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941.
Segmental staining on hepatic arteriography as a sign of intrahepatic portal vein obstruction 总被引:10,自引:0,他引:10
O Matsui T Takashima M Kadoya K Kitagawa R Kamimura H Itoh M Suzuki M Ida 《Radiology》1984,152(3):601-606
Peripheral obstruction of intrahepatic portal vein branches was detected by dynamic sequential computed tomography during arterial portography and subsequently confirmed surgically in 9 patients with hepatic neoplasm (7 hepatocellular carcinomas, 1 cholangiocarcinoma, and 1 metastatic lymphadenopathy from gastric carcinoma). In 1 patient, 2 obstructed segments were seen. Eight of these 10 segments showed more dense staining than other regions of the liver during infusion hepatic angiography. Retrograde opacification of the peripheral venules of the obstructed portion was seen in 2 of these 8 segments. This pattern was attributed to trans-sinusoidal or peripheral arterioportal shunting. In 5 cases, the segmental staining obscured the tumor stain, making the tumor appear larger than it actually was or causing it to be missed altogether. 相似文献
942.
Koji Kato Naokuni Uike Atsushi Wake Makoto Yoshimitsu Tomomi Tobai Yasushi Sawayama Yoshifusa Takatsuka Takahiro Fukuda Naoyuki Uchida Tetsuya Eto Yasuhiro Nakashima Tadakazu Kondo Jun Taguchi Toshihiro Miyamoto Hirohisa Nakamae Tatsuo Ichinohe Koji Kato Ritsuro Suzuki Atae Utsunomiya 《Hematological oncology》2019,37(1):54-61
Treatment options for patients with adult T cell leukemia/lymphoma (ATLL) who have relapsed disease after allogeneic hematopoietic stem cell transplantation (allo‐HSCT) are limited. To clarify which patients with ATLL are likely to benefit from these treatment options and to define patient populations for novel treatments, we performed a nationwide retrospective analysis of 252 Japanese patients who had relapsed ATLL after allo‐HSCT. Some long‐term survivors remained after tapering and withdrawal of immunosuppressive agents. Thirty‐six patients who received donor lymphocyte infusion had a better overall survival (OS) in comparison to those who did not [hazard ratio (HR), 0.63; 95% confidence interval (CI), 0.43‐0.93; P = .02], suggesting the efficacy of a graft‐versus‐ATLL (GvATLL) effect even after relapse. Multivariate analysis demonstrated that skin lesions at initial relapse of ATLL were independently associated with higher OS (HR, 0.41; 95% CI, 0.22‐0.74; P = .003), indicating that the skin is a susceptible target organ of GvATLL. This study suggested that enhancement of a GvATLL effect is a potential therapeutic option for relapsed disease after allo‐HSCT. Further investigations of incorporation of immune‐based approaches with new molecular target drugs into the therapeutic options of patients with ATLL before and after transplantation are warranted. 相似文献
943.
Asian Organization for Crohn's and Colitis and Asia Pacific Association of Gastroenterology consensus on tuberculosis infection in patients with inflammatory bowel disease receiving anti‐tumor necrosis factor treatment. Part 2: Management 下载免费PDF全文
Dong Il Park Tadakazu Hisamatsu Minhu Chen Siew Chien Ng Choon Jin Ooi Shu Chen Wei Rupa Banerjee Ida Normiha Hilmi Yoon Tae Jeen Dong Soo Han Hyo Jong Kim Zhihua Ran Kaichun Wu Jiaming Qian Pin‐Jin Hu Katsuyoshi Matsuoka Akira Andoh Yasuo Suzuki Kentaro Sugano Mamoru Watanabe Toshifumi Hibi Amarender S Puri Suk‐Kyun Yang 《Journal of gastroenterology and hepatology》2018,33(1):30-36
Because anti‐tumor necrosis factor (anti‐TNF) therapy has become increasingly popular in many Asian countries, the risk of developing active tuberculosis (TB) among anti‐TNF users may raise serious health problems in this region. Thus, the Asian Organization for Crohn's and Colitis and the Asia Pacific Association of Gastroenterology have developed a set of consensus statements about risk assessment, detection and prevention of latent TB infection, and management of active TB infection in patients with inflammatory bowel disease (IBD) receiving anti‐TNF treatment. Twenty‐three consensus statements were initially drafted and then discussed by the committee members. The quality of evidence and the strength of recommendations were assessed by using the Grading of Recommendations Assessment, Development, and Evaluation methodology. Web‐based consensus voting was performed by 211 IBD specialists from nine Asian countries concerning each statement. A consensus statement was accepted if at least 75% of the participants agreed. Part 2 of the statements comprised three parts: (3) management of latent TB in preparation for anti‐TNF therapy, (4) monitoring during anti‐TNF therapy, and (5) management of an active TB infection after anti‐TNF therapy. These consensus statements will help clinicians optimize patient outcomes by reducing the morbidity and mortality related to TB infections in patients with IBD receiving anti‐TNF treatment. 相似文献
944.
