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51.
Hakan Tuna Fuat Torun Ayse Nur Izol Torun Ahmet Erdogan 《Journal of clinical neuroscience》2008,15(10):1154-1156
We herein present a patient with intrasellar epidermoid cyst presenting as pituitary apoplexy, who was operated upon with a trans-sphenoidal approach. The clinical presentation, radiological and histological differential diagnosis and type of surgical intervention for intrasellar epidermoid cysts are discussed. 相似文献
52.
Asli Somunkiran Abdurrahman Coskun Fuat Demirci Oguz Yucel 《Gynecological endocrinology》2008,24(2):79-83
The aim of the present prospective controlled study was to examine the influence of 17beta-estradiol and tibolone on tumor necrosis factor-alpha (TNF-alpha) levels in healthy women with surgical menopause. Forty-five surgically menopausal women were included in the study. Thirty women were randomized to receive tibolone 2.5 mg or 17beta-estradiol 2 mg daily for 16 weeks. Fifteen surgically menopausal women who refused hormone therapy served as controls. Serum was collected from the subjects at baseline and at the end of the study for TNF-alpha assay. Neither tibolone nor 17beta-estradiol showed a significant influence on TNF-alpha level at the end of 16 weeks in comparison with baseline. Although tibolone induced a trend toward decreased level of TNF-alpha (3.30 +/- 0.42 vs. 2.56 +/- 1.94 microg/dl), this was non-significant. The slight increase observed in TNF-alpha level in the control group was also insignificant (3.60 +/- 1.20 vs. 4.10 +/- 0.70 microg/dl). Overall, these results demonstrate no significant effects of either tibolone or 17beta-estradiol on circulating TNF-alpha level in surgically menopausal women. However, the significant difference achieved between the tibolone and control group after treatment is promising and needs to be investigated in trials with longer treatment periods. 相似文献
53.
Improving the biomechanical properties of the T-fix using oblique direction: in vitro study on bovine menisci 总被引:1,自引:1,他引:0
Sinan Karaoglu Fuat Duygulu Muharrem Inan Ali Baktir 《Knee surgery, sports traumatology, arthroscopy》2002,10(3):198-201
This study compared pullout strengths of the T-fix device versus horizontal suture toward improving T-fix biomechanical properties. Twenty bovine medial menisci were used for this study. Four groups were tested and mean tearing stress were obtained. In group 1 a standard T-fix suture was performed (50.2+/-4.2 N); in group 2 horizontal mattress sutures were placed in the meniscus using 2-0 vicryl (54.6+/-4.2 N); in group 3 three T-fix suture anchors were placed: the central suture a double suture anchor and those on either side single suture anchors, resulting in two horizontal sutures (61.8+/-3.8 N); in group 4 we modified the technique used in group 3. The double suture anchor was placed the incision, at a 30 degrees angle oblique to the horizontal (71.0+/-5.9 N). There was a statistically significant difference between groups 3 and 4 but not between groups 1 and 2. In conclusion: Using a T-fix suture anchor in the standard technique has similar biomechanical properties to the horizontal mattress suture. To improve the tensile properties of the T-fix suture a double T-fix suture anchor should be used obliquely to the other two single T-fix sutures on either side. 相似文献
54.
Refik Erdim Aydin Celiker Gökmen Gemici Sena Tokay Gözde Ülfer Fuat Dede Serdar Turhal Ahmet Oktay 《Central European Journal of Medicine》2009,4(3):327-330
The aim of the study was to investigate the role of cTnT for the prediction of long term cardiac dysfunction after epirubicin-containing
adjuvant chemotherapy for breast cancer. The study group comprised of 45 patients (all female; mean age 48 ±8 years), treated
with epirubicin-containing adjuvant chemotherapy for stage 2 and stage 3 breast cancer. Patients received either 4 cycles
of cyclophosphamide plus epirubicin (90 mg/m2) (n=23; stage 2 breast cancer) or 6 cycles of cyclophosphamide plus epirubicin (75 mg/m2) plus fluorouracil (n=18; stage 3 breast cancer). Venous blood samples were drawn, before and 72 hours after, every cycle
of chemotherapy for the measurement of cTnT. Cardiac assessment was carried out at baseline and 1 year after chemotherapy
by clinical evaluation, electrocardiography, radio-nuclide ventriculography (RNV) and transthoracic echocardiography. All
patients remained free of clinical heart failure during the study period. In 26 patients (63%), cTnT was elevated after chemotherapy.
