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161.
Dan Liu Maria Lucia Pace Maria Goddard Rowena Jacobs Raphael Wittenberg Anne Mason 《Health economics》2021,30(1):36-54
Since 2010, adult social care spending in England has fallen significantly in real terms whilst demand has risen. Reductions in social care supply may also have impacted demand for NHS services, particularly for those whose care is provided at the interface of the health and care systems. We analyzed a panel dataset of 150 local authorities (councils) to test potential impacts on hospital utilization by people aged 65 and over: emergency admission rates for falls and hip fractures (“front‐door” measures); and extended stays of 7 days or longer; and 21 days or longer (“back‐door” measures). Changes in social care supply were assessed in two ways: gross current expenditure (per capita 65 and over) adjusted by local labor costs and social care workforce (per capita 18 and over). We ran negative binomial models, controlling for deprivation, ethnicity, age, unpaid care, council class, and year effects. To account for potential endogeneity, we ran instrumental variable regressions and dynamic panel models. Sensitivity analysis explored potential effects of funding for integrated care (the Better Care Fund). There was no consistent evidence that councils with higher per capita spend or higher social care staffing rates had lower hospital admission rates or shorter hospital stays. 相似文献
162.
Layland Eric K. Caldwell Linda L. Ram Nilam Smith Edward A. Wegner Lisa Jacobs Joachim J. 《Prevention science》2022,23(7):1251-1263
Prevention Science - An earlier trial of a school-based, preventative intervention, HealthWise South Africa, demonstrated some efficacy in preventing adolescent drinking and smoking in the Western... 相似文献
163.
Jordan C. Best BS Taylor Kohn MD Premal Patel MD Ruben Blachman-Braun MD Elaine de Quadros PhD Zeki Beyhan PhD Michael Jacobs MD Ranjith Ramasamy MD 《Andrologia》2021,53(7):e14094
In this study, we sought to determine whether sperm DNA fragmentation (DFI%) and high DNA stainability (HDS%) evaluated by sperm chromatin structure assay (SCSA) predict recurrent implantation failure (RIF) or pregnancy rate. A retrospective study was performed of consecutive cycles of ICSI treatment from 2009 to 2018. A total of 386 couples that underwent 1,216 frozen embryo transfer (FET) cycles were analysed. Mean female and male age was 34 ± 3.6 years and 37.3 ± 6.6 years, respectively, and a median total motile sperm count (TMSC) was 43.5 [9.9–105.5] million. Overall median DFI% and HDS% was 12 [7.1–18.9] and 9.6 [6.5–14.4] respectively. On multivariable analysis, DFI% and HDS% were not associated with RIF (DFI%: OR = 1.01, 95% CI: 0.98–1.04, p = .414; HDS%: OR = 0.97, 95% CI: 0.94–1.01, p = .107) or IVF success, defined as clinical pregnancy (DFI%: OR = 1.00, 95% CI: 0.99–1.01, p = .641; HDS%: OR = 1.01, 95% CI: 0.99–1.02, p = .565). We found that neither DFI% or HDS%, as assessed by SCSA, were predictive of RIF or pregnancy rate. This finding suggests that sperm DNA fragmentation does not predict RIF or pregnancy rate. 相似文献
164.
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166.
