全文获取类型
收费全文 | 2153篇 |
免费 | 148篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 39篇 |
儿科学 | 113篇 |
妇产科学 | 82篇 |
基础医学 | 211篇 |
口腔科学 | 60篇 |
临床医学 | 170篇 |
内科学 | 522篇 |
皮肤病学 | 48篇 |
神经病学 | 102篇 |
特种医学 | 42篇 |
外国民族医学 | 1篇 |
外科学 | 435篇 |
综合类 | 83篇 |
一般理论 | 1篇 |
预防医学 | 113篇 |
眼科学 | 46篇 |
药学 | 133篇 |
中国医学 | 3篇 |
肿瘤学 | 113篇 |
出版年
2023年 | 25篇 |
2022年 | 75篇 |
2021年 | 140篇 |
2020年 | 75篇 |
2019年 | 96篇 |
2018年 | 107篇 |
2017年 | 69篇 |
2016年 | 66篇 |
2015年 | 60篇 |
2014年 | 68篇 |
2013年 | 97篇 |
2012年 | 128篇 |
2011年 | 173篇 |
2010年 | 87篇 |
2009年 | 64篇 |
2008年 | 87篇 |
2007年 | 100篇 |
2006年 | 91篇 |
2005年 | 84篇 |
2004年 | 78篇 |
2003年 | 72篇 |
2002年 | 69篇 |
2001年 | 31篇 |
2000年 | 20篇 |
1999年 | 35篇 |
1998年 | 15篇 |
1997年 | 10篇 |
1996年 | 13篇 |
1995年 | 12篇 |
1994年 | 9篇 |
1993年 | 9篇 |
1992年 | 20篇 |
1991年 | 20篇 |
1990年 | 19篇 |
1989年 | 13篇 |
1988年 | 11篇 |
1987年 | 15篇 |
1986年 | 17篇 |
1985年 | 15篇 |
1984年 | 8篇 |
1983年 | 7篇 |
1980年 | 9篇 |
1979年 | 11篇 |
1977年 | 9篇 |
1976年 | 8篇 |
1975年 | 9篇 |
1974年 | 6篇 |
1973年 | 7篇 |
1970年 | 5篇 |
1969年 | 5篇 |
排序方式: 共有2317条查询结果,搜索用时 15 毫秒
51.
Productive human immunodeficiency virus infection levels correlate with AIDS-related manifestations in the patient. 总被引:3,自引:1,他引:3
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
D Mathez D Paul C de Blilovsky Y Sultan J Deleuze I Gorin W Saurin R Decker J Leibowitch 《Proceedings of the National Academy of Sciences of the United States of America》1990,87(19):7438-7442
Mononuclear cells were obtained from 71 human immunodeficiency virus type 1 (HIV-1) seropositive subjects presenting and first visit either as asymptomatic or with minor symptoms and with CD4 lymphocytes greater than 550 per mm3 (group A, 35 patients) or as patients with AIDS, AIDS-related illnesses, or CD4 lymphocytes less than 400 per mm3 (group B, 36 patients). After 1-5 years of follow-up, 13 patients of group A had essentially retained their initial status (asymptomatics); the 22 others had suffered clinical or immunological deterioration (progressors). Frozen cells were thawed and submitted to lethal gamma-irradiation in vitro (4500 rads; 1 rad = 0.01 Gy) before they were cultured with normal phytohemagglutinin-stimulated lymphocytes to determine radiation-resistant HIV expression ex vivo (R-HEV). HIV antigenemia correlated with R-HEV values in 142 samples (r = 0.92, P less than 0.001) but was a less sensitive predictor of disease than R-HEV. R-HEV was detected in all specimens from patients with major AIDS-related illnesses or HIV-associated CD4 lymphopenia. In 77% of the progressors from group A, R-HEV detection preceded the onset of AIDS-associated disease or CD4 lymphopenia by 1 year (average). Conversely, R-HEV was low or was not detected in 36 sequential specimens from the 13 patients who remained asymptomatic over the following 2-5 years. Thus, persistently low HIV expression in vivo predicted a nondiseased state, whereas higher HIV expression levels seemed necessary for disease to occur. These data indicate that R-HEV is related to productive HIV infection in vivo, the latter acting as a determinant of AIDS-related illnesses. In view of this, measurement of HIV expression levels in the patient should be useful in antiviral efficacy trials. 相似文献
52.
53.
