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101.
Cristina Revilla-Monsalve Iván Zendejas-Ruiz Sergio Islas-Andrade Armida Báez-Salda?a Miguel Angel Palomino-Garibay Pedro Martín Hernández-Quiróz Cristina Fernandez-Mejia 《Biomedicine & Pharmacotherapy》2006,60(4):182-185
Biotin is a water-soluble vitamin that acts as a prosthetic group of carboxylases. Besides its role as carboxylase prosthetic group, biotin regulates gene expression and has a wide repertoire of effects on systemic processes. The vitamin regulates genes that are critical in the regulation of intermediary metabolism. Several studies have reported a relationship between biotin and blood lipids. In the present work we investigated the effect of biotin administration on the concentration of plasma lipids, as well as glucose and insulin in type 2 diabetic and nondiabetic subjects. Eighteen diabetic and 15 nondiabetic subjects aged 30-65 were randomized into two groups and received either 61.4 micromol/day of biotin or placebo for 28 days. Plasma samples obtained at baseline and after treatment were analyzed for total triglyceride, cholesterol, very low density lipoprotein (VLDL), glucose and insulin. We found that the vitamin significantly reduced (P=0.005) plasma triacylglycerol and VLDL concentrations. Biotin produced the following changes (mean of absolute differences between 0 and 28 day treatment+/-S.E.M.): a) triacylglycerol -0.55+/-0.2 in the diabetic group and -0.92+/-0.36 in the nondiabetic group; b) VLDL: -0.11+/-0.04 in the diabetic group and -0.18+/-0.07 in the nondiabetic group. Biotin treatment had no significant effects on cholesterol, glucose and insulin in either the diabetic or nondiabetic subjects. We conclude that pharmacological doses of biotin decrease hypertriglyceridemia. The triglyceride-lowering effect of biotin suggests that biotin could be used in the treatment of hypertriglyceridemia. 相似文献
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104.
Aitor Uribarri Iván J. Núñez-Gil Álvaro Aparisi Ramón Arroyo-Espliguero Charbel Maroun Eid Rodolfo Romero Víctor M. Becerra-Muñoz Gisela Feltes María Molina Marcos García-Aguado Enrico Cerrato Thamar Capel-Astrua Emilio Alfonso-Rodríguez Alex F. Castro-Mejía Sergio Raposeiras-Roubín Carolina Espejo Nerea Pérez-Solé Alfredo Bardají Carlos Macaya 《Revista espa?ola de cardiología》2021,74(7):608-615
Introduction and objectivesCoronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2. Atrial fibrillation (AF) is common in acute situations, where it is associated with more complications and higher mortality.MethodsAnalysis of the international HOPE registry (NCT04334291). The objective was to assess the prognostic information of AF in COVID-19 patients. A multivariate analysis and propensity score matching were performed to assess the relationship between AF and mortality. We also evaluated the impact on mortality and embolic events of the CHA2DS2-VASc score in these patients.ResultsAmong 6217 patients enrolled in the HOPE registry, 250 had AF (4.5%). AF patients had a higher prevalence of cardiovascular risk factors and comorbidities. After propensity score matching, these differences were attenuated. Despite this, patients with AF had a higher incidence of in-hospital complications such as heart failure (19.3% vs 11.6%, P = .021) and respiratory insufficiency (75.9% vs 62.3%, P = .002), as well as a higher 60-day mortality rate (43.4% vs 30.9%, P = .005). On multivariate analysis, AF was independently associated with higher 60-day mortality (hazard ratio, 1.234; 95%CI, 1.003-1.519). CHA2DS2-VASc score acceptably predicts 60-day mortality in COVID-19 patients (area ROC, 0.748; 95%CI, 0.733-0.764), but not its embolic risk (area ROC, 0.411; 95%CI, 0.147-0.675).ConclusionsAF in COVID-19 patients is associated with a higher number of complications and 60-day mortality. The CHA2DS2-VASc score may be a good risk marker in COVID patients but does not predict their embolic risk. 相似文献
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106.
