全文获取类型
收费全文 | 200900篇 |
免费 | 52072篇 |
国内免费 | 5029篇 |
专业分类
耳鼻咽喉 | 3338篇 |
儿科学 | 5734篇 |
妇产科学 | 2155篇 |
基础医学 | 33602篇 |
口腔科学 | 7545篇 |
临床医学 | 25196篇 |
内科学 | 42202篇 |
皮肤病学 | 10298篇 |
神经病学 | 20486篇 |
特种医学 | 8667篇 |
外国民族医学 | 21篇 |
外科学 | 28382篇 |
综合类 | 12306篇 |
现状与发展 | 30篇 |
一般理论 | 45篇 |
预防医学 | 11944篇 |
眼科学 | 4849篇 |
药学 | 18458篇 |
66篇 | |
中国医学 | 5339篇 |
肿瘤学 | 17338篇 |
出版年
2024年 | 169篇 |
2023年 | 1129篇 |
2022年 | 3063篇 |
2021年 | 6497篇 |
2020年 | 8073篇 |
2019年 | 13606篇 |
2018年 | 13535篇 |
2017年 | 14265篇 |
2016年 | 15459篇 |
2015年 | 17224篇 |
2014年 | 18430篇 |
2013年 | 19257篇 |
2012年 | 15304篇 |
2011年 | 15171篇 |
2010年 | 15517篇 |
2009年 | 11138篇 |
2008年 | 10118篇 |
2007年 | 8477篇 |
2006年 | 7853篇 |
2005年 | 6861篇 |
2004年 | 5620篇 |
2003年 | 5340篇 |
2002年 | 4708篇 |
2001年 | 3948篇 |
2000年 | 3452篇 |
1999年 | 2499篇 |
1998年 | 1217篇 |
1997年 | 992篇 |
1996年 | 864篇 |
1995年 | 757篇 |
1994年 | 704篇 |
1993年 | 511篇 |
1992年 | 797篇 |
1991年 | 761篇 |
1990年 | 648篇 |
1989年 | 583篇 |
1988年 | 486篇 |
1987年 | 523篇 |
1986年 | 376篇 |
1985年 | 320篇 |
1984年 | 211篇 |
1983年 | 184篇 |
1982年 | 118篇 |
1981年 | 106篇 |
1980年 | 82篇 |
1979年 | 119篇 |
1978年 | 111篇 |
1975年 | 68篇 |
1974年 | 76篇 |
1973年 | 68篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
92.
随着腔镜技术的进一步发展以及微创理念应用于结直肠外科疾病的诊治中,结直肠相关疾病的诊治发生了翻天覆地的变化。由传统的经腹手术到腹腔镜手术、经自然腔道手术,再到经自然腔道取标本手术(NOSES),结直肠疾病的外科诊治在微创领域取得了巨大成果。NOSES技术是目前结直肠外科在微创领域前沿的手术方式之一,它通过经直肠、阴道取标本来避免了腹壁的辅助取标本切口,从而将结直肠外科手术进一步微创化。NOSES技术集传统腹腔镜手术的优势与现代微创外科的理念于一体,它在确保手术效果的基础上集中体现了微创、加速康复外科、功能外科、"无疤"等理念的特点。本文主要就国内外各中心开展NOSES技术在结直肠外科诊治开展中的相关经验、心得和体会进行综述。 相似文献
93.
PNPLA3 gene polymorphism and response to lifestyle modification in patients with nonalcoholic fatty liver disease
下载免费PDF全文
![点击此处可从《Journal of gastroenterology and hepatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
94.
