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排序方式: 共有768条查询结果,搜索用时 15 毫秒
101.
Cor HJ Lamers Stefan Sleijfer Sabine van Steenbergen Pascal van Elzakker Brigitte van Krimpen Corrien Groot Arnold Vulto Michael den Bakker Egbert Oosterwijk Reno Debets Jan W Gratama 《Molecular therapy》2013,21(4):904-912
Autologous T cells genetically modified to express a chimeric antibody receptor
(CAR) against carboxy-anhydrase-IX (CAIX) were administered to 12 patients with
CAIX-expressing metastatic renal cell carcinoma (RCC). Patients were treated in
three cohorts with a maximum of 10 infusions of a total of 0.2 to 2.1 ×
109 CAR T cells. CTC grade 2–4 liver enzyme disturbances
occurred at the lowest CAR T cell doses, necessitating cessation of treatment in
four out of eight patients in cohorts 1 and 2. Examination of liver biopsies
revealed CAIX expression on bile duct epithelium with infiltration of T cells,
including CAR T cells. Subsequently four patients were pre-treated with CAIX
monoclonal antibody (mAb) G250 to prevent CAR-specific toxicity and showed no
liver toxicities and indications for enhanced peripheral T cell persistence. No
clinical responses were recorded. This report shows that CAIX-targeting CAR T
cells exerted antigen-specific effects in vivo and induced liver
toxicity at the lowest dose of 0.2 × 109 T cells applied,
illustrating the potency of receptor-modified T cells. We provide in-patient
proof that the observed “on-target” toxicity is antigen-directed and
can be prevented by blocking antigenic sites in off-tumor organs and allowing
higher T cell doses. 相似文献
102.
Purpose: To review the literature concerning neurophysiological methods to assess spasticity with respect to mechanisms and methodology, and to describe the three most commonly used methods: the Hoffmann reflex (H-reflex), the Tendon reflex (T-reflex), and the Stretch Reflex (SR). Method: A systematic internet database search was performed to identify neurophysiological measurement methods of spasticity. A systematic exclusion procedure resulted in 185 included references, completed by additional informal search. For this paper, information about the H-, T- and stretch reflexes was extracted from these references. Results: Although the reflexes are basically monosynaptic, there are many supraspinal pathways which modulate the responses in terms of their amplitude and latency. As a consequence the methods are sensitive to a considerable number of experimental conditions and are characterized by a moderate reliability and sensitivity. Correlations with other (i.e. biomechanical, neurophysiological or clinical) spasticity assessment parameters are moderate to poor. Standardised and broadly accepted protocols are still largely lacking preventing an effective exchange of knowledge. Conclusions: The clinical and experimental use of the three methods is restricted due to moderate reliability and sensitivity. It is recommended to perform combined neurophysiological?-?biomechanical assessment of spasticity during active, functional movement. 相似文献
103.
Biliary stricture dilatation: multicenter review of clinical management in 73 patients 总被引:7,自引:0,他引:7
Mueller PR; vanSonnenberg E; Ferrucci JT Jr; Weyman PJ; Butch RJ; Malt RA; Burhenne HJ 《Radiology》1986,160(1):17-22
Eighty-nine biliary strictures in 73 patients who had undergone percutaneous balloon dilatation were reviewed to determine long-term patency rates and clinical management problems. The majority of dilatations were performed in patients with anastomotic strictures (n = 44), iatrogenic strictures (n = 28), and strictures associated with sclerosing cholangitis (n = 17). Patency rates after 36 months or more were 67%, 76%, and 42%, respectively. Complications, mostly minor, occurred in less than 7% of patients. Of patients with significant biliary obstruction, 15% had little or no intrahepatic biliary duct dilatation demonstrated by cross-sectional imaging and/or direct cholangiography. No definite conclusions could be drawn about the utility of long-term internal/external stenting. 相似文献
104.
One hundred six patients underwent extracorporeal shock wave lithotripsy for cholelithiasis. Of these, 28 patients underwent cholangiographically guided lithotripsy for bile duct stones to assist nonoperative stone removal by endoscopic or radiologic intervention. Fragmentation occurred in 20 of 28 cases (71%) with an average of two lithotripsy sessions. Hemobilia was observed in four patients (14%) for a 24-hour period. Seventy-eight of the 106 were outpatients with symptomatic cholecystolithiasis with one to five calculi who underwent cholecystographic or ultrasound-(US) guided shock wave lithotripsy as definitive therapy. US examination showed stone fragmentation in 86% of cases. With an average of 1.6 treatment sessions and 4,750 shocks, fragments were 4 mm or smaller in 46% of patients. Nine percent of patients had no fragments after an average of 10 weeks, but long-term follow-up is not yet available. Two patients developed acute pancreatitis attributable to fragment passage and one patient acute cholecystitis, likely due to cystic duct obstruction by a fragment. 相似文献
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109.
Mastromatteo JF; Mindell HJ; Mastromatteo MF; Magnant MB; Sturtevant NV; Shuman WP 《Radiology》1997,202(2):523
110.