Consensus and contentious statements on the use of probiotics in clinical practice: A south east Asian gastro‐neuro motility association working team report 下载免费PDF全文
Kok‐Ann Gwee Warren Wei‐Rhen Lee Khoon Lin Ling Choon Jin Ooi Seng Hock Quak Yock Young Dan Kewin Tien‐Ho Siah James Guoxian Huang Andrew Seng Boon Chua Ida Normiha Hilmi Raja Affendi Raja Ali Christina Ong Marcellus Simadibrata Murdani Abdullah Jose D Sollano Somchai Leelakusolvong Sutep Gonlachanvit Yeong Yeh Lee Jane D Ricaforte‐Campos Yee Kian Yin Kuck‐Meng Chong Chong Yuen Wong 《Journal of gastroenterology and hepatology》2018,33(10):1707-1716
The concept of consuming microorganisms in the treatment of a medical condition and in health maintenance has gained much attraction, giving rise to an abundance of medical claims and of health supplements. This study identified relevant clinical questions on the therapeutic use of probiotics and reviewed the literature in irritable bowel syndrome, inflammatory bowel disease, impaired intestinal immunity, liver disease, intestinal infections, and common childhood digestive disorders. Statements were developed to address these clinical questions. A panel of experienced clinicians was tasked to critically evaluate and debate the available data. Both consensus and contentious statements are presented to provide to clinicians a perspective on the potential of probiotics and importantly their limitations. 相似文献
945.
946.
Fabiani Claudia Sota Jurgen Rigante Donato Vitale Antonio Emmi Giacomo Lopalco Giuseppe Vannozzi Lorenzo Guerriero Silvana Bitossi Alice Orlando Ida Franceschini Rossella Frediani Bruno Galeazzi Mauro Iannone Florenzo Tosi Gian Marco Cantarini Luca 《Clinical rheumatology》2018,37(10):2805-2809
Clinical Rheumatology - The primary aim of the study was to evaluate the efficacy of tumor necrosis factor (TNF)-α blockers adalimumab (ADA) and infliximab (IFX) in refractory... 相似文献
947.
Ari Zimran Nadia Belmatoug Bruno Bembi Patrick Deegan Deborah Elstein Diego Fernandez‐Sasso Pilar Giraldo Ozlem Goker‐Alpan Heather Lau Elena Lukina Zoya Panahloo Ida Vanessa D. Schwartz 《American journal of hematology》2018,93(2):205-212
The Gaucher Outcome Survey (GOS) is an international Gaucher disease (GD) registry established in 2010 for patients with a confirmed GD diagnosis, regardless of GD type or treatment status, designed to evaluate the safety and long‐term effectiveness of velaglucerase alfa and other GD‐related treatments. As of February 25, 2017, 1209 patients had enrolled, the majority from Israel (44.3%) and the US (31.4%). Median age at GOS entry was 40.4 years, 44.1% were male, and 13.3% had undergone a total splenectomy. Most patients had type 1 GD (91.5%) and were of Ashkenazi Jewish ethnicity (55.8%). N370S/N370S was the most prevalent genotype, accounting for 44.2% of genotype‐confirmed individuals (n = 847); however, there was considerable variation between countries. A total of 887 (73.4%) patients had received ≥1 GD‐specific treatment at any time, most commonly imiglucerase (n = 587), velaglucerase alfa (n = 507), and alglucerase (n = 102). Hematological and visceral findings at the time of GOS entry were close to normal for most patients, probably a result of previous treatment; however, spleen volume of patients in Israel was almost double that of patients elsewhere (7.2 multiples of normal [MN] vs. 2.7, 2.9 and 4.9 MN in the US, UK and rest of world), which may be explained by a greater disease severity in this cohort. This analysis aimed to provide an overview of GOS and present baseline demographic and disease characteristics of participating patients to help improve the understanding of the natural history of GD and inform the overall management of patients with the disease. 相似文献
948.