Iria Montero Prez Laura Rodríguez‐Pazos Adriana lvarez‐Prez MªMercedes Pereiro Ferreirs Carlos Aliste Jose Manuel Suarez‐Pearanda Jaime Toribio 《Journal of cutaneous pathology》2015,42(11):889-893
Classical Kaposi sarcoma (KS) usually appears on lower extremities accompanied or preceded by local lymphedema. However, the development in areas of chronic lymphedema of the arms following mastectomy, mimicking a Stewart–Treves syndrome, has rarely been described. We report an 81‐year‐old woman who developed multiple, erythematous to purple tumors, located on areas of post mastectomy lymphedema. Histopathological examination evidenced several dermal nodules formed by spindle‐shaped cells that delimitated slit‐like vascular spaces with some red cell extravasation. Immunohistochemically, the human herpesvirus type 8 (HHV‐8) latent nuclear antigen‐1 was detected in the nuclei of most tumoral cells confirming the diagnosis of KS. Lymphedema could promote the development of certain tumors by altering immunocompetence. Although angiosarcoma (AS) is the most frequent neoplasia arising in the setting of chronic lymphedema, other tumors such as benign lymphangiomatous papules (BLAP) or KS can also develop in lymphedematous limbs. It is important to establish the difference between AS and KS because their prognosis and treatment are very different. Identification by immunohistochemistry of HHV‐8 is useful for the distinction between KS and AS or BLAP. 相似文献
95.
Tien‐Yao Tsai Iat‐Lon Leong Ka‐Shun Cheng Lian‐Ru Shiao Tzu‐Hui Su Kar‐Lok Wong Paul Chan Yuk‐Man Leung 《Fundamental & clinical pharmacology》2019,33(1):52-62
A pathological feature in atherosclerosis is the dysfunction and death of vascular endothelial cells (EC). Oxidized low‐density lipoprotein (LDL), known to accumulate in the atherosclerotic arterial walls, impairs endothelium‐dependent relaxation and causes EC apoptosis. A major bioactive ingredient of the oxidized LDL is lysophosphatidylcholine (LPC), which at higher concentrations causes apoptosis and necrosis in various EC. There is hitherto no report on LPC‐induced cytotoxicity in brain EC. In this work, we found that LPC caused cytosolic Ca2+ overload, mitochondrial membrane potential decrease, p38 activation, caspase 3 activation and eventually apoptotic death in mouse cerebral bEND.3 EC. In contrast to reported reactive oxygen species (ROS) generation by LPC in other EC, LPC did not trigger ROS formation in bEND.3 cells. Pharmacological inhibition of p38 alleviated LPC‐inflicted cell death. We examined whether heparin could be cytoprotective: although it could not suppress LPC‐triggered Ca2+ signal, p38 activation and mitochondrial membrane potential drop, it did suppress LPC‐induced caspase 3 activation and alleviate LPC‐inflicted cytotoxicity. Our data suggest LPC apoptotic death mechanisms in bEND.3 might involve mitochondrial membrane potential decrease and p38 activation. Heparin is protective against LPC cytotoxicity and might intervene steps between mitochondrial membrane potential drop/p38 activation and caspase 3 activation. 相似文献
96.
M.‐Q. Man L. Ye L. Hu S. Jeong P. M. Elias C. Lv 《Clinical and experimental dermatology》2019,44(6):654-657
While therapeutic approaches for psoriasis are widely available, preventive regimens are lacking. We aimed to determine whether improvements in epidermal function could prevent psoriasis relapse. Two self‐controlled cohort studies were designed, enrolling two cohorts of patients with psoriasis (n = 30 and n = 60) to be treated topically with an in‐house‐prepared emollient or ATOPALM® cream applied twice daily to one forearm for 20 and 30 days, respectively, while the same sites on the contralateral arm served as the untreated control. Epidermal function on both arms was assessed prior to and at the end of the trials. Delayed relapse on the treated arm was seen in 54.5% and 71% of patients in the first and second cohort, respectively. The time of psoriatic relapse correlated with the extent of abnormalities in baseline epidermal function. These results suggest that improvements in epidermal function with topical emollients can prevent/attenuate the development of psoriasis. 相似文献
97.
98.
99.
100.
Luis Veloza Cristina Teixido Natalia Castrejon Fina Climent Ana Carri Marta Marginet Davide Soldini Blanca Gonzlez‐Farr Inmaculada Ribera‐Cortada Armando Lopez‐Guillermo Eva Gonzlez‐Barca Adriana Sierra Mileyka Herrera Cndida Gmez Adriana Garcia Olga Balagu Elias Campo Antonio Martinez 《Histopathology》2019,75(6):799-812