THE CLASSIFICATION OF HEMOLYTIC STREPTOCOCCI

1. The hemolytic variety of streptococcus is homogeneous, consisting of members that are nearly identical. 2. This homogeneity is most strikingly displayed in the behavior of these streptococci in the complement fixation reaction, all the strains studied reacting in a nearly identical way with all the antisera.     

THE EFFECT OF IRRITATION ON THE PERMEABILITY OF THE MENINGES FOR SALVARSAN

The subdural injection of normal salt solution, normal serum, serum salvarsanized in vivo or weak solutions of cyanide of mercury does not demonstrably increase the permeability of the spinal cord or brain for salvarsan which is circulating in the blood at the time of the subdural injection.     

A COMPARISON OF SIMULTANEOUS POLYGRAPH AND MICROGRAPH TRACINGS

From a study of the accompanying tracings we may conclude that: 1. The delicate mechanism of the micrograph registers the movements in the heart and blood-vessels more accurately than does the polygraph. 2. The inertia of the polygraph lever and diaphragm distorts the tracing. The difference between the results obtained with the two instruments is shown by the records made simultaneously with the micrograph and the polygraph. 3. The micrograph is particularly useful for recording heart sounds. Some records illustrating this are shown. We are directing especial attention to this and will report the results in a subsequent paper. 4. While the micrograph will not supersede the polygraph or electrocardiograph, we feel that it has distinct possibilities as a clinical instrument.     

A STUDY OF SERUM SALVARSANIZED IN VITRO

1. Addition of salvarsan to serum in vitro produces a spirocheticidal mixture which is increased in potency by heating. 2. The heated serum of salvarsan-treated patients is more spirocheticidal if it has been in contact with the clot over night than if it has been separated immediately after coagulation. This is not true with the serum from blood which has been salvarsanized in vitro. 3. The addition of salvarsan directly to serum produces a more potent mixture than results from the serum from blood to which salvarsan has been added in equivalent amounts. 4. The increase in activity of salvarsanized serum produced by heating to 56°C. is due in part to the removal of inhibitory substances in the serum and in part to a direct increase in spirocheticidal power in the heated salvarsan. 5. Both salvarsanized and neosalvarsanized serum are rendered more spirocheticidal by heating. 6. A more active spirocheticidal mixture is produced by mixing small amounts of salvarsan with the serum of a salvarsan-treated patient than by mixing the same amount with normal serum.     

FDG PET and PET/CT imaging in lymphoma and melanoma

FDG PET imaging is rapidly gaining acceptance in numerous clinical applications in oncology. PET/CT is a new imaging tool, which takes advantage of the excellent anatomic resolution of CT and the biologic characterization provided by FDG PET which together results in improvement in accuracy of detecting the extent of disease, provide a guide to biopsy or surgery, allow early response evaluation and prognostication. This article will provide specific clinical applications for the utilization of these imaging modalities in both lymphoma and melanoma.