Mean left ventricular ejection fraction, assessed by RNV at baseline and one year after chemotherapy, were 61±8% and 56±7%
(p<0.0001). The sensitivity and specifity of cTnT for the detection of left ventricular systolic dysfunction at one year were
69% and 39% respectively. Echocardiographic examinations at baseline and one year after chemotherapy revealed a significant
decrease in E/A ratio from 1.15±0.3 to 0.9±0.2 in cTnT positive patients, suggesting diastolic dysfunction. In conclusion,
elevated serum cTnT levels after epirubicin-containing adjuvant chemotherapy for stage 2 and stage 3 breast cancer, predict
future cardiac dysfunction with moderate sensitivity and poor specificity. 相似文献
55.
Uuml lkuuml Ouml nerBaran Tokar Mustafa Fuat AccedilinodotkalinodotnHuuml seyin Idot lhan Niluuml fer Tel 《Journal of pediatric surgery》2002,37(1):127-129
The occurrence of true extrarenal Wilms' tumor is extremely rare. The most frequently noted extrarenal sites are the retroperitoneal and inguinal regions. In the female genital tract, the occurrence of Wilms' tumor has been documented in the uterus, endocervix, and ovary in isolated case reports. In this article the authors describe a case of ovarian Wilms' tumor in a 3.5-year-old girl. Her abdominal ultrasound scan and computed tomography scan showed a solid mass with cystic components on the left lower quadrant. Total excision was performed with left salpingo-oophorectomy. There was no other mass and also no evidence of metastasis. To the best of the authors' knowledge, this patient is the first reported case of primary ovarian Wilms' tumor arising in childhood. 相似文献
56.
Cekmen MB Balat A Balat O Aksoy F Yurekli M Erbagci AB Sahinoz S 《Clinical biochemistry》2004,37(2):146-148
OBJECTIVE: To observe the adrenomedullin (AM) and total nitrite levels in the milk of preeclamptic and normal pregnant women. DESIGN AND METHODS: Fifteen women with preeclampsia and 15 normal pregnant women were included in the study. Total nitrite was quantitated by Griess reaction, while AM was measured by HPLC. RESULTS: The levels of AM and total nitrite in colostrum and 30th-day breast milk were decreased in preeclamptics. Total nitrite levels (micromol/l) were 56.09 +/- 11.18 vs. 82.20 +/- 12.01, P < 0.05, in colostrum of preeclamptics and controls, respectively. The level of total nitrite was 37.75 +/- 12.10 vs. 53.28 +/- 10.25, P < 0.05, in 30th-day milk of same patients. AM levels (pg/ml) were 11.18 +/- 1.11 vs. 16.59 +/- 1.24, P < 0.0001, in colostrum of preeclamptics and controls, respectively. In 30th-day milk of same patients, AM levels were 8.41 +/- 1.39 vs. 12.18 +/- 1.48, P < 0.005, respectively. CONCLUSION: This report shows for the first time that human milk has decreased levels of AM and total nitrite in preeclampsia. 相似文献
57.
