补肺化积汤治疗晚期非小细胞肺癌

目的 观察中药支持和补肺化积汤治疗晚期非小细胞肺癌的效果.方法 将60例非小细胞肺癌患者随机分为治疗组与对照组,各30例.对照组采用艾迪注射液做支持疗法,治疗组在此基础上配合补肺化积汤治疗.治疗3个疗程后观察2组临床疗效.结果 治疗组瘤体的缓解程度、Karnofsky评分等均优于对照组.结论 补肺化积汤对正虚毒结型非小细胞肺癌具有良好的治疗效果.     

Strategies for myelin regeneration: lessons learned from development

Myelin regeneration is indispensably important for patients suffering from several central nervous system （CNS） disorders such as multiple sclerosis （MS） and spinal cord injury （SCI）, because it is not only essential for restoring neurophysiology, but also protects denuded axons for secondary degeneration. Understanding the cellular and molecular mechanisms underlying remyelination is critical for the development of remyelination-specific therapeutic approaches. As remyelination shares certain common mechanisms with developmental myelination, knowledge from study of developmental myelination contributes greatly to emerging myelin regeneration therapies, best evidenced as the recently developed human anti-Nogo receptor interacting protein-1 （LINGO-1） monoclonal antibodies to treat MS patients in clinical trials.     

Role of surgery in the treatment of patients with high-risk neuroblastoma who have a poor response to induction chemotherapy

Background

In instances of high-risk neuroblastoma that do not show a clinical response to induction therapy, whether it is worth performing surgical resection or not and whether gross total resection (GTR) is more important than subtotal resection (STR) remain controversial.

Methods

We retrospectively analyzed the data of patients with stage 4 neuroblastoma aged 18 months or older at diagnosis. Primary tumor volumes were measured both at diagnosis and at the first tumor response evaluation (after 6 cycles of induction chemotherapy). If the tumor volume at the first response evaluation was > 50% of the initial tumor volume, the patient was categorized as a poor responder. Otherwise, the patient was categorized as a good responder. Only poor responders were included. Patients were evaluated for event-free survival (EFS), overall survival (OS), and complications of surgery based on extent of surgical intervention.

Results

Sixty-five patients were included in this study. The 41 patients who underwent surgical intervention had a higher 3-year OS than the 24 patients who had a biopsy only (55.4% ± 8.1% vs. 31.3% ± 10.2%, P = 0.02). However, there was limited improvement in 3-year EFS following surgical intervention. Three-year EFS rates of BX group (biopsy only) and OP group (surgical resection) were 24.2% ± 9.3% and 37.7% ± 7.9%, respectively (P = 0.063). The extent of resection had no impact on 3-year OS (P = 0.631) and 3-year EFS (P = 0.796). Patients in the GTR group trended to have more severe surgical complications than patients in the STR group (P = 0.105).

Conclusions

For high-risk neuroblastomas that do not show a clinical response to induction therapy, surgical resection is important in predicting outcome, but the extent of resection is not.     

VEGF、TGF-β1、NF-κBp65在颅内海绵状血管瘤的表达及意义

目的探讨脑海绵状血管瘤（CCH）组织血管内皮细胞生长因子（VEGF）、转化生长因子β1（TGF-β1）、核转录因子κBp65（NF-κBp65）的表达及意义。方法收集我院2009年6月到2011年12月CCH标本27例,脑动静脉畸形（AVM）标本9例和正常脑组织标本（颅脑损伤或癫痫术中切取的脑组织）6例,用免疫组化方法检测VEGF、TGF-β1、NF-κBp65的表达。结果CCH组织VEGF、NF-κBp65阳性表达率（分别是96．3％和70．4％）显著高于正常脑组织（分别为33．3％和0;P〈0．05）,而与脑AVM组织（分别是77．8％和44．4％）无显著差异（P〉0．05）;脑AVM组织TGF-β1表达阳性率（100％）显著高于CCH组织（33.3％,P〈0．05）和正常脑组织（16．7％,P〈0．05）。结论VEGF、TGF-β1、NF-κBp65在不同组织表达水平不一样,提示VEGF、NF-κBp65与CCH形成有关,而TGF-β1可能在其形成过程中意义不大。     

护士长工作疲溃感和婚姻质量相关性的研究进展

简述了工作疲渍感、婚姻质量的概念及其关系，并对护士长工作疲渍感和婚姻质量的研究现状进行综述。     

高密度聚乙烯装置旋液分离器堵塞原因及对策分析

30万吨/年高密度聚乙烯装置旋液分离器D3001A/B在生产的过程中容易堵塞。从旋液分离器顶部密度增加、反应器的内部固体含量(Solids-in)增加及淤浆加热器的热负荷增加等现象可以判断D3001A/B堵塞。根据不同反应模式和生产牌号,从反应器正常运行的参数和堵塞时的参数进行分析,并提出有效的优化措施,如降低顶部回流量,减小底部固体浓度和保证旋液分离器内壁光滑度等。