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111.
Vanessa Galli Simone Simionatto Silvana Beutinger Marchioro Gustavo Henrique Ferrero Klabunde Fabricio Rochedo Concei??o Odir Ant?nio Dellagostin 《Clinical and Vaccine Immunology : CVI》2013,20(9):1370-1376
Mycoplasma hyopneumoniae is the etiological agent of porcine enzootic pneumonia (EP), which is a respiratory disease responsible for huge economic losses in the pig industry worldwide. The commercially available vaccines provide only partial protection and are expensive. Thus, the development of alternatives for the prophylaxis of EP is critical for improving pig health. The use of multiple antigens in the same immunization may represent a promising alternative. In the present study, seven secreted proteins of M. hyopneumoniae were cloned, expressed in Escherichia coli, and evaluated for antigenicity using serum from naturally and experimentally infected pigs. In addition, the immunogenicity of the seven recombinant proteins delivered individually or in protein cocktail vaccines was evaluated in mice. In Western blot assays and enzyme-linked immunosorbent assays, most of the recombinant proteins evaluated were recognized by convalescent-phase serum from the animals, indicating that they are expressed during the infectious process. The recombinant proteins were also immunogenic, and most induced a mixed IgG1/IgG2a humoral immune response. The use of these proteins in a cocktail vaccine formulation enhanced the immune response compared to their use as antigens delivered individually, providing evidence of the efficacy of the multiple-antigen administration strategy for the induction of an immune response against M. hyopneumoniae. 相似文献
112.
Frederico Sampaio Neves Andréa dos Anjos Pontual Paulo Sérgio Flores Campos Marco Antônio Gomes Frazão Solange Maria de Almeida Flávia Maria de Moraes Ramos-Perez 《Oral Radiology》2013,29(1):70-73
Dens invaginatus is a rare developmental anomaly and its etiology remains controversial. Radicular dens invaginatus is an unusual dental anomaly. The aims of this paper are to report the radiographic and tomographic findings of a case of radicular dens invaginatus and to discuss the relevant features associated with this dental anomaly. A 16-year-old female was referred to a private oral radiology clinic for orthodontic evaluation. Radiographically, a morphological alteration to the root portion of the right mandibular first premolar and the presence of a discrete radiolucent periapical lesion were observed. The diagnosis was only elucidated after cone-beam computed tomography (CBCT). The CBCT images revealed enlargement of the root, and a dilated invagination with limited enamel that had its open site along the lateral portion of the root without evidence of buccal and lingual expansion. The diagnosis of radicular dens invaginatus was then established. 相似文献
113.
Lucas Regatieri Barbieri Marcelo Luiz Peixoto Sobral Glaucio Mauren da Silva Ger?nimo Gilmar Geraldo dos Santos Evandro Sbaraíni Fabio Kirzner Dorfman Noedir Ant?nio Groppo Stolf 《Brazilian Journal Of Cardiovascular Surgery》2013,28(4):442-448
Introduction
Postoperative atrial fibrillation is the most common arrhythmia in cardiac surgery, its incidence range between 20% and 40%.Objective
Quantify the occurrence of stroke and acute renal insufficiency after myocardial revascularization surgery in patients who had atrial fibrillation postoperatively.Methods
Cohort longitudinal bidirectional study, performed at Portuguese Beneficent Hospital (SP), with medical chart survey of patients undergoing myocardial revascularization surgery between June 2009 to July 2010. From a total of 3010 patients were weaned 382 patients that presented atrial fibrillation preoperatively and/or associated surgeries. The study was conducted in accordance with national and international following resolutions: ICH Harmonized Tripartite Guidelines for Good Clinical Practice - 1996; CNS196/96 Resolution, and Declaration of Helsinki.Results
The 2628 patients included in this study were divided into two groups: Group I, who didn''t show postoperative atrial fibrillation, with 2302 (87.6%) patients; and group II, with 326 (12.4%) who developed postoperative atrial fibrillation. The incidence of stroke in patients was 1.1% without postoperative atrial fibrillation vs. 4% with postoperative atrial fibrillation (P<0.001). Postoperative acute renal failure was observed in 12% of patients with postoperative atrial fibrillation and 2.4% in the group without postoperative atrial fibrillation (P<0.001), that is a relation 5 times greater.Conclusion
In this study there was a high incidence of stroke and acute renal failure in patients with postoperative atrial fibrillation, with rates higher than those reported in the literature. 相似文献114.
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119.
Perin C Fagondes SC Casarotto FC Pinotti AF Menna Barreto SS Dalcin Pde T 《Sleep & breathing》2012,16(4):1041-1048
Purpose
Questions remain about the polysomnographic findings and the predictors for sleep desaturation in cystic fibrosis (CF) patients. Our study aimed to evaluate sleep parameters in a sample of adult CF patients comparing them with healthy controls and to determine the best predictors of sleep desaturation in CF patients with awake resting peripheral oxygen saturation (SpO2) ??90%.Methods
In a cross-sectional study, with data collected prospectively, 51 clinically stable adult CF patients (mean age 25.1?±?6.7?years) and 25 age-matched controls underwent an overnight polysomnography and answered sleep questionnaires. CF patients had their pulmonary function, 6-min walk test, and echocardiography assessed.Results
CF patients and control subjects had similar sleep architecture. However, CF patients had impaired subjective sleep quality and a higher arousal index than controls. The apnea?Chypopnea index was similar in both groups, and only two CF patients (3.9%) fulfilled the criteria for obstructive sleep apnea syndrome. Sleep desaturation was more common in CF patients (29.4% vs 0%; p?0.001). In a logistic regression model, we observed that awake resting SpO2 was the single best variable associated with sleep desaturation in CF population (p?0.001). The awake SpO2 <94% had a sensitivity, specificity, positive and negative predictive value for sleep desaturation of, respectively, 93.3%, 100%, 100%, and 97.3%.Conclusions
CF patients had a worse subjective sleep quality and small changes in sleep architecture. In nonhypoxic, adult CF patients, sleep desaturation is common, is not associated with obstructive sleep events, and can be accurately predicted by awake resting SpO2 <94%. 相似文献120.
Antó JM 《Current allergy and asthma reports》2012,12(3):192-200
The present review aims to identify and summarize epidemiologic investigations published during 2011 on the environmental
risk factors for asthma. Potentially eligible papers were identified by a MEDLINE search. In total, 1,130 items were retrieved.
Based on a broad definition of environment, the following topics were included: obesity, diet, vitamin D, air pollution, farming
environment, and social factors. Some of the more relevant contributions included evidence that 1) obesity precedes asthma,
2) fruit consumption is longitudinally associated with a lower risk of asthma and atopy, 3) a comprehensive statewide smoking
ban was followed by a reduction in hospital admissions for asthma, 4) asthma is one of the diseases showing the largest burdens
due to environmental tobacco smoke, 5) traffic-related urban air pollution is associated with bronchial inflammation as measured
by fractional exhaled nitric oxide and uncontrolled asthma, 6) aeroallergens and desert dust may contribute to the short-term
effects of air pollution and asthma, and 7) maternal exposure to air pollution before and during pregnancy may alter the immune
competence in offspring. 相似文献