全文获取类型
收费全文 | 219281篇 |
免费 | 52018篇 |
国内免费 | 3254篇 |
专业分类
耳鼻咽喉 | 3454篇 |
儿科学 | 6202篇 |
妇产科学 | 2543篇 |
基础医学 | 37403篇 |
口腔科学 | 8072篇 |
临床医学 | 26613篇 |
内科学 | 47033篇 |
皮肤病学 | 11386篇 |
神经病学 | 23998篇 |
特种医学 | 10323篇 |
外国民族医学 | 7篇 |
外科学 | 31709篇 |
综合类 | 5646篇 |
现状与发展 | 7篇 |
一般理论 | 50篇 |
预防医学 | 12392篇 |
眼科学 | 5059篇 |
药学 | 19598篇 |
18篇 | |
中国医学 | 4507篇 |
肿瘤学 | 18533篇 |
出版年
2024年 | 216篇 |
2023年 | 1212篇 |
2022年 | 3119篇 |
2021年 | 6990篇 |
2020年 | 7829篇 |
2019年 | 13968篇 |
2018年 | 14079篇 |
2017年 | 14565篇 |
2016年 | 16060篇 |
2015年 | 17799篇 |
2014年 | 18885篇 |
2013年 | 20313篇 |
2012年 | 16987篇 |
2011年 | 16568篇 |
2010年 | 15917篇 |
2009年 | 11307篇 |
2008年 | 10698篇 |
2007年 | 9227篇 |
2006年 | 8552篇 |
2005年 | 7842篇 |
2004年 | 6736篇 |
2003年 | 6243篇 |
2002年 | 5531篇 |
2001年 | 4596篇 |
2000年 | 4101篇 |
1999年 | 2911篇 |
1998年 | 1260篇 |
1997年 | 1003篇 |
1996年 | 763篇 |
1995年 | 660篇 |
1994年 | 586篇 |
1993年 | 466篇 |
1992年 | 887篇 |
1991年 | 833篇 |
1990年 | 765篇 |
1989年 | 656篇 |
1988年 | 542篇 |
1987年 | 530篇 |
1986年 | 394篇 |
1985年 | 406篇 |
1984年 | 283篇 |
1983年 | 200篇 |
1982年 | 145篇 |
1981年 | 189篇 |
1980年 | 142篇 |
1979年 | 238篇 |
1978年 | 168篇 |
1976年 | 136篇 |
1974年 | 144篇 |
1973年 | 124篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
52.
53.
Can EGFR mutation status be reliably determined in pre‐operative needle biopsies from adenocarcinomas of the lung? 下载免费PDF全文
Kim Hein Lindahl Flemming Brandt Sørensen Søren Peter Jonstrup Karen Ege Olsen Siegfried Loeschke 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2015,123(4):289-297
The identification of EGFR mutations in non‐small‐cell lung cancer is important for selecting patients, who may benefit from treatment with EGFR tyrosine kinase inhibitors. The analysis is usually performed on cytological aspirates and/or histological needle biopsies, representing a small fraction of the tumour volume. The aim of the present investigation was to evaluate the diagnostic performance of this molecular test. We retrospectively included 201 patients with primary adenocarcinoma of the lung. EGFR mutation status (exon 19 deletions and exon 21 L858R point mutation) was evaluated on both pre‐operative biopsies (131 histological and 70 cytological) and on the surgical specimens, using PCR. Samples with low tumour cell fraction were assigned to laser micro‐dissection (LMD). We found nine (4.5%) patients with EGFR mutation in the lung tumour resections, but failed to identify mutation in one of the corresponding pre‐operative, cytological specimens. Several (18.4%) analyses of the pre‐operative biopsies were inconclusive, especially in case of biopsies undergoing LMD and regarding exon 21 analysis. Discrepancy of mutation status in one patient may reflect intra‐tumoural heterogeneity or technical issues. Moreover, several inconclusive results in the diagnostic biopsies reveal that attention must be paid on the suitability of pre‐operative biopsies for EGFR mutation analysis. 相似文献
54.
