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排序方式: 共有6950条查询结果,搜索用时 851 毫秒
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John S March Martin E Franklin Henrietta Leonard Abbe Garcia Phoebe Moore Jennifer Freeman Edna Foa 《Neuropsychopharmacology》2007,61(3):344-347
BACKGROUND: The presence of a comorbid tic disorder may predict a poorer outcome in the acute treatment of pediatric obsessive-compulsive disorder (OCD). METHODS: Using data from the National Institute of Mental Health (NIMH)-funded Pediatric OCD Treatment Study (POTS) that compared cognitive-behavior therapy (CBT), medical management with sertraline (SER), and the combination of CBT and SER (COMB), to pill placebo (PBO) in children and adolescents with OCD, we asked whether the presence of a comorbid tic disorder influenced symptom reduction on the Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) after 12 weeks of treatment. RESULTS: Fifteen percent (17 of 112) of patients exhibited a comorbid tic disorder. In patients without tics, results replicated previously published intent-to-treat outcomes: COMB > CBT > SER > PBO. In patients with a comorbid tic disorder, SER did not differ from PBO, while COMB remained superior to CBT and CBT remained superior to PBO. CONCLUSIONS: In contrast to CBT outcomes, which are not differentially impacted, tic disorders appear to adversely impact the outcome of medication management of pediatric OCD. Children and adolescents with obsessive-compulsive disorder and a comorbid tic disorder should begin treatment with cognitive-behavior therapy alone or the combination of cognitive-behavior therapy plus a serotonin reuptake inhibitor. 相似文献
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Jennifer B Freeman Molly L Choate-Summers Phoebe S Moore Abbe M Garcia Jeffrey J Sapyta Henrietta L Leonard Martin E Franklin 《Neuropsychopharmacology》2007,61(3):337-343
Obsessive-compulsive disorder (OCD) is a distressing and functionally impairing disorder that can emerge as early as age 4. Cognitive behavior therapy (CBT) for OCD in youth shows great promise for amelioration of symptoms and associated functional impairment. However, the empirical evidence base for the efficacy of CBT in youth has some significant limitations, particularly as related to treating the very young child with OCD. This report includes a quantitative review of existing child CBT studies to evaluate evidence for the efficacy of CBT for OCD. It identifies gaps in the literature that, when addressed, would enhance the understanding of effective treatment in pediatric OCD. Finally, it presents a proposed research agenda for addressing the unique concerns of the young child with OCD. 相似文献
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Jihad R Salameh Morris E Franklin 《JSLS, Journal of the Society of Laparoendoscopic Surgeons》2004,8(1):61-64
BACKGROUND AND OBJECTIVES: Laparoscopy in patients with poor cardiac function has been the subject of controversy and is considered by many surgeons a relative contraindication. METHODS: We report the case of a patient who presented with acute cholecystitis and choledocholithiasis concurrent with unstable angina. Our experience in laparoscopic management of patients with calculous biliary disease and severe coronary artery disease is examined. RESULTS: The patient was managed by coronary angioplasty and stenting immediately followed by laparoscopic cholecystectomy and common bile duct exploration under close invasive hemodynamic monitoring and low-pressure pneumoperitoneum. Between 1996 and 2001, 39 patients with coronary artery disease and an ASA class of III or IV underwent laparoscopic cholecystectomy. Eight of these patients (20.5%) had common bile duct stones necessitating laparoscopic common bile duct exploration. No conversions were necessary, and no major morbidity or mortalities occurred. CONCLUSIONS: Laparoscopic cholecystectomy and common bile duct exploration can be safely performed in patients with severe ischemic cardiac disease under close hemodynamic monitoring and a low-pressure pneumoperitoneum (10 to 12 mm Hg). 相似文献
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Preliminary experience with new bioactive prosthetic material for repair of hernias in infected fields 总被引:15,自引:5,他引:10
Surgisis (Cook Surgical, Bloomington, Ind., USA) is a new four-ply bioactive, prosthetic mesh for hernia repair derived from
porcine small-intestinal submucosa. It is a naturally occurring extracellular matrix which is easily absorbed, supports early
and abundant new vessel growth, and serves as a template for the constructive remodeling of many tissues. As such, we believe
that Surgisis mesh is ideal for use in contaminated or potentially contaminated fields in which ventral, incisional, or inguinal
hernia repairs are required. From November 2000 through May 2002, 25 patients (11 male, 14 female) underwent placement of
Surgisis mesh for a variety of different hernia repairs. A total of 25 hernia repairs were performed in our patient population.
Fourteen procedures (56%) were performed in a potentially contaminated setting (i.e. with incarcerated/strangulated bowel
within the hernia or coincident with a laparoscopic cholecystectomy/colectomy). Eleven repairs (44%) were performed in a grossly
contaminated field, including one in which an infected polypropylene mesh from a previous inguinal hernia repair was replaced
with Surgisis and one in which necrotic bowel was discovered within the hernial sac. Median follow-up was 15 months with a
range of 1–20 months. Of the 25 total repairs, there was one wound infection complicated by enterocutaneous fistula in a patient
originally operated on for ischemic bowel. The fistula was in a location independent of the Surgisis mesh. There were no mesh-related
complications or recurrent hernias in our early postoperative follow-up period. Surgisis mesh appears to be a promising new
prosthetic material for hernia repair, especially in contaminated or potentially contaminated fields. Obviously, long-term
follow-up is still required.
Electronic Publication 相似文献
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