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排序方式: 共有9317条查询结果,搜索用时 46 毫秒
991.
Martini F Poccia F Goletti D Carrara S Vincenti D D'Offizi G Agrati C Ippolito G Colizzi V Pucillo LP Montesano C 《The Journal of infectious diseases》2002,186(6):847-850
T cells expressing Vgamma9Vdelta2 display lytic and proliferative responses against human immunodeficiency virus (HIV)-infected cells and release antiviral soluble factors. Chronic HIV-positive patients have deep changes in the composition and function of the circulating gammadelta T cell pool that are restored by highly active antiretroviral therapy (HAART). gammadelta T cells were analyzed during the rapid plasma HIV RNA rebound in HIV-infected patients undergoing structured treatment interruption (STI). A loss in circulating Vgamma9Vdelta2 T cells was observed, indicating that acute HIV replication may influence Vgamma9Vdelta2 homeostasis. These cells were lost among CD45RA(-)CD27(-) Vgamma9Vdelta2 T cell effectors, and a significant unresponsiveness, measured as antigen-driven interferon-gamma production, was observed during STI. After HAART resumption and consequent inhibition of HIV replication, Vgamma9Vdelta2 T cell reactivity was restored both quantitatively and functionally. These observations indicate that Vgamma9Vdelta2 T cells are activated early after active HIV replication but are rapidly lost when viremia is not controlled. 相似文献
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993.
Javier Crespo Pablo Lázaro de Mercado Antonio Javier Blasco Bravo Antonio Aguilera Guirao Javier García-Samaniego Rey José María Eiros Bouza José Luis Calleja Panero Federico García 《Enfermedades infecciosas y microbiología clínica》2019,37(4):231-238
Background
Reflex testing of antibodies and viral load in the same sample for diagnosing hepatitis C virus infection speeds up access to treatment. However, how hepatitis C is diagnosed in Spanish hospitals is unknown.Objective
To describe the available resources and procedures for the diagnosis of hepatitis C virus infection in Spain.Methods
Survey sent to public and private Spanish hospitals with teaching accreditation with at least 200 beds.Results
Of the 160 hospitals that met the inclusion criteria, 90 centres (response rate 56.3%) completed the survey. Two hospitals (2.2%) have no diagnostic resources, 15 (16.7%) can only test for anti-hepatitis C virus(Ab), 9 (10.0%) for Ab and viral load, 47 (52.2%) for Ab, viral load and genotype, 2 (2.2%) for Ab, viral load and core antigen, and 15 (16.7%) can perform Ab, core antigen, viral load and genotype tests. When an Ab test is positive, 28 (31.1%) hospitals perform reflex testing. When an active infection is diagnosed, some communication strategy is used in 62 (68.9%) hospitals. Approximately 44.2% of the respondents believe that all determinations needed to reach a definitive diagnosis should be done on a single blood sample.Conclusion
Although 81% of Spanish hospitals have the resources to perform reflex hepatitis C virus infection testing, it is only done in 31%, and less than a half of respondents believe that the definitive diagnosis should be performed on a single sample. 相似文献994.
Guillermo Anselmi Jos A. Surez Ivn Machado Federico Moleiro Pablo Blanco 《Heart (British Cardiac Society)》1970,32(4):575-578
A report is made of a rare case of Wilms' tumour which simulated clinically a syndrome of `right heart failure', as found in some cases of Ebstein's disease. The clinical, radiological, and electrocardiographic study led to the suspicion of this type of malformation. The cine-angiographic study revealed two important facts: the impossibility of approaching the inferior vena cava with opaque material injected into the azygos vein and a filling defect of the right atrium. The post-mortem study revealed the presence of a Wilms' tumour of the right kidney which extended into the inferior vena cava and into the right atrium without producing metastases. This seems to be the first case of this peculiar course of a Wilm's tumour which has grown into the right atrium, resulting in this bizarre clinical picture. 相似文献
995.
Echocardiographic and Biohumoral Characteristics in Patients With AL and TTR Amyloidosis at Diagnosis 下载免费PDF全文
Francesco Cappelli MD Samuele Baldasseroni MD Franco Bergesio MD Stefano Perlini MD Francesco Salinaro MD Luigi Padeletti MD Paola Attanà MD Alessandro Paoletti Perini MD Alberto Moggi Pignone MD Elisa Grifoni MD Alessia Fabbri MD Niccolò Marchionni MD Gian Franco Gensini MD Federico Perfetto MD 《Clinical cardiology》2015,38(2):69-75
996.
997.
Davide Rossi Alessio Bruscaggin Piera La Cava Sara Galimberti Elena Ciabatti Stefano Luminari Luigi Rigacci Alessandra Tucci Alessandro Pulsoni Giovanni Bertoldero Daniele Vallisa Chiara Rusconi Michele Spina Luca Arcaini Francesco Angrilli Caterina Stelitano Francesco Merli Gianluca Gaidano Massimo Federico Giuseppe A. Palumbo 《Haematologica》2015,100(4):517-524
Though most follicular lymphoma biomarkers rely on tumor features, the host genetic background may also be relevant for outcome. Here we aimed at verifying the contribution of candidate polymorphisms of FCγ receptor, DNA repair and detoxification genes to prognostic stratification of follicular lymphoma treated with immunochemotherapy. The study was based on 428 patients enrolled in the FOLL05 prospective trial that compared three standard-of-care regimens (rituximab-cyclophosphamide-vincristine-prednisone versus rituximab-cyclophosphamide-doxorubicin-vincristine-prednisone versus rituximab-fludarabine-mitoxantrone) for the first line therapy of advanced follicular lymphoma. Polymorphisms were genotyped on peripheral blood DNA samples. The primary endpoint was time to treatment failure. Polymorphisms of FCGR2A and FCGR3A, which have been suggested to influence the activity of rituximab as a single agent, did not affect time to treatment failure in the pooled analysis of the three FOLL05 treatment arms that combined rituximab with chemotherapy (P=0.742, P=0.252, respectively). These results were consistent even when the analysis was conducted by intention to treat, indicating that different chemotherapy regimens and loads did not interact differentially with the FCGR2A and FCGR3A genotypes. The genotype of MLH1, which regulates the genotoxic effect of doxorubicin, significantly affected time to treatment failure in patients in the rituximab-cyclophosphamide-doxorubicin-vincristine-prednisone arm (P=0.001; q<0.1), but not in arms in which patients did not receive doxorubicin (i.e., the rituximab-cyclophosphamide-vincristine-prednisone and rituximab-fludarabine-mitoxantrone arms). The impact of MLH1 on time to treatment failure was independent after adjusting for the Follicular Lymphoma International Prognostic Index and other potential confounding variables by multivariate analysis. These data indicate that MLH1 genotype is a predictor of failure to benefit from rituximab-cyclophosphamide-doxorubicin-vincristine-prednisone treatment in advanced follicular lymphoma and confirm that FCGR2A and FCGR3A polymorphisms have no impact when follicular lymphoma is treated with rituximab plus chemotherapy (clinicaltrials.gov identifier: ). NCT00774826相似文献
998.
999.
1000.
Paolina Crocco Roberto Barale Giuseppina Rose Cosmeri Rizzato Aurelia Santoro Francesco De Rango Maura Carrai Paola Fogar Daniela Monti Fiammetta Biondi Laura Bucci Rita Ostan Federica Tallaro Alberto Montesanto Carlo-Federico Zambon Claudio Franceschi Federico Canzian Giuseppe Passarino Daniele Campa 《Biogerontology》2015,16(3):353-364