全文获取类型
收费全文 | 2145篇 |
免费 | 115篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 33篇 |
妇产科学 | 24篇 |
基础医学 | 245篇 |
口腔科学 | 107篇 |
临床医学 | 134篇 |
内科学 | 568篇 |
皮肤病学 | 9篇 |
神经病学 | 265篇 |
特种医学 | 109篇 |
外科学 | 338篇 |
综合类 | 8篇 |
一般理论 | 2篇 |
预防医学 | 98篇 |
眼科学 | 49篇 |
药学 | 138篇 |
中国医学 | 2篇 |
肿瘤学 | 121篇 |
出版年
2024年 | 3篇 |
2023年 | 21篇 |
2022年 | 35篇 |
2021年 | 70篇 |
2020年 | 43篇 |
2019年 | 75篇 |
2018年 | 75篇 |
2017年 | 43篇 |
2016年 | 73篇 |
2015年 | 68篇 |
2014年 | 99篇 |
2013年 | 99篇 |
2012年 | 177篇 |
2011年 | 192篇 |
2010年 | 101篇 |
2009年 | 81篇 |
2008年 | 155篇 |
2007年 | 146篇 |
2006年 | 142篇 |
2005年 | 120篇 |
2004年 | 125篇 |
2003年 | 106篇 |
2002年 | 70篇 |
2001年 | 10篇 |
2000年 | 7篇 |
1999年 | 9篇 |
1998年 | 12篇 |
1997年 | 15篇 |
1996年 | 7篇 |
1995年 | 9篇 |
1994年 | 5篇 |
1993年 | 4篇 |
1992年 | 6篇 |
1991年 | 10篇 |
1990年 | 4篇 |
1989年 | 3篇 |
1988年 | 5篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1984年 | 8篇 |
1982年 | 5篇 |
1981年 | 5篇 |
1980年 | 3篇 |
1977年 | 2篇 |
1976年 | 5篇 |
1974年 | 2篇 |
1965年 | 3篇 |
1961年 | 1篇 |
1936年 | 1篇 |
1934年 | 1篇 |
排序方式: 共有2269条查询结果,搜索用时 703 毫秒
41.
Gagliardi Federica Lauro Augusto Tripodi Domenico Amabile Maria Ida Palumbo Piergaspare Di Matteo Filippo Maria Palazzini Giorgio Forte Flavio Frattaroli Stefano Khouzam Simone Marino Ignazio R. DAndrea Vito Sorrenti Salvatore Pironi Daniele 《Digestive diseases and sciences》2022,67(3):786-798
Digestive Diseases and Sciences - Mesenteric cysts are defined as a heterogeneous group of intra-abdominal cystic lesions of the mesentery or omentum that may be found in any portion of the... 相似文献
42.
Dejan Orlic Bernhard Reimers Goran Stankovic Nicola Corvaja Alaide Chieffo Flavio Airoldi Vassilis Spanos Luca Favero Carlo Di Mario Antonio Colombo 《Catheterization and cardiovascular interventions》2003,60(2):159-166
The purpose of this study was to evaluate the safety and efficacy of the new Fox Hollow atherectomy device (FHT) designed for more efficient and easier plaque removal. The FHT has short rigid section and low-profile cutter mounted on a monorail catheter. The FHT catheter was utilized in 77 patients with 98 lesions. Mean reference vessel diameter was 2.75 +/- 0.51 mm. Successful atherectomy with tissue retrieval was performed in 94 lesions (96%). Following atherectomy, mean diameter stenosis was reduced from 71.1% to 31.9% and further to 10.4% following adjunctive treatment. Angiographic complications were one coronary perforation and one adventitial staining, both successfully treated with prolong balloon inflation and stent implantation. Nine patients (11.7%) had in-hospital non-Q-wave myocardial infarction (MI). One patient died (1.3%) for noncardiac reasons and one had MI (1.3%) at 6-month follow-up. Target lesion revascularization was required in 13 (13.8%) lesions and target vessel revascularization in 15 (20.3%) patients. There was target vessel failure in 17 (23.0%) patients. Plaque debulking with the FHT catheter can be performed safely and effectively in relatively small vessels and complex lesions located in mid-distal artery segments with 6-month clinical outcome similar to prior atherectomy devices. 相似文献
43.