Roland Fejes Gábor Kurucsai András Székely Iván Székely Áron Altorjay László Madácsy 《Surgical endoscopy》2010,24(8):1878-1885
Background
The aims of the present study were: (1) to assess the feasibility and safety of emergency endoscopic retrograde cholangiopancreatography (ERCP) and pancreatic duct (PD) stenting with small-caliber stents as a bridging procedure in acute biliary pancreatitis (ABP) patients in whom biliary endoscopic sphincterotomy (EST) proved difficult, failed or was contraindicated, and (2) to compare the clinical outcome of those patients having emergency ERCP with and without pancreatic stent. 相似文献107.
Fabricio Souza Neves Thais Helena Otto da Silva Gislaine Paviani Adriana Fontes Zimmermann Glaucio Ricardo Werner de Castro Ivânio Alves Pereira 《Clinical rheumatology》2010,29(7):777-779
Shrinking lungs syndrome (SLS) is a rare entity associated with autoimmune diseases and its underlying pathogenesis is still
unclear. We describe a series of seven consecutive cases of SLS in systemic lupus erythematosus, all of them with serositis
and six (85.7%) with anti-Ro/SSA antibodies. Our findings reinforce the hypothesis that SLS may be, in some cases, a consequence
of diaphragmatic restriction due to pleuritic pain, and we suggest anti-Ro/SSA as a marker of this subgroup of SLS. 相似文献
108.
Cerliani JP Stowell SR Mascanfroni ID Arthur CM Cummings RD Rabinovich GA 《Journal of clinical immunology》2011,31(1):10-21
Effective immunity relies on the recognition of pathogens and tumors by innate immune cells through diverse pattern recognition
receptors (PRRs) that lead to initiation of signaling processes and secretion of pro- and anti-inflammatory cytokines. Galectins,
a family of endogenous lectins widely expressed in infected and neoplastic tissues have emerged as part of the portfolio of
soluble mediators and pattern recognition receptors responsible for eliciting and controlling innate immunity. These highly
conserved glycan-binding proteins can control immune cell processes through binding to specific glycan structures on pathogens
and tumors or by acting intracellularly via modulation of selective signaling pathways. Recent findings demonstrate that various
galectin family members influence the fate and physiology of different innate immune cells including polymorphonuclear neutrophils,
mast cells, macrophages, and dendritic cells. Moreover, several pathogens may actually utilize galectins as a mechanism of
host invasion. In this review, we aim to highlight and integrate recent discoveries that have led to our current understanding
of the role of galectins in host–pathogen interactions and innate immunity. Challenges for the future will embrace the rational
manipulation of galectin–glycan interactions to instruct and shape innate immunity during microbial infections, inflammation,
and cancer. 相似文献
109.
110.
Rocha L Lorigados-Pedre L Orozco-Suárez S Morales-Chacón L Alonso-Vanegas M García-Maeso I Villeda-Hernández J Osorio-Rico L Estupiñán B Quintana C 《Progress in neuro-psychopharmacology & biological psychiatry》2007,31(6):1208-1218
The main goal of the present study was to evaluate binding to serotonin in the neocortex surrounding the epileptic focus of patients with mesial temporal lobe epilepsy (MTLE). Binding to 5-HT, 5-HT(1A), 5-HT(4), 5-HT(7) receptors and serotonin transporter (5-HTT) in T1-T2 gyri of 15 patients with MTLE and their correlations with clinical data, neuronal count and volume were determined. Autopsy material acquired from subjects without epilepsy (n=6) was used as control. The neocortex from MTLE patients demonstrated decreased cell count in layers III-IV (21%). No significant changes were detected on the neuronal volume. Autoradiography experiments showed the following results: reduced 5-HT and 5-HT(1A) binding in layers I-II (24% and 92%, respectively); enhanced 5-HT(4) binding in layers V-VI (32%); no significant changes in 5-HT(7) binding; reduced 5-HTT binding in all layers (I-II, 90.3%; III-IV, 90.3%, V-VI, 86.9%). Significant correlations were found between binding to 5-HT(4) and 5-HT(7) receptors and age of seizure onset, duration of epilepsy and duration of antiepileptic treatment. The present results support an impaired serotoninergic transmission in the neocortex surrounding the epileptic focus of patients with MTLE, a situation that could be involved in the initiation and propagation of seizure activity. 相似文献