Adem Aydin Yavuz Selvi Lutfullah Besiroglu Murat Boysan Abdullah Atli Osman Ozdemir Sultan Kilic Ragıp Balaharoglu 《Journal of affective disorders》2013
It has been commonly recognized that circadian rhythm and sleep/wake cycle are causally involved in bipolar disorder. There has been a paucity of systematic research considering the relations between sleep and mood states in bipolar disorder. The current study examines the possible influences of sleep deprivation on mood states and endocrine functions among first-degree relatives of patients with bipolar disorder and healthy controls. Blood samples were taken at two time points in the consecutive mornings at predeprivation and postdeprivation periods. Participants simultaneously completed the Profiles of Mood States at two time points after giving blood samples. Plasma T3 and TSH levels increased after total sleep deprivation in both groups. Sleep deprivation induced TSH levels were reversely associated with depression–dejection among healthy controls. A paradoxical effect was detected for only the first-degree relatives of the patients that changes in plasma cortisol levels negatively linked to depression–dejection and anger–hostility scores after total sleep deprivation. Plasma DHEA levels became correlated with vigor-activity scores after sleep deprivation among first-degree relatives of bipolar patients. On the contrary, significant associations of depression–dejection, anger–hostility, and confusion–bewilderment with the baseline plasma DHEA levels became statistically trivial in the postdeprivation period. Findings suggested that first-degree relatives of patients with bipolar disorder had completely distinct characteristics with respect to sleep deprivation induced responses in terms of associations between endocrine functions and mood states as compared to individuals whose relatives had no psychiatric problems. Considering the relationships between endocrine functions and mood states among relatives of the patients, it appears like sleep deprivation changes the receptor sensitivity which probably plays a pivotal role on mood outcomes among the first-degree relatives of patients with bipolar disorder. 相似文献
54.
55.
56.
57.
Muslum Kul Fatih Unal Hasan Kandemir Bahram Sarkarati Kamer Kilinc Sultan Basmac? Kandemir 《Psychiatry investigation》2015,12(3):361-366
Objective
Oxidative metabolism is impaired in several medical conditions including psychiatric disorders, and this imbalance may be involved in the etiology of these diseases. The present study evaluated oxidative balance in pediatric and adolescent patients with attention deficit hyperactivity disorder (ADHD).Methods
The study included 48 children and adolescents (34 male, 14 female) with ADHD who had no neurological, systemic, or comorbid psychiatric disorders, with the exception of oppositional defiant disorder (ODD), and 24 sex- and age-matched healthy controls (17 male and seven female).Results
TAS was significantly lower, and TOS and OSI were significantly higher in patients with ADHD than in healthy controls. Total antioxidant levels were lower in patients with comorbid ODD than in those with no comorbidity. No difference was found in TOS or OSI among the ADHD subtypes; however, TAS was higher in the attention-deficient subtype.Conclusion
Our findings demonstrated that oxidative balance is impaired and oxidative stress is increased in children and adolescents with ADHD. This results are consistent with those of previous studies. 相似文献58.
Four unrelated patients with a severe form of von Willebrand disease showed no detectable factor VIII-related antigen (VIIIR:AG) in either their plasma or their platelets. They received cryoprecipitate infusions, three patients in a single injection each and one every day for 9 days before and after surgery. Platelet VIIIR:Ag was studied at different times during and after transfusion using electroimmunoassay of platelet extracts and electron microscopy of the platelets incubated with anti-VIIIR:Ag antibodies coupled to peroxidase. No VIIIR-Ag was detected in or around the patients' platelets, although this antigen was detected in the circulating blood. These results that there was no VIIIR:Ag uptake from the plasma by the platelets and that platelet VIIIR:Ag came from megakaryocytes. 相似文献
59.
Proposals for the Classification of the Acute Leukaemias French-American-British (FAB) Co-operative Group 总被引:96,自引:0,他引:96
J. M. Bennett D. Catovsky †Marie-Theregse Daniel ‡G. Flandrin ‡D. A. G. Galton †H. R. Gralnick §C. Sultan ¶ 《British journal of haematology》1976,33(4):451-458
A uniform system of classification and nomenclature of the acute leukaemias, at present lacking, should permit more accurate recording of the distribution of cases entered into clinical trials, and could provide a reference standard when newly developed cell-surface markers believed to characterize specific cell types are applied to cases of acute leukaemia. Proposals based on conventional morphological and cytochemical methods are offered following the study of peripheral blood and bone-marrow films from some 200 cases of acute leukaemia by a group of seven French, American and British haematologists. The slides were examined first independently, and then by the group working together. Two groups of acute leukaemia, 'lymphoblastic' and myeloid are further subdivided into three and six groups. Dysmyelopoietic syndromes that may be confused with acute myeloid leukaemia are also considered. Photomicrographs of each of the named conditions are presented. 相似文献
60.
Ahmed Mousa Altaf A. Kondkar Saleh A. Al-Obeidan Taif A. Azad Tahira Sultan Essam Osman Khaled K. Abu-Amero 《Saudi medical journal》2015,36(6):671-677