Carlo Di Mario Nuccia Morici Cosmo Godino Omer Goktekin Corrado Tamburino Rossella Barbagallo David Antoniucci Eberhard Grube Flavio Airoldi Giuseppe Biondi Zoccai Antonio Colombo Giuseppe M Sangiorgi 《Catheterization and cardiovascular interventions》2007,69(3):416-424
OBJECTIVES: The aim of the study was the assessment of the clinical, angiographic and procedural characteristics correlated with freedom from adverse events at 1 year in a real life setting of consecutive bifurcation lesions. BACKGROUND: Even if stent implantation has shown to be superior to conventional balloon angioplasty in most coronary lesions, bifurcation treatment with stent implantation both in main and in side branch (SB) still raises controversy. METHODS: We reviewed the results obtained in a prospective multicenter registry of 150 patients with 158 bifurcation lesions involving a SB of sufficient diameter to be treated, if necessary, with a polymer based paclitaxel eluting stent (PES, TAXUS). Two stents were used in 118 lesions (74.7%). Final kissing balloon inflation was performed in 87/118 lesions (73.7%) and in 30/40 lesions (75.0%) of the 2 and 1 stent group respectively. RESULTS: At 1-year clinical follow-up we observed 4 stent thromboses, all involving the SBs of the 2 stents group (2.7%). Unlike previous reports, revascularization involved the main vessel in the majority of patients (21/150, 14.0%). After an exploratory multivariable analysis the only parameter predictive of target lesion revascularization (TLR) (HR 0.52; CI 95% 0.11-0.86; p = 0.02) and target vessel revascularization (TVR) (HR 0.47; CI 95% 0.14-0.90; p = 0.03) was postprocedural main branch minimal lumen diameter (MB-MLD). CONCLUSIONS: In a real life setting of consecutive bifurcation lesions, thrombosis rate, concentrated in the SB and the 2-stents group, and need for target lesion revascularization remain higher than in less complex lesion subgroups treated with PES. No differences in immediate success and TLR were observed between 2 stents and 1 stent groups. The frequently observed suboptimal stent expansion and final MB-MLD predict 1 year revascularization. 相似文献
44.
Treatment of Ulcerative Colitis with Oral 5-Aminosalicylic Acid Including Patients with Adverse Reactions to Sulfasalazine 总被引:3,自引:0,他引:3
Flavio M. Habal M.D. Gordon R. Greenberg M.D. 《The American journal of gastroenterology》1988,83(1):15-19
Sulfasalazine is an effective drug for maintaining remission in ulcerative colitis, but its use may be precluded by side effects. Eighty-five patients with active ulcerative colitis participated in a prospective open trial to examine the tolerance of the active constituent 5-aminosalicylic acid (5-ASA), coated with an acrylic resin, and its efficacy in inducing and subsequently maintaining a remission. Fifty-one of the patients had previously developed adverse reactions to sulfasalazine. After 4 wk of treatment with 3.2 g 5-ASA daily, a remission was achieved in 23 of 36 patients (64%) with mild or moderate disease, but in none of 43 patients with severe disease. Six patients were withdrawn because of side effects to 5-ASA, but only two of these patients had similar reactions on sulfasalazine. Supplementary corticosteroids for 6 wk or less induced a remission in 27 of the patients who had failed on 5-ASA alone. Fifty patients were therefore eligible for the maintenance phase of the trial, and 39 (78%) had a sustained clinical and endoscopic remission upon 1-yr follow-up. 5-ASA appears to be an effective drug for inducing remission in mild or moderate ulcerative colitis and for the maintenance of remission. It thus represents a valuable addition to the management of patients intolerant to sulfasalazine. 相似文献
45.
Mitral regurgitation severity correlates with symptoms and extent of left atrial dysfunction: Effect of mitral valve repair
下载免费PDF全文
![点击此处可从《Journal of clinical ultrasound : JCU》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Matteo Lisi MD Matteo Cameli MD Cristina Di Tommaso MD Valeria Curci MD Rosanna Reccia MD Flavio D'ascenzi MD Marta Focardi PhD Massimo Maccherini MD Mario Chiavarelli MD Gianfranco Lisi MD Per Lindqvist PhD Sergio Mondillo MD Michael Henein MD PhD 《Journal of clinical ultrasound : JCU》2018,46(1):32-40
46.
