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51.
Marcos Rabelo de Freitas Déborah Nogueira Vasconcelos Ângela Elizabeth de Holanda Araújo Freitas José Holanda Maia Filho Claudia de Castro e Silva 《Revista brasileira de otorrinolaringologia (English ed.)》2013,79(4):480-486
Cystic Fibrosis (CF) results from mutation in the transmembrane conductance regulator gene, responsible for controlling secretory processes. The upper airways (UA) are usually involved in the form of chronic pansinusitis.ObjectiveTo evaluate UA changes in patients with CF and to establish the correlations between sinonasal CT and endoscopic endonasal findings and disease severity.MethodCross-sectional and prospective study with 20 patients older than 5 years with CF, assessing the Shwachman-Kulczycki (S-K) score, paranasal sinus tomography (CT) (Lund-Mackay score) and nasal endoscopy (Meltzer score).ResultsCT scan alterations were observed in 94% of cases. Endoscopic alterations findings in the upper airways were found in 10 patients. Nasal polyps were found in 3 patients (15%). There was a correlation between the intensity of changes on the CT and S-K score (p = 0.0097), and between endoscopic findings and S-K score (p = 0.0318). There was a positive correlation between the presence of chronic colonization and endoscopic findings (p = 0.0325), which was not observed on the CT (p = 0.2941).ConclusionThere is an inverse correlation between the S-K clinical score and nasal endoscopy and CT findings. Therefore, patients who are clinically more severe according to the S-K score have greater UA involvement. 相似文献
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Camila Fernanda Novak Pinheiro de Freitas Fabiane Mulinari-Brenner Hanae Rafaela Fontana Arthur Conelian Gentili Mariana Hammerschmidt 《Anais brasileiros de dermatologia》2013,88(4):627-630
Ichthyoses are a common group of keratinization disorders. A non-inflammatory
generalized persistent skin desquamation is observed. It is characterized by
increased cell turnover, thickening of the stratum corneum and functional changes of
sebaceous and sweat glands. All of these favor fungal proliferation. Dermatophytes
may infect skin, hair and nails causing ringworm or tinea. They have the ability to
obtain nutrients from keratinized material. One of its most prevalent genera is
Trichophyton rubrum. Although tineas and ichthyoses are quite common, the association
of the two entities is rarely reported in the literature. Three cases of ichthyosis
associated with widespread infection by T. rubrum are presented. Resistance to
several antifungal treatments was responsible for worsening of ichthyosis signs and
symptoms. 相似文献
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Mirlaine R. Freitas Matheus P. Freitas Renato L. G. Macedo 《Bulletin of environmental contamination and toxicology》2014,93(4):489-492
Soil sorption, described as logKOC (the logarithm of the soil/water partition coefficient normalized to organic carbon), was modeled using the augmented multivariate image analysis applied to quantitative structure–property relationship method for a series of 11 carboxylic acid herbicides. The statistical model was found to be highly predictive and reliable to estimate logKOC of other persistent organic pollutants in the soil, which are analogues of the carboxylic acids used in the QSPR model. The QSPR model derived from images corresponding to the chemical structures of the 11 herbicides is superior to the uniparameter model based on the octanol/water partition coefficient (logP) and, in addition, a pattern recognition model was built using principal component analysis. This model allowed clustering and separating compounds with low/moderate soil sorption from those with moderate/high soil sorption (compounds with the aryloxy function) using the second principal component. 相似文献
56.
MicroCT assessment of bone microarchitecture in implant sites reconstructed with autogenous and xenogenous grafts: a pilot study 下载免费PDF全文
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High rate of hematological responses to sorafenib in FLT3‐ITD acute myeloid leukemia relapsed after allogeneic hematopoietic stem cell transplantation 下载免费PDF全文
Tiago De Freitas Sarah Marktel Simona Piemontese Matteo G. Carrabba Cristina Tresoldi Carlo Messina Maria Teresa Lupo Stanghellini Andrea Assanelli Consuelo Corti Massimo Bernardi Jacopo Peccatori Luca Vago Fabio Ciceri 《European journal of haematology》2016,96(6):629-636
Relapse represents the most significant cause of failure of allogeneic hematopoietic stem cell transplantation (HSCT) for FLT3‐ITD‐positive acute myeloid leukemia (AML), and available therapies are largely unsatisfactory. In this study, we retrospectively collected data on the off‐label use of the tyrosine kinase inhibitor sorafenib, either alone or in association with hypomethylating agents and adoptive immunotherapy, in 13 patients with post‐transplantation FLT3‐ITD‐positive AML relapses. Hematological response was documented in 12 of 13 patients (92%), and five of 13 (38%) achieved complete bone marrow remission. Treatment was overall manageable in the outpatient setting, although all patients experienced significant adverse events, especially severe cytopenias (requiring a donor stem cell boost in five patients) and typical hand‐foot syndrome. None of the patients developed graft‐vs.‐host disease following sorafenib alone, whereas this was frequently observed when this was given in association with donor T‐cell infusions. Six patients are alive and in remission at the last follow‐up, and four could be bridged to a second allogeneic HSCT, configuring a 65 ± 14% overall survival at 100 d from relapse. Taken together, our data suggest that sorafenib might represent a valid treatment option for patients with FLT3‐ITD‐positive post‐transplantation relapses, manageable also in combination with other therapeutic strategies. 相似文献
59.
Orlando Oliveira de Morais érica Freitas Lima Lemos Márcia Carolline dos Santos Sousa Ciro Martins Gomes Izelda Maria Carvalho Costa Carmen Déa Ribeiro de Paula 《Anais brasileiros de dermatologia》2013,88(2):238-242
Melasma represents a pigmentary disorder that is difficult to treat. This study aims
to broadly review the use of ablative lasers (Er:YAG and CO2) in the treatment of
melasma, presenting the level of evidence of studies published to date. A total of 75
patients were enrolled in four case series studies (n=39), one controlled clinical
trial (n=6) and one randomized controlled clinical trial (n=30). Studies on the
Er:YAG laser showed better results with the use of short square-shaped pulses, which
determined low rates of post-inflammatory hyperpigmentation and long-lasting
maintenance of results. Likewise, studies on the CO2 laser proved the benefits of
short pulse duration along with low-density energy. Post-treatment maintenance with
the use of antipigmenting creams was necessary and effective to sustain long-term
results. Ablative lasers may represent another useful and effective tool against
melasma. Postinflammatory hyperpigmentation and difficulty in sustaining long-term
results still represent the main limitations to a broader use of ablative lasers.
Based on actual evidence, the use of this technology should be restricted to patients
with recalcitrant disease. Further studies will help establish optimal laser
parameters and treatment regimens. 相似文献
60.