Arslan S Gundogdu F Acikel M Kantarci AM 《The international journal of cardiovascular imaging》2007,23(2):277-279
A 45 year-old asymptomatic man was admitted to preoperative cardiovascular evaluation for noncardiac surgery. Physical examination
and ECG were normal. Transthoracic echocardiography showed a 17 × 35 mm suspicious hyperechoic mass in the interventricular
septum. Multi-slice computed tomograpy (MSCT) was used. Volume rendered image and an axial maximal intensity projection image
demonstrated a mass with a density consistent with fat tissue ( − 78 HU).
The MSCT findings were diagnostic of a benign lipoma. Thus, this mass was noninvasively diagnosed as cardiac lipoma. Neither
life-threatening arrhythmia on Holter monitoring nor myocardial ischemia on exercise scintigraphy was observed.
Transthoracic echocardiography is usually the initial diagnostic test in patients with a suspected cardiac mass. However,
its sensitivity for differentiating tissue characteristics is limited. MSCT allow for detailed delineation of intra and pericardiac
masses. In conclusion, we demonstrated the value of cardiac MSCT to diagnose an interventricular lipoma. 相似文献
58.
Engin O Ipekci F Yildirim M Kulan A Yagci A Dalgic A Calik B 《The Indian journal of surgery》2010,72(5):362-366
In our experimental study, the aim was to recover vocal cord physiology in cutting of recurrent laryngeal nerve, thus phrenic-recurrent
nerve transposition was planned in rabbits. Experiments were performed on 10 experimental and 10 control rabbits. The right
recurrent nerve was cut in the control group, while in the experiment group, the right recurrent nerve was cut. Then, a right
phrenic-recurrent nerve end-to-end anastomosis was performed and the results were evaluated. After the 3rd postoperative week,
videolaryngoscopy (VLS) and intramuscular electromyography (EMG) could not be evaluated in 1 rabbit from the experimental
group which had died during anesthesia. In eight of the nine rabbits in the experiment which underwent VLS and EMG, activity
was recorded in the right vocal cords. On light microscopic examination, atrophy was not detected in the vocal cord muscles
of 9 rabbits among the 10 in the experiment group, while all rabbits in the control group and 1 rabbit in the experiment group
were diagnosed with vocal cord atrophy. A success rate of approximately 90% was obtained based on the pathologic examination.
We believe that the method can be used in patients without any contraindications, considering the complications of tracheostomy
and the quality of life. 相似文献
59.
Srunthron Akkarathamrongsin Masaya Sugiyama Kentaro Matsuura Fuat Kurbanov Yong Poovorawan Yasuhito Tanaka Masashi Mizokami 《Hepatology research》2010,40(10):956-962
Aim: Recent human genome‐wide association studies (GWAS) revealed a strong association between IL28B gene variation and the pegylated interferon‐α with ribavirin (PEG‐IFN‐α/RBV) treatment response in chronic hepatitis C patients. Two single nucleotide polymorphisms (SNP), rs8103142 and rs11881222 located in the IL28B gene, were found in significant association with the viral clearance. The present study employed these SNPs to develop a new accessible screening method allowing identification of potential non‐responders before starting the therapy. Methods: Primer sets were designed to amplify rs8103142 and rs11881222 fragments from genomic DNA extracted from serum samples. This method was validated using microarray typing (GWAS) and applied for genotyping of 68 hepatitis C virus‐infected patients with PEG‐IFN‐α/RBV treatment at baseline. Results: In comparison with GWAS, the screening method showed 100% and 95.6% accuracy in typing of rs8103142 and rs11881222, respectively, indicating incomplete specificity but 100% of sensitivity in both. Genotyping by both SNP showed that 53 (77.9%), 14 (20.6%) and one (1.5%) of the patients were of major homozygous, heterozygous and minor homozygous type, respectively. The majority (85%) of homozygous patients exhibited response to therapy in contrast to heterozygous patients (29%). Among all genotyped only one case was found with the minor homozygous genotype which had late virological response to therapy before relapsing. Conclusion: This study described a highly sensitive assay that can be useful in determining SNP genotypes as well as in predicting the response to IFN‐based treatment. 相似文献
60.