Cristina Costa Angela Sambataro Sergio Baldi Vittorio Modena Luca Todros Daniela Libertucci Francesco Coni Enrico Fusaro Flavio Revello Angelo Murgia Mario Rizzetto Serafino Recchia Ferruccio Bonino Giorgio Verme Floriano Rosina 《Liver international》1995,15(4):196-201
Abstract: Sub-clinical lung impairment, mostly represented by a reduced diffusion of alveolar gases, is a recognised complication of advanced primary biliary cirrhosis. The aim of the study was to evaluate the prevalence and type of pulmonary involvement in primary biliary cirrhosis and the relationship between lung function abnormalities and selected epidemiological and clinical variables. Sixty-one patients with different stages of primary biliary cirrhosis consecutively seen in our outpatient clinic were evaluated. The advancement of primary biliary cirrhosis was characterised by the histological stage, the presence of signs of portal hypertension and the Mayo Risk Score: a Cox regression model using serum bilirubin and albumin levels, prothrombin time, age and degree of oedema as selected variables. We measured static and dynamic lung volumes, by means of a spirometer, and diffusing capacity for carbon monoxide. Rheumatological disorders were evaluated by an independent rheumatologist. No patient complained of respiratory symptoms. Airway obstruction was present in one patient. In 24 patients (39%) the alveolar diffusion capacity was reduced. We did not find any significant relationship between diffusing capacity and smoking habits, advancement of liver disease and concomitant Sjogren syndrome. Reduced diffusion capacity showed a significant correlation with the presence of complete or incomplete CREST syndrome (p<0.01) and with the presence of circulating anti-centromere antibodies (p<0.05). Alveolar diffusion capacity is frequently impaired in patients with primary biliary cirrhosis, usually in the absence of clinical manifestations. These alterations mostly affect patients with concomitant CREST syndrome. Prospective studies are needed to evaluate if these abnormalities will eventually lead to clinical symptoms and if their progression could be influenced by different therapeutic regimens for primary biliary cirrhosis. 相似文献
47.
Clavio M Nobili F Balleari E Girtler N Ballerini F Vitali P Rosati P Venturino C Varaldo R Gobbi M Ghio R Rodriguez G 《European journal of haematology》2004,72(2):113-120
OBJECTIVE: In this prospective study we evaluate the effects of high-dose recombinant human erythropoietin (rHuEPO) on quality of life (QOL) and brain function in patients with low-risk myelodysplastic syndromes (MDS) (<10% marrow blasts). Preliminary data are reported. METHODS: Eleven consecutive patients were given rHuEPO (40,000 IU two times a week) for 12 wk. Responsive patients continued with 40,000 IU/wk for further 12 wk. Changes in QOL were assessed by the Functional Assessment of Cancer Therapy-Anemia (FACT-An) self-report. Neurophysiological evaluation at the start of the therapy (t0) included duplex scanning of neck vessels, transcranial Doppler sonography (TCD), a complex neuropsychological evaluation, and quantitative electroencephalography (qEEG). Eight patients completed the neurophysiological evaluation after 24 wk (t1). RESULTS: Six patients (55%) achieved an erythroid response after 12 wk, which was maintained after 24 wk of treatment. FACT-An score showed a relevant improvement between t0 and t1 in these patients. At baseline, TCD showed a mean cerebral blood flow (CBF) velocity in the upper normal range. Abnormalities in brain function were observed in five patients. In the eight patients who were re-evaluated at t1, improvement was observed in three responding patients, two of them with abnormal values at t0. A strict correlation between QOL and neurophysiological improvements was not observed. CONCLUSIONS: A high-dose induction phase with rHuEPO followed by maintenance therapy may be an effective therapeutic schedule for low-risk MDS patients. The erythroid response was associated with positive changes in the QOL. Neurophysiological improvements occurred only in a part (50%) of responding patients, mainly those who showed altered results at baseline. 相似文献
48.
49.
Carmen Barba Massimo Cossu Renzo Guerrini Giancarlo Di Gennaro Flavio Villani Luca De Palma Laura Grisotto Alessandro Consales Domenica Battaglia Nelia Zamponi Piergiorgio dOrio Martina Revay Michele Rizzi Sara Casciato Vincenzo Esposito Pier Paolo Quarato Roberta Di Giacomo Giuseppe Didato Chiara Pastori Giusy Carfi Pavia Simona Pellacani Giulia Matta Mattia Pacetti Gianpiero Tamburrini Elisabetta Cesaroni Gabriella Colicchio Giampaolo Vatti Sofia Asioli Massimo Caulo Carlo Efisio Marras Laura Tassi 《Epilepsia》2021,62(1):128-142
50.
Beatrice Orso PsyD Dario Arnaldi MD Nicola Girtler PsyD Andrea Brugnolo PsyD Elisa Doglione PsyD Pietro Mattioli MD Erica Biassoni MD Roberto Fancellu MD Federico Massa MD Matteo Bauckneht MD Silvia Chiola MD Silvia Morbelli MD Flavio Nobili MD Matteo Pardini MD 《Movement disorders》2021,36(10):2293-2302