全文获取类型
收费全文 | 305篇 |
免费 | 51篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 40篇 |
妇产科学 | 8篇 |
基础医学 | 56篇 |
口腔科学 | 10篇 |
临床医学 | 50篇 |
内科学 | 30篇 |
皮肤病学 | 1篇 |
神经病学 | 16篇 |
特种医学 | 2篇 |
外科学 | 64篇 |
综合类 | 5篇 |
预防医学 | 17篇 |
眼科学 | 7篇 |
药学 | 21篇 |
肿瘤学 | 28篇 |
出版年
2024年 | 2篇 |
2023年 | 3篇 |
2022年 | 8篇 |
2021年 | 7篇 |
2020年 | 13篇 |
2019年 | 11篇 |
2018年 | 15篇 |
2017年 | 13篇 |
2016年 | 14篇 |
2015年 | 18篇 |
2014年 | 19篇 |
2013年 | 19篇 |
2012年 | 14篇 |
2011年 | 18篇 |
2010年 | 17篇 |
2009年 | 6篇 |
2008年 | 10篇 |
2007年 | 10篇 |
2006年 | 15篇 |
2005年 | 9篇 |
2004年 | 8篇 |
2003年 | 7篇 |
2002年 | 5篇 |
1998年 | 2篇 |
1997年 | 4篇 |
1994年 | 2篇 |
1993年 | 3篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1988年 | 3篇 |
1987年 | 4篇 |
1985年 | 2篇 |
1984年 | 2篇 |
1983年 | 4篇 |
1980年 | 5篇 |
1969年 | 6篇 |
1968年 | 8篇 |
1967年 | 3篇 |
1939年 | 3篇 |
1938年 | 2篇 |
1932年 | 2篇 |
1930年 | 1篇 |
1928年 | 1篇 |
1917年 | 1篇 |
1916年 | 1篇 |
1914年 | 1篇 |
1913年 | 2篇 |
1912年 | 2篇 |
1908年 | 1篇 |
1898年 | 2篇 |
排序方式: 共有356条查询结果,搜索用时 15 毫秒
351.
Long-term results of the tension-free vaginal tape operation in an unselected group of 129 stress incontinent women 总被引:6,自引:0,他引:6
BACKGROUND: This study was undertaken to examine the long-term effects and effectiveness of the tension-free vaginal tape (TVT) procedure in an unselected group of women. METHOD: One hundred and twenty-nine stress urinary incontinent women (including primary, recurrent, mixed, and low pressure urethra cases) were studied prospectively and examined according to a strict protocol at a mean time of 6 years after their TVT operation. Cough and pad tests were used for objective evaluation, whereas visual analog scale and patients' verbal estimation were applied for subjective evaluation. RESULTS: As assessed by the cough stress test and the pad test, 74 and 81% of the women were totally cured, respectively. Symptoms possibly indicating reduced urine flow were reported from 17% of the women and recurrent urinary tract infections from 9.3% of the women. The de novo urge rate was 4.7%. The tape was visualized in 3.1% of the women and necessitated resection in 1.6% of the cases due to subjective discomfort. No serious or unexpected adverse events were revealed. CONCLUSION: The TVT operation appears to be a safe and effective anti-incontinence procedure in all female stress incontinence subgroups. 相似文献
352.
Comparison of clinical and physical measures of image quality in chest and pelvis computed radiography at different tube voltages 总被引:1,自引:0,他引:1
The aim of this work was to study the dependence of image quality in digital chest and pelvis radiography on tube voltage, and to explore correlations between clinical and physical measures of image quality. The effect on image quality of tube voltage in these two examinations was assessed using two methods. The first method relies on radiologists' observations of images of an anthropomorphic phantom, and the second method was based on computer modeling of the imaging system using an anthropomorphic voxel phantom. The tube voltage was varied within a broad range (50-150 kV), including those values typically used with screen-film radiography. The tube charge was altered so that the same effective dose was achieved for each projection. Two x-ray units were employed using a computed radiography (CR) image detector with standard tube filtration and antiscatter device. Clinical image quality was assessed by a group of radiologists using a visual grading analysis (VGA) technique based on the revised CEC image criteria. Physical image quality was derived from a Monte Carlo computer model in terms of the signal-to-noise ratio, SNR, of anatomical structures corresponding to the image criteria. Both the VGAS (visual grading analysis score) and SNR decrease with increasing tube voltage in both chest PA and pelvis AP examinations, indicating superior performance if lower tube voltages are employed. Hence, a positive correlation between clinical and physical measures of image quality was found. The pros and cons of using lower tube voltages with CR digital radiography than typically used in analog screen-film radiography are discussed, as well as the relevance of using VGAS and quantum-noise SNR as measures of image quality in pelvis and chest radiography. 相似文献
353.