Epifanio Bagarinao Satoshi Maesawa Yuji Ito Naotaka Usui Jun Natsume Hirohisa Watanabe Minoru Hoshiyama Toshihiko Wakabayashi Gen Sobue Shinji Naganawa Haruo Isoda 《Clinical neurophysiology》2018,129(2):377-389
Objective
Epileptic spikes are associated with rapidly changing brain activation involving the epileptic foci and other brain regions in the “epileptic network”. We aim to resolve these activation changes using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) recordings.Methods
Simultaneous EEG-fMRI recordings from 9 patients with epilepsy were used in the analysis. Our method employed the whole scalp EEG data to generate regressors for the analysis of fMRI data using the general linear model.Results
We were able to resolve, with milliseconds temporal resolution, changes in activation patterns involving suspected epileptic foci and other brain regions in the epileptic network during spike and slow wave. Using summary maps (called SSWAS maps) which show the activation frequency of voxels, we found that suspected epileptic foci tend to be significantly active during this interval. SSWAS maps also enabled the detection of the epileptic foci in 4 of 5 patients where the conventional event-timing-based analysis failed to identify.Conclusion
These findings demonstrated the efficacy of the method and the potential application of SSWAS maps to identify epileptic foci.Significance
The method could help resolve activation changes during epileptic spike and could provide insights into the underlying pathophysiology of these changes. 相似文献949.
Michael B.H. Hall Ida A. Nissen Elisabeth C.W. van Straaten Paul L. Furlong Caroline Witton Elaine Foley Stefano Seri Arjan Hillebrand 《Clinical neurophysiology》2018,129(6):1221-1229
Objective
Kurtosis beamforming is a useful technique for analysing magnetoencephalograpy (MEG) data containing epileptic spikes. However, the implementation varies and few studies measure concordance with subsequently resected areas. We evaluated kurtosis beamforming as a means of localizing spikes in drug-resistant epilepsy patients.Methods
We retrospectively applied kurtosis beamforming to MEG recordings of 22 epilepsy patients that had previously been analysed using equivalent current dipole (ECD) fitting. Virtual electrodes were placed in the kurtosis volumetric peaks and visually inspected to select a candidate source. The candidate sources were compared to the ECD localizations and resection areas.Results
The kurtosis beamformer produced interpretable localizations in 18/22 patients, of which the candidate source coincided with the resection lobe in 9/13 seizure-free patients and in 3/5 patients with persistent seizures. The sublobar accuracy of the kurtosis beamformer with respect to the resection zone was higher than ECD (56% and 50%, respectively), however, ECD resulted in a higher lobar accuracy (75%, 67%).Conclusions
Kurtosis beamforming may provide additional value when spikes are not clearly discernible on the sensors and support ECD localizations when dipoles are scattered.Significance
Kurtosis beamforming should be integrated with existing clinical protocols to assist in localizing the epileptogenic zone. 相似文献950.
Tina Vilsbøll MD Stephen C. Bain FRCP Lawrence A. Leiter MD Ildiko Lingvay MD David Matthews DPhil Rafael Simó MD Ida Carøe Helmark MD Nelun Wijayasinghe MD Michael Larsen MD 《Diabetes, obesity & metabolism》2018,20(4):889-897