoscopic Surgeons》2006,10(3):326-331
BACKGROUND: Gastrogastric fistula is a communication between the proximal gastric pouch and the distal gastric remnant, rarely described in the realm of bariatric procedures. The aim of this study was to review the existing literature about this topic and to demonstrate its laparoscopic treatment. METHODS: An extensive literature review found several articles reporting this complication. However, no citation was found describing the steps of the laparoscopic management of this situation. RESULTS: Gastrogastric fistula occurs in up to 6% of Roux-en-Y gastric bypasses. Two theories exist for fistula formation: (1) it is a technical complication derived from the incomplete division of the stomach during the creation of the pouch, and (2) it occurs after a staple-line failure, developing a leak with an abscess, which then drains into the distal stomach forming the fistula. Early symptoms include fever, tachycardia, and abdominal pain. Failure in weight loss is a late clinical sign observed in these patients. Diagnosis is based on radiologic study, upper endoscopy and computed tomography. When identified in the acute postoperative course, laparoscopic treatment is easy. Chronic fistulas are difficult to manage, and the laparoscopic approach is an alternative to open surgery. CONCLUSIONS: Gastrogastric fistula is a possible complication of Roux-en-Y gastric bypass and its laparoscopic treatment is feasible. 相似文献
28.
29.
30.
Sérgio Carreir?o Leandro Pereira Marcelo Wilson Rocha Almeida 《Aesthetic plastic surgery》2009,33(3):445-451
Surgical procedures for the mammary region currently are assuming an important role in body-contouring surgery. Enhancement
of results is a constant challenge to the plastic surgeon. A simple and efficient maneuver for resection of the breast’s lateral
pole based on the mammoplasty technique of Professor Ivo Pitanguy is described.
This study realized at the Private Clinic Sérgio Carreir?o, Rio de Janeiro, RJ, Brazil. 相似文献