Infants predict other people's action goals 总被引:1,自引:0,他引:1
Do infants come to understand other people's actions through a mirror neuron system that maps an observed action onto motor representations of that action? We demonstrate that a specialized system for action perception guides proactive goal-directed eye movements in 12-month-old but not in 6-month-old infants, providing direct support for this view. The activation of this system requires observing an interaction between the hand of the agent and an object. 相似文献
354.
Norovirus, the cause of winter vomiting disease, has emerged in recent years to be a major cause of sporadic and epidemic gastroenteritis worldwide. The virus has been estimated to cause >200,000 deaths each year in developing countries. Although the virus is highly contagious, volunteer and field studies have shown that a subset of individuals appears resistant to infections. A single nucleotide mutation (G428A) in the fucosyltransferase gene (FUT2) on chromosome 19 provides strong protection from infection in 20% of the white population. Histo-blood group ABO(H) antigens with terminal fucose are believed to function as receptors for human norovirus in the gastrointestinal tract, but also negatively charged potential receptors have been identified. Norovirus infection is a unique example where a single nucleotide mutation in a fucosyltransferase gene plays a crucial role in susceptibility to one of the most common viral diseases. This review discusses the role of host genetics and carbohydrate structures in susceptibility to winter vomiting disease. 相似文献
355.
Jenny Rydén Mark Clements Agneta Wikman Eva Hellström-Lindberg Gustaf Edgren Petter Höglund 《Transfusion》2023,63(11):2040-2051
Background
Many patients with myelodysplastic syndromes (MDS) need repeated red blood cell transfusions which entails a risk of immunization and antibody formation. Associations between alloantibodies, autoantibodies and increased transfusion requirements have been reported, but their relationship remains unclear. In this study, we analyzed factors potentially associated with red blood cell alloimmunization, as well as changes in transfusion intensity and post-transfusion hemoglobin increments.Methods
In a retrospective cohort study, we linked Swedish MDS patients diagnosed between 2003 and 2017 to transfusion and immunohematology data. Potentially associated factors were analyzed using Cox proportional hazards regression. The transfusion rate after detected alloimmunization was analyzed using a fixed effects Poisson regression. Post-transfusion hemoglobin increments before and after alloimmunization were compared using a mixed effects regression.Results
Alloantibodies following MDS diagnosis were detected in 50 out of 429 patients (11.7%). Female sex and a positive direct antiglobulin test (DAT) were independently associated with alloimmunization, with hazard ratios of 2.02 (95% confidence interval [CI] 1.08–3.78) and 9.72 (95% CI, 5.31–17.74), respectively. The transfusion rate following alloimmunization was increased with an incidence rate ratio of 1.33 (95% CI, 0.98–1.80) and the post-transfusion hemoglobin increment after alloimmunization was 1.40 g/L (95% CI, 0.52–2.28) lower per red blood cell unit (p = .002) compared to before alloimmunization, in multivariable analyses.Discussion
Alloimmunization against blood group antigens was associated with sex, DAT-positivity, increased transfusion needs, and lower post-transfusion hemoglobin increments. These findings warrant further investigation to evaluate the clinical significance of up-front typing and prophylactic antigen matching in patients with MDS. 相似文献356.
David Mataix-Cols PhD Kayoko Isomura MD PhD Gustaf Brander PhD Isabell Brikell PhD Paul Lichtenstein PhD Zheng Chang PhD Henrik Larsson PhD Ralf Kuja-Halkola PhD Kevin J. Black MD Anna Sidorchuk MD PhD Lorena Fernández de la Cruz PhD 《Movement disorders》2023,38(8):1419-1427