Sophocarpine attenuates toll‐like receptor 4 in steatotic hepatocytes to suppress pro‐inflammatory cytokines synthesis 下载免费PDF全文
55.
56.
Michelle E. Wilson Charles Kim Jacqueline Carrasco 《Orbit (Amsterdam, Netherlands)》2016,35(5):288-291
A 48-year-old smoker with a history of hyperthyroidism treated 10 years prior to presentation with radioactive iodine ablation of the thyroid gland presented to his ophthalmologist with a 2-week history of transient loss of vision in the right eye occurring for 1 to 2 hours each morning. He denied ocular pain, diplopia or change in the prominence of one or both eyes. Examination revealed 2 mm of relative proptosis on the right, bilateral temporal flare and lower lid retraction. There was minimal upper lid retraction and no evidence of lid lag. Ocular motility was full. Dilated fundoscopic examination revealed bilateral optic nerve edema, right more than left. CT of the orbit demonstrated enlargement of the extraocular muscles bilaterally with marked enlargement of the right medial rectus and left inferior rectus muscles resulting in crowding at the orbital apex bilaterally. Laboratory testing revealed the patient to be hyperthyroid. The patient was treated with high dose oral steroids followed by orbital radiation. Hyperthyroidism was managed by the patient’s primary care physician. Visual symptoms rapidly improved with oral steroids and orbital radiation. Optic nerve edema completely resolved. Repeat CT imaging demonstrated a reduction in the enlargement of the extraocular muscles with relief of bilateral optic nerve compression. 相似文献
57.
Kun‐Yong Sung Seungkoo Lee Yeonjin Jeong Sang‐Yeul Lee 《The Australasian journal of dermatology》2021,62(1):60-63
A classic pilomatricoma, which usually presents with an asymptomatic, solitary, firm, subcutaneous nodule in the head, neck, or extremities of the paediatric population, is easily diagnosed based on its characteristic clinical and histopathological features. However, its variants often pose particular diagnostic challenges to clinicians due to their rarity and diverse clinicopathological features. We present a new pseudocystic variant, manifesting as solid lesions floating in a fluid‐filled sac. 相似文献
58.
Sundaram Kavin Piuzzi Nicolas S. Patterson Brendan M. Stearns Kim L. Krebs Viktor E. Mont Michael A. 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2020,30(3):447-453
European Journal of Orthopaedic Surgery & Traumatology - The goals of this study were to compare patient satisfaction and wound-related complications in patients receiving 2-octyl cyanoacrylate... 相似文献
59.
60.
Peng‐fei Lei Shi‐long Su Ling‐yu Kong Cheng‐gong Wang Da Zhong Yi‐he Hu 《Orthopaedic Surgery》2019,11(5):914-920
Three‐dimensional (3D) printing technology, virtual reality, and augmented reality technology have been used to help surgeons to complete complex total hip arthroplasty, while their respective shortcomings limit their further application. With the development of technology, mixed reality (MR) technology has been applied to improve the success rate of complicated hip arthroplasty because of its unique advantages. We presented a case of a 59‐year‐old man with an intertrochanteric fracture in the left femur, who had received a prior left hip fusion. After admission to our hospital, a left total hip arthroplasty was performed on the patient using a combination of MR technology and 3D printing technology. Before surgery, 3D reconstruction of a certain bony landmark exposed in the surgical area was first performed. Then a veneer part was designed according to the bony landmark and connected to a reference registration landmark outside the body through a connecting rod. After that, the series of parts were made into a holistic reference registration instrument using 3D printing technology, and the patient's data for bone and surrounding tissue, along with digital 3D information of the reference registration instrument, were imported into the head‐mounted display (HMD). During the operation, the disinfected reference registration instrument was installed on the selected bony landmark, and then the automatic real‐time registration was realized by HMD through recognizing the registration landmark on the reference registration instrument, whereby the patient's virtual bone and other anatomical structures were quickly and accurately superimposed on the real body of the patient. To the best of our knowledge, this is the first report to use MR combined with 3D printing technology in total hip arthroplasty. 相似文献