Edward Phillips Jaime Ponce Sunil Bhoyrul Scott A. Cunneen Eddie Gomez Moises Jacobs Mark Kipnes Robert T. Marema Michael Schwiers Jason R. Waggoner Janet DeMarchi 《Surgery for obesity and related diseases》2021,17(5):956-962
BackgroundThe long-term safety results of the REALIZE (Ethicon Endo-Surgery, Inc., Cincinnati, OH) adjustable gastric band collected in this prospective, multicenter study in patients with morbid obesity are presented.ObjectivesTo determine the reoperation rate, including band revisions, replacements, and explants, resulting from a serious adverse device-related event through years 4 and 5. Various efficacy measures were also assessed as secondary objectives.SettingNine academic and/or private institutions.MethodsThe participating institutions enrolled 303 patients, who were then assessed on an annual basis, with 231 patients completing 5 years of follow-up. The study parameters included reoperation rates, changes in percentage of excess weight loss (%EWL), and changes in body mass index (BMI), as well as parameters of diabetes and dyslipidemia. Quality of life was assessed using the Short Form (SF)-36 and the Impact of Weight on Quality of Life-Lite questionnaires.ResultsThe reoperation rate due to a serious adverse event in this population at 5 years after implantation with the REALIZE gastric band was 8.9%. The most common serious adverse event was band slippage, which affected 6.9% of the study population. The mean %EWL was 35.6% ± 26.84%, and the decrease in mean BMI was ?7.01 ± 5.45 kg/m2 at 5 years. Patients experienced improvements in mean glycated hemoglobin and serum lipid levels, in addition to improvements in the quality of life measures.ConclusionNo new safety concerns were identified during the 5 years of follow-up. Although the results of this study did not meet the predefined safety criteria of 8% or less, the safety profile and long-term effectiveness observed in this study are consistent with those in the current literature. 相似文献
167.
Santella Anthony J. Parish Carrigan Dan Rui Feaster Daniel J. Rodriguez Allan E. del Rio Carlos Armstrong Wendy S. Jacobs Petra Metsch Lisa R. 《Journal of community health》2021,46(3):557-564
Journal of Community Health - People living with HIV (PLWH) who use drugs experience worse health outcomes than their non-using counterparts. Little is known about how often they seek dental care... 相似文献
168.
Jacobs DK 《Proceedings of the National Academy of Sciences of the United States of America》1990,87(11):4406-4410
There is a significantly greater post-Cambrian decline in frequency of ordinal origination among serially constructed Bilateria, such as arthropods, than in nonserially constructed Bilateria. Greater decline in arthropod ordinal origination is not predicted by ecologic, diversity-dependent models of decline in the production of higher taxa. Reduction in ordinal origination indicates increased constraint on arthropod body-plan evolution. The dispersal of selector genes in the genomes of arthropods in conjunction with the retention of a simple regulatory hierarchy in development may have caused the increased constraint seen. Increased constraint would not be expected in those organisms that are not serially constructed and presumably have not retained the simple ancestral regulatory hierarchy in development of selector gene differentiation of serial elements. The hypothesis of differential constraint tested against the fossil record in this paper can be further tested by examination of the distribution of selector genes in the genomes of arthropods. 相似文献
169.
Cell division in higher plants: a cdc2 gene, its 34-kDa product, and histone H1 kinase activity in pea. 总被引:25,自引:5,他引:20
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H S Feiler T W Jacobs 《Proceedings of the National Academy of Sciences of the United States of America》1990,87(14):5397-5401
The mitotic cell cycle of yeast and animal cells is regulated by the cdc2 gene and its product, the p34 protein kinase, and by other components of the MPF or histone H1 kinase complex. We present evidence that cdc2, p34, and a histone H1 kinase also exist in higher plants. Protein extracts from 10 plant species surveyed display a 34-kDa component recognized by a monoclonal antibody directed against an evolutionarily conserved epitope of fission yeast p34. Nondenatured protein extracts of mitotic Pisum sativum (garden pea) tissues were fractionated by gel filtration, electrophoretically separated under denaturing conditions, and immunoblotted. p34 crossreactive material was apparent in both low and high molecular mass fractions, indicating that pea p34 occurs as both a monomer and as part of a high molecular mass complex. Histone H1 kinase activity was found predominantly in the higher molecular mass fractions, those to which the least phosphorylated form of pea p34 was confined. We also report the cloning of the pea homologue of cdc2 by polymerase chain reaction. DNA sequence analysis reveals perfect conservation of the hallmark "PSTAIR" sequence motif found in all cdc2 gene products analyzed to date